Mechanisms of enzymatic catalysis: a summary Stabilization of the…

Mechanisms of enzymatic catalysis: a summary Stabilization of the enzyme-bound transition state EX‡ 1. General acid/base catalysis 2. Intramolecular catalysis (Proximity & orientation of substrates) 3. Electrostatic catalysis 4. Metal ion catalysis 5. Covalent catalysis Destabilization of the enzyme-substrate complex, ES 1. Entropy loss on binding of substrate 2. Desolvation of substrate 3. Electrostatic destabilization