Case Analysis And Problems With Dementia Nursing Essay

Dementia is a progressive and irreversible decline in mental function1. Lewy Body Dementia (DLB) is a form of degenerative dementia characterised by the presence of “Lewy Bodies” which are clumps of alpha-synuclein and ubiquitin protein in neurons2. These are only detectable in post-mortem brain biopsies2.

The manifestations of dementia present themselves clinically as progressive cognitive decline which impairs day-to-day social and motor functioning. This central feature of DLB is essential for the initial diagnosis of the disorder and the initial evaluation of a patient with dementia must establish the presence of cognitive impairment and provide a measure of its severity. Three core features which are significant in the diagnosis of DLB and distinguishing it from these other disorders are2:

1.   Fluctuations in both mental cognition and relative levels of attentiveness. The severity and duration of these episodes vary among patients, however, generally, severity increases with time.

2.   Visual Hallucinations – characteristically detailed and well-formed; significant in differentiating DLB from Alzheimer’s disease as they are relatively rare in the latter disorder.

3.   Spontaneous features of Parkinsonism, such as tremors.

At least two of these core features must be present to conclude that there is DLB3. Suggestive features of the disorder include rapid eye movement (REM) sleep behaviour disorder, repeated falls and transient loss in consciousness. In the absence of a core clinical feature the presence of one or more of these suggestive features may help in the diagnosis of DLB. The differential diagnosis for DLB is mainly Alzheimer’s disease, Parkinson’s disease or other dementia syndromes. However, in Catherine’s case the presence of a number of core and suggestive features strongly indicate DLB.

In relation to Catherine, there are many indicators present which qualify her for diagnosis with the disease. Not only does she exhibit some of the core features mentioned previously but it is also evident that she is suffering from some of the more suggestive, but equally as debilitating, aspects of the disease. It is evident on examination that Catherine is experiencing fluctuations in cognition as her verbal responses are often difficult to comprehend and are unreliable. These memory lapses, along with aggressive responses, are known symptoms of dementia2. She has had some vivid visual hallucinations previously which may be a mitigating factor in her continuous falls, another suggestive feature of the disorder2.

Catherine’s husband faces many challenges as her primary caregiver. Caregiver burden is defined as the high levels of stress and anxiety associated with the provision of care to another person suffering from some kind of illness4. Catherine’s husband is likely to suffer from caregiver burden as he is the sole provider of care and his closest source of relief is his daughter who lives some distance away. He faces challenges in communication and in managing Catherine’s behaviour and struggles with his own physical fitness while also trying to care for his wife. He is likely to suffer emotionally as result of the demands placed upon him as a result of Catherine’s unwillingness to avail of respite care services.

Catherine presents many challenges to the healthcare system in that she is aggressive towards members of staff with whom she is unfamiliar. This impedes upon the quality of her care as nursing staff appreciate her condition but are unable to manage it on an acute ward. The problems with her memory make interactions difficult as she does not remember her surgical treatment and becomes aggressive and agitated at times. It is likely that as the disease progresses these factors will become more serious and incapacitating, leaving her husband with no choice but to admit her to a long-term care facility.

Societal Context

It is difficult to quantify the prevalence of Dementia in Ireland and in various countries due to variances in how we define and ration dementia and also due to methodological variances in conducting studies5. However there remain some factors such as age and gender which show consistencies across studies. It has been found that Alzheimer’s disease is more common in women, and that prevalence of dementia can double with every 5 years of increase in age6.

The Alzheimer Society of Ireland (ASI) estimates that there are currently more than 44,000 people suffering from some form of dementia in Ireland7. It is shown that the prevalence is higher in females than males with 20,000 females and 14,000 males found to be suffering in 2002 and the incidence is expected to increase dramatically in the coming years in correspondence with the aging population in Ireland. By the year 2036 the ASI estimates that there will be over 100,000 people with dementia8.

Studies have shown there are a number of risk factors associated with dementia. Along with age and gender, genetics and BMI have also been linked closely with dementia. One study found that normal-weight women had a greater risk of developing dementia than women with a higher BMI than them9. It has also been found that those with higher BMI have a decreased risk of cognitive decline10. Cholesterol levels have also been linked to the cause of dementia in that high levels of high density lipoprotein have been associated with a decreased risk of Alzheimer’s disease11.

There are a number of known support groups in this country for relatives of patients with dementia7. For example, The Alzheimer Society of Ireland provides a range of services to people with Alzheimer’s disease and other forms of dementia. The Carer and Family Support Groups operate throughout Ireland, usually meeting on a monthly basis7. This support network offers a vital opportunity for carers and family members to share experiences, information and practical advice in a supportive environment and would be of significant benefit in Catherine’s case to provide her husband with an outlet from the constant pressures associated with her disease.

The Irish Government does offer some financial support to people suffering from dementia but it appears not to be enough. There are a number of schemes which provide home care to patients, however a new report illustrates that Ireland spends only half the OECD (Organization of Economic Cooperation and Development) average on dementia services12 despite the fact we rival any other European Country in relation to the growth of dementia. According to the report for every 18,500 euro cut, four people with dementia will lose any service provided by the government12. This would be detrimental in Catherine’s case as she may eventually rely heavily on the government for support.

Healthcare Quality and Patient Safety

The treatment of Dementia is focused towards specific disease manifestations as there are no definitive treatments available. To effectively treat Dementia, patients and families should be involved as soon as the diagnosis is made. The availability of information, good health services, and support should be provided to help patients and their families to cope with dementia. The behavioural and psychological symptoms of dementia have been a difficult management area for neurologists and psychiatrists alike. The key to proper management is the correct identification of each symptom and the underlying precipitating cause. The proper management is not only rewarding in terms of responsiveness in an otherwise incurable and progressive disease, but also improves the quality of life of the patients and the caregivers.

The management of dementia begins with a thorough assessment to search for underlying causes of behavioural changes. Non-pharmacological approaches should be used prior to medication use. These interventions include music, light, changes in level of stimulation and specific behavioural techniques. The type of dementia, individual symptom constellation and the tolerability of the patient will help to determine what medication should be used13.

Cholinesterase inhibitors treatment for people with DLB is commonly used in clinical practice, especially for patients that exhibit neuropsychiatric symptoms. The use of antipsychotics for agitation and aggression has shown consistent efficacy and it is the most studied pharmacological intervention14. Pharmacotherapy must be monitored closely for both effectiveness and side effects, with consideration of medication withdrawal when appropriate. Studies show that anti-dementia medicine neither cure, arrest nor delay the onset of the disease, but are helpful in symptom relief14. There is an urgent need to develop more efficacious medications for the treatment of dementia15 as in the long-term we know that a diagnosis of dementia is a sentinel event that signifies progressive loss of independence and increasing demands on caregivers.

In this case, the biggest barrier to Catherine receiving adequate healthcare is herself and the uncooperative and aggressive nature of her condition. Her husband and family cannot fully support her needs therefore she needs to be admitted to a long-term care facility. Her wishes to continue living in her own home may prevent her from getting the care she needs. Also, the fact that her husband must make the decision could be considered a barrier as he is unwilling to put her into long-term care, where the stability may help her.

Individualised rehabilitation approaches targeting relevant and personally-meaningful aspects of everyday functioning have demonstrated significant benefits in single-case and small-group intervention studies16. Cognitive rehabilitation is a relatively new approach to improving well-being for people with dementia and their families, but at present only preliminary evidence regarding efficacy is available16. However, this preliminary evidence suggests that cognitive rehabilitation does have the potential to bring about changes in behaviour, enhance well-being and maintain involvement in daily life. Psychosocial interventions of this kind can be provided alongside pharmacological treatment, and it is possible that these two approaches can complement one another to optimize benefits for the person with dementia17. There are a great many questions still to be answered, but the existing evidence provides a valuable basis for further development of this approach.

Ethical Considerations

There are a number of ethical issues to address in Catherine’s case. As DLB progresses, it gradually renders people incapable of tending to their own needs, thus their decision-making capacity is compromised and caretakers must step in and make decisions for them. Catherine suffers from dementia and requires constant care. In preventing Catherine from independently getting in and out of bed, several ethical issues are involved. Her caretakers can only effectively tend to her and ensure her safety by compromising her right of autonomy for the sake of beneficence18 i.e. doing this for her own well-being in order to provide her with adequate care. Also non-maleficence18 is a factor in this situation i.e. they must ensure she does not get harmed while moving about unsupervised

In Ireland, under the Mental Health Act of 2001, certain conditions must be must be met before someone is involuntarily admitted to a long-term care facility19. Fundamentally

The patient must be eligible to be involuntarily admitted

The “Person” sending the patient must send in application for the patient

That “Person” must fit certain requirements.

After application, a registered medical practitioner must do an examination on the patient and if he/she is satisfied, he/she writes a recommendation for the involuntary admittance of the patient in an approved centre.

Catherine definitely fits the requirements of the patient to be involuntarily admitted as she is actually suffering from a mental disorder20 and her caretakers may be considered “unfit” to take care of her. While her husband wants to respect her wishes he is physically unable to provide the level of care that she needs, even with his daughter’s weekly assistance. It is obvious that she requires constant monitoring as evident by her repeated falls. Therefore, after a mental health assessment it is likely that she be recommended to live in such a facility with more appropriate care21.

Healthcare providers are only able to advise patients and their family members on the best course of treatment and management plan available, suggesting alternatives are still within their boundaries. However, the final choice always resides with the patient and his/her family members22. Disputes which may arise become a tough issue for health care professionals to resolve, as all circumstances need to be taken into consideration before a decision can be reached23.

Word Count: 1989

Search Strategy

As part of our search strategy we used resources from the library and those online.  We found books and journals in the library useful for sourcing background information about Lewy Body Dementia. Online we used medical search database, “Medline” and “PubMed.” We had to tailor our search criteria to suit the particular section of the report we were writing.  To further refine our search findings we used the advanced search and used the “limits” option. If our search yielded too few findings, we learnt to change our keywords and to broaden our search area. For example when “Dementia” is searched PubMed reveals 119494 options, however if “dementia AND Ireland” is searched 404 results are revealed. To further refine this search we used “Limits” whereby we limited the findings to trials that had links to the free article online, were in English and were conducted on humans. This searched revealed 60 findings.

It is also useful to use sources that have been referenced by other authors and we found that once you found one or two good trials, they usually had referenced some other sources that matched your search criteria. This cut down on the searching through irrelevant articles and proved better use of our time.  All in all we found the internet very useful for sourcing our references and in particular we found PubMed and Medline user friendly once we understood how to use them properly.

Overview & Impact of UNICEF for Vulnerable Children




Executive summary

Everyone all have the right to the lead the lives they choose free from abuse as a result of one vulnerable effects, danger to health and life or due to any other circumstances. Unfortunately there are times and scenarios where people are faced with neglects, treats to life, exploitation harm and abuse especially

children

. It is very important to ensure that people who are vulnerable receives all the basic support and assistance to keep them safe and protected all the time.

United Nations International Children Emergency Funds (UNICEF) is part of the world’s organisations providing help and support to the vulnerable from all over the world after working in over one hundred and ninety (190 different countries.

However, UNICEF is readily available to respond to emergencies that strike any person or countries delivering lifesaving help to children within 48 hours (UNICEF, 2014). This organisation helps in five major areas of concern which includes, violence exploitation and abuse, Disease, Hunger and malnutrition, war and conflict and Disasters.

Furthermore, it can be seen that all this areas are the world’s most threatening scenarios which makes UNICEF the world most recognised organisation that provides support. It is however the only organisation that is specifically named under the United Nation (UN) convection on the rights of a child as a source of expert assistant and adviser.


Table of Contents (Jump to)


Executive summary


INTRODUCTION


WHY SUPPORT THE WORK OF THIS ORGANISATION




INTRODUCTION

A vulnerable person is referred to as anyone who is or may be, in any case unable to take care of his or herself financially, health wise or issues concerning significant harm or exploitation. This maybe as a result of mental illness, physical disabilities, sensory impairment, war, old age or as the case maybe.

However, due to all these above vulnerability, such an individual or group of people are liable to receive care services in their houses, community or even country as a whole. This health care practices or support are usually carried out by registered organisation whose sole aim is to protect people in need and the vulnerable.


UNICEF

was originally establish by the united nation in December 1946 by the united nation to provide food, clothing to the European children after the

World War 2

, when the countries were facing disease and famine.


UNICEF

is part of the world’s leading organisation that provides support to vulnerable people. This organisation works for children and child rights and other related issues, having tentacles in over more than one hundred and ninety (190) countries, including families, local communities, business partners and Government to help each and every child reach their full potential.

A

Fig 1 (UNICEF, 2014)




WHY SUPPORT THE WORK OF THIS ORGANISATION

UNICEF is known for their positive impact in the nation’s welfare considering the vulnerable and the less privileged people. Right now children and lots of people face violence, diseases, and hunger, war and natural disaster. This issue is getting alarming and due course to reduce it are really being concentrated on by organisation like SCOPE, OXFAM, NSPCC especially UNICEF.

UNICEF helps ensure that most of the world’s children are in good condition, fed, vaccinated educated, protected and taken care of than any other leading organisation. UNICEF is based and established in over 190 countries in the world, influencing the laws, policies and customs of such countries in other to help benefit the vulnerable people or people in need.

United Nation International Children Emergency Fund (UNICEF) is a charitable organisation that believes that every person’s lives matters throughout their life time right up until they die, and that no one deserves to be in an avoidable pain, sufferings or any kind of emotional distress.

This organisation was established in order to conquer the barrier of poverty, violence, diseases and discrimination placed in every child’s path. Not supporting this kind of organisation after considering all the positive things and actions they carry out is like ignoring JESUS’s coming.


ISSUES BEING ADDRESSED BY THE ORGANISATION

UNICEF is the driving force that helps build a world where the rights of every child are realised. It is believed that nurturing and caring for children and the people in needs are the cornerstones of human progress. UNICEF focuses on five big and major dangers children faces in the world today. Which are;

  • Violence, exploitation and abuse
  • Disease
  • Hunger and malnutrition
  • War and conflict
  • Disaster


Violence, exploitation and abuse:

According to the UNICEF UK report, “every five minutes a child dies as a result of violence, while more children live in fear and panic of physical, emotional and sexual abuse and however this has a long term effect on any children that is being exposed to such a bad experience. In some cases children are being beaten up, raped or even to the extent of murder in some cases as a result of violence. (UNICEF, 2010)

Children that are victim of violence are likely to develop “soldiers exposed to combat” which means they later be lured into being a drug addict, drunk or mentally derailed due to series of horrible experience they went through.

Post-traumatic stress disorder is one of the long lasting symptoms that tends to happen to children that have been abuse or victim of violence. Child trafficking is also one of the abuse which any children could face.

As a charitable organisation, UNICEF helps protect these children and their families by setting up services and working as part of a team with the government to ensure national child protection system are effective. And also informative declarations are made to the communities to change their approach towards abuse and violence and know that it is not acceptable.


Disease:

Lots of children are in danger of deadly but preventable diseases e.g tuberculosis, tetanus, measles, polio, diphtheria and whooping cough. Children dies from these diseases as a result of lack of health care facilities in the country. And all these diseases can easily be prevented by immunisation.

It is noted that children faces a lot of challenges but diseases is one of the greatest. 1 in 3 deaths of children under 5 years old are preventable by vaccines and 4 out of 5 children are immunised with the help of UNICEF.

Every year a lot of children dies from disease such as cholera, typhoid and diarrhoeas due to inadequate access to safe water and sanitation services and lack of poor hygiene practice and this is one the major causes of under-five mortality.

However UNICEF being the world’s largest vaccines distributor. They also support immunisation programmes in more than hundred countries to protect children live. When a certain country is going through natural disaster or any kind of epidemic disease, UNICEF is always there to provide vaccination campaigns.

Furthermore, UNICEF works with more than ninety (90) countries to improve children live through better water supplies and sanitation facilities in schools and communities by promoting safe hygiene such as practising hand washing techniques, making sure they do everything it takes to stop disease spreading and killing.


War and Conflict:

Countries like South Sudan, central Africa, Republic of Iraq and Syria. War and conflict has put lives of millions of children in awful danger and treat. These children having lost their homes, families and loved ones and even their own lives in some cases. As a result of this, most of this children become vulnerable to many other dangers such as diseases, malnutrition, violence, exploitation, they often become orphans and homeless children.

UNICEF are always there to provide lifesaving food, water, medicine, protection and psychological support to children whose lives have been ruined due to the effects of the war and conflicts. It also ensures that children caught up in war and conflicts gets the help they deserve in order to stay safe and strong.


Hunger and malnutrition:

Every human being needs food and water to survive. A lot of children are in danger because of inadequate supply of food and water. As a result of malnutrition a child dies every 15 seconds especially in parts of Africa. More children live with the lifetime effects such as physical disabilities and learning difficulties.

When a child is born, the first couple thousand days tends to be the most crucial days in their lives. And so if they do not get enough nutrients during those days, their brains and bodies are liable to not developing properly.

UNICEF helps mothers and communities to keep their children healthy and well nourished. It provides 80% of the emergency food that saves life. By making sure that children eat food that gives them enough nutrient they need in their body. This has helped cut the number of children that are badly affected by nearly 100 million since 1990. All this is because of the food provided by UNICEF.


Disaster:

Due to climatic changes, a lot of severe and frequent natural disaster, food crises and rainfall patterns changing are putting people especially children in danger. Natural disasters such as flood, earthquake, tsunami and typhoon results in children losing their homes, families and lives.

After any kind of disaster, children are left vulnerable to many emotional breakdown, exploitation and this make so people homeless in the case of tsunami or flood, or death in some cases where people are being engulfed into the ground in the case of earthquake.

However UNICEF as an organisation is always there to provide help for children that has gone through this terrible disaster in order to stay strong and focused and give them enough assurance that would encourage them they could still have the lives they never thought they would ever have again. With the help of the Government, people and UNICEF provides life-saving supplies for the children immediately after an emergency and also help the communities to help rebuild their homes, towns and schools or any damages caused as a result of the disaster.


Conclusion

After making child survival rates better than before, including all the above mentioned care being rendered to every vulnerable individual, UNICEF being a charitable organisation should be well publicised so that people and other less privileged or not well known communities and people can be reached by its good work.

I would also like to suggest that everyone should embrace this organisation and continues to work with it so that the sharing of the important responsibility of helping and keeping vulnerable people safe is achieved.

Bibliography

UNICEF. (2010, January 10). Retrieved from UNICEF: http://www.unicef.org/whatwedo/

UNICEF. (2014, January 12). Retrieved from UNICEF:

http://www.unicef.org.uk/mobile/about-unicef.html

volunteer now. (2010, 12 22).

safe guarding vulnerable adults

. Retrieved from

http://rqia.org.uk/cms_resources/safeguarding-vulnerable-adults-a-shared-responsibility-colour-nl.pdf

Page | 1

Locate an advertisement that portrays nursing in some way (this can be print or web-based, or TV)

Locate an advertisement that portrays nursing in some way (this can be print or web-based, or TV)

 

Locate an advertisement that portrays nursing in some way (this can be print or web-based, or TV) and address the following questions in a 500-750 word paper:

Whose message is this? Who created or paid for it? Why?
Who is the “target audience”? What is their age, ethnicity, class, profession, interests, etc.? What words, images or sounds suggest this?
What is the “text” of the message? (What we actually see and/or hear: written or spoken words, photos, drawings, logos, design, music, sounds, etc.)
What is the “subtext” of the message? (What do you think is the hidden or unstated meaning?)
What “tools of persuasion” are used?
What positive messages are presented? What negative messages are presented?
What part of the story is not being told?

Your paper should be in proper APA format, double-spaced and a Microsoft Word document. All sources should be cited and referenced appropriately.

Pulmonary Embolism as Manifestation of Right Atrial Myxoma


A case report and review of literature

Abstract

We present a case of a 55-year-old man who suffered from shortness of breath and syncope; he was sent to our department for suspecting pulmonary embolism. We proceeded Computed tomography pulmonary angiography (CTPA) and Transthoracic echocardiogram (TTE) , confirmed the diagnosis which was caused by right atrial mass. After the surgery the patient was diagnosed as right atrial myoma (RAM) with pulmonary myoma emboli without no adverse event. The residual emboli were partially improved after one month anticoagulation. We reported this case and review of the relevent literature to help clinicians improve the understanding of diagnosis and treatment of pulmonary embolism caused by RAM.

Key words: pulmonary embolism, right atrial myxoma, treatment

Pulmonary embolism, most commonly originating from deep venous thrombosis (DVT) of the legs, ranges from asymptomatic, incidentally discovered emboli to massive thromboembolism causing immediate death. PTE is a life-threatening disease with a high morbidity. Annually, as many as 300,000 people in the United States die from acute PTE, which is much more common in China at present than 10 years ago (1). About 50-70% emboli of pulmonary embolism originated from deep venous thrombosis (DVT), most of which in lower extremities. Such patients without DVT should screen occult cancer. Although cancer associated venous thrombosis was widespread described, the emboli from benign tumor are less mentioned (2). Majority of the atrial myxoma complicated pulmonary emboli are tumoral, thrombotic emboli were less reported (3,4). We report a rare case of RAM with a pulmonary localization mimicking pulmonary emboli.

Case presentation

A 55-year-old man was admitted to emergency room with gradually increased shortness of breath for 2 months, syncope and right chest pain for 6 hours. He had a habit of long time sitting and a history of 20 pack-year smoking, and stopped smoking 10 years prior to admission. Initial assessment revealed cyanosis and right breath sound decreased. No pitting edema in lower extremities. Laboratory tests showed ALT 52IU/liter; 93IU/liter; D-Dimer >10μg/ml; NT-proBNP 3544 Ñ€g/ml; Troponin I 0.49 ng/ml. Arterial blood gases revealed severe hypoxemia, oxygenation index was 89mmHg; Electrocardiogram showed S

â…

Q

â…¢

T

â…¢

. CTPA revealed right main (Figure 1a), both lobar(Figure 1b,1c) and segmental (Figure 1d) pulmonary arteries(PA) multiple filling defects; right atrium irregular mass(Figure 1d). TTE showed enlargement of right chambers and a right atrial 54*47mm mass attached to the top wall, clear margin, irregular and partial rough on surface, loose in internal structure, moving along with cardiac cycle, mild prolapse through the leaflets of the tricuspid valve and orifice of inferior vena cava, moderate regurgitation of tricuspid valves with mild pulmonary hypertension. Compressed venous ultrasonography showed negative in both lower limbs.

The surgical approach was through a medial sternotomy under extracorporeal circulation. The right atrium wall was opened and a gelatinous consistency tumor with necrosis, fragile, measuring 40*50mm, adhering to the inter-atrial septum (Figure 2), a 30*20*70mm tumor embolus in the right main PA, the distal end was near right upper PA. The tumor cells expressed CD34 and calretinin, and were negative for CK and SMA. The histopathological examination confirmed myxoma (Figure 3) in right atrium and right pulmonary artery. The patient was treated warfarin (target INR, 2-3) for 1 month. Repeated CTPA showed left lower PA filling defect with no improvement after 2 months (Figure 4c), right and other left PA filling defect resolved (Figure 4a, 4b). 2 years follow-up he was asymptomatic.

Discussion

Cardiac tumors are less common, most of which are from metastasis. The incidence rate of primary cardiac tumors (PCTs) in autopsy ranges from 0.02 to 2.8‰. 30-50% of PCTs are myomas, 75% in the left atrium and only 10-20% arising in the right atrium, which may developing from embryonic or primitive gut rests (5,6,7). Histologically, they consist of an acid-mucopolysaccharide rich stroma. Polygonal cells arranged in single or small clusters are scattered among the matrix.

The clinical manifestations of RAM may remain asymptomatic or appear with constitutional, obstructive or embolic symptoms according to the size, fragility, mobility, location of the tumor as well as body position and activity (5,8). Nonspecific constitutional signs, which present in 10-45% of patients with myxoma, are fatigue, fever, dyspnea, chronic anemia, weight loss, general arthralgia, and increase of IL-6, ESR, and CRP (8). Therefore the results of laboratory tests may mimic those for rheumatic disorders. These signs are more common for patients with large, multiple, or recurrent tumors, and usually recovered after resection (9). Pulmonary embolism of RAM fragments or thrombi from the surface may also occur, resulting in dyspnea, pleuritic chest pain, hemoptysis, syncope, pulmonary hypertension and right heart failure even sudden death. Acute abdominal pain was mentioned in two cases (10). Embolic event in cardiac myxoma is common, with the incidence ranging from 30% to 40% (5).

In the cases of RAM with pulmonary embolism, a smaller size, villous or irregular surface and multi-foci are most common factors associated with embolization (11). The duration period was ranging from 1 day to 3.5 years. The age of patients ranged from 17 to 76 years (mean age 42.8 years), with a higher incidence in women (20/35, 57%). In these cases RAMs are usually attached by a short pedicle to the inter-atrial septum (22/35), mostly in fossa ovalis, others are in free wall, crista terminalis, Koch triangle and multiple origins. Most of the patients were diagnosed with TTE (Transthoracic echocardiography), CT, transesophageal echocardiography (TEE) and magnetic resonance imaging (MRI), others were with angiography and autopsy. In almost all cases treatment was surgical with removal of the intra-atrial myxomas and the pulmonary emboli, which are usually tumoral. Majority of such patients recovered well after surgery. Four preoperative deaths, two postoperative deaths were reported. Right atrial thrombosis, transient ischemic attack (TIA), ischemic hepatitis and renal failure were the rare complication (Table 1).

TTE and TEE are the most commonly used diagnostic methods in the detection and initial description of atrial myxomas (23). TTE is nearly 95% sensitive for the confirmation of cardiac myxomas, and TEE reaches nearly 100% sensitivity (45). TTE facilitated bedside test to safely detect myxomas in fatal pulmonary embolism as in our patient. TEE produces explicit images of small tumors (1 to 3 mm in diameter), especially in fat patients with poor TTE images (46). The TEE also permits a clearer picture of the attachment of the tumor and more precise characterization of the size, shape, surface, inner structure and location of the mass (47). Although TEE is a semi-invasive diagnostic test with a very low rate of significant complications, lethal pulmonary embolism during TEE procedure has been reported (22).

Superior to echocardiography, multi-detectors spiral computed tomography (MSCT) and cardiac magnetic resonance imaging (CMR) are more accurate in determining the relationship to normal intra-cardiac structures and tumor infiltration into the pericardium, extension to adjacent vasculature and mediastinal structures, pulmonary arteries emboli and surgical planning (48,49). RAMs manifest as a low-attenuation intra-atrium mass with a smooth, irregular or villous surface on MSCT. Calcifications are seen in about 14% and are more common in right side lesions. Arterial-phase contrast enhancement is usually not apparent, but heterogeneous enhancement is reported on studies performed with a longer time delay (50,51). Varying amounts of myxoid, calcified, hemorrhagic, and necrotic tissue gives them heterogeneous appearances on T1 and T2-weighted images. Delayed enhancement is typical and usually patchy in nature. Steady state free preceesion (SSFP) sequences may slow prolapse through the tricuspid valve in diastole phase and can suggest the attachment point of a stalk lesion. Reconstruction of cine gradient recalled echo (GRE) images enables assessment of lesion mobility and attachment (52).


18

F-FDG PET/CT can help the noninvasive preoperative confirmation of malignancy (41). Mean SUV

max

was 2.8±0.6 in benign cardiac tumors and significantly higher in both malignant primary and secondary cases. (8.0±2.1 and 10.8±4.9). The SUV

max

of myxoma is ranging from 1.6 to 4. Malignancy was determined with a sensitivity of 100% and specificity of 86% with a cut-off SUV

max

value of 3.5. A weak correlation between the SUV

max

and the size of tumors is found due to the partial volume effect, cardiac motion and respirtatory movement (53). Angiography is an invasive investigation that presents an additional risk of inducing migration of the tumor and only suitable for suspected acute coronary heart disease (37).

Surgical removal of the RAM with pulmonary embolism is the first treatment of choice and usually curative (44,45). The crucial aspects of surgery are measures for bi-caval cannulation to prevent intra-operative embolism (27), en-bloc excision of the myxoma with a wide cuff of normal tissue, removal of fragments in pulmonary arteries, and conducted under moderate or deep hypothermia, low circulatory flow or total circulatory arrest based on the extent and sites of the emboli (44). Surgical treatment leads to complete resolution with low rates of recurrence and good long-term survival. The overall recurrence rate is about 1–3% for sporadic atrial myxoma (5,54), which grows an average of 0.24–1.6 cm per year. The risk of recurrence pulmonary embolism after resection has been reported to be 0.4% to 5.0% and interval from excision to recurrence is reported ranging from a few months to 8 years (55). The reasons of RAM recurrence include multifocal origin, incomplete surgical resection, familial disposition or abnormal DNA ploidy pattern. Postoperative annual TTE, V/Q scan for long-term observation should be followed up to detect eventual recurrence of new myxoma and pulmonary embolism. Excision of the recurrent lesions may be the only choice of treatment because of the poor role of chemotherapy and radiation (28).

Pulmonary emboli from RAM are usually tumoral, although discriminating myxomas from thrombi in pulmonary arteries is difficult. Daniel T et al (56) presented the first case of paradoxical pulmonary embolism in the presence of a left atrial myxoma withouingt intra-cardiac shunting, potentially secondary to a combination of hemolysis, hemeoxygenase-1 up-regulation, systemic hypercoagulability/hypofibrinolysis, and regional venous stasis. Pulmonary thromboembolism complicated to RAM improved by coumadin therapy in a refused surgery patient (40). In our case the surgery do not remove the right side emboli, while anticoagulation was helpful for residue emboli remission, which confirmed coexistence of myxoma and thrombi. We suggest anticoagulation may be the useful in unresectable myxoma with pulmonary embolism. The duration of anticoagulation in pulmonary thromboembolism is at least three months, but the course in patients with RAM is still unknown.

Conclusion

According to review of the literature, RAM may not be timely diagnosed, or even totally undiagnosed. Because of the fragile consistency of RAM, pulmonary embolism are the most common comorbidity and mortality disease, usually be fatal. Surgical removal of masses from the atrium and pulmonary arteries is almost uneventful. Although the association between right atrial myxoma and pulmonary embolism has been described, the presence of thrombi was less mentioned. We suggest anticoagulation may be a choice of treatment after operation, especially in incomplete resection cases. Annual TTE and V/Q are suggested for a period of 8 years when the risk of recurrence is reported.

Competing interests

The authors declare that they have no competing interests.

Differentiate consultation from supervision?

Differentiate consultation from supervision?

advance practice nursing

Consultation is a core competency of graduate nursing. Answer the following: 1st page.

1. Differentiate consultation from supervision?

2. are consultation and collaboration synonymous? Defend your response.

3. give an example on how you have seen the consultation competency practiced in your ICU floor nursing.

Explain if the practice followed the graduate competency criteria.

Remember references at the end as many as needed. Page 2:

1. Coaching and mentoring should be a core competency of nurses prepared at the graduate level Do you agree or disagree with this statement? Defend your response.

2. Based on family nurse practitioner specialization, identify one coaching activity that you can do in this advance practice role. What strategies would you employ for this activity?

3. Describe one mentoring activity you ,might complete with a mentor that would help you to acclimate to your new advance practice role. Should this activity be structured or unstructured?

remember your references using apa. In your discussion provide a substantive response with scholarly academic references using APA STYLE FORMAT. USE ONLINE LIBRARY RESOURCES journals, etc..AND use current book Advance practice nursing: an integrative approach. 5TH edition. Hamric, A., Hanson, C., Troy, F. C., & O’ Grady,

1. Why should we want to avoid criticizing anothers anger with statements such as- You shouldnt feel that way- or You have no cause for anger 2.Suggest how you might deal with an employee who r

1. Why should we want to avoid criticizing another’s anger with statements such as, “You shouldn’t feel that way,” or “You have no cause for anger?”

2.Suggest how you might deal with an employee who reacts with tears and denial to every criticism regardless of scope or importance.

3. Why should you avoid dealing with multiple complainers at one time? Is this not more efficient than meeting with them one at a time?

4.Why do you believe HIPAA makes it necessary for even one’s spouse to have written permission to learn one’s condition when hospitalized?

Just copy the question in google search and it will come up with the the book Umikers management skills Does not have to be long responses

Analysis of the Public Health User Fee Reforms in Malawi


RESEARCH PROPOSAL


Research title

: The political economy analysis of the implementation of public health user fee reforms in Malawi.


  1. BACKGROUND AND BRIEF LITERATURE REVIEW

The economic crises of the 1970s and 80s led many countries to undergo structural reforms that called for reduced public expenditure for basic services. The reforms resulted in the introduction of cost sharing on the part of beneficiaries (Lucas 1988). In several countries, user fees were imposed as a means to address recurrent costs problems and an extra source of revenue for previously “undervalued” services of professional providers. Countries responded differently to the introduction of user charges depending on domestic political risk and institutional capacity to efficiently administer the fees. With the reforms, public financing of health declined in many countries, and in some cases, private service providers seized the opportunity to fill the gap (Romer, 1986). Although the involvement of private service providers helped to meet demand for those able to pay, it limited access of the poor to the same services due to the prohibitive costs.

Over the past ten years, research on economic growth has demonstrated that human capital is a powerful force in the development process (Becker 1990). In consequence, a sustained increase in this form of capital is crucial for poverty reduction in low-income countries and for an ever rising standard of living. Health is one of the commonly used proxies for human capital – an unobservable magnitude or force that is part and parcel of human beings (Schultz 1960).

Developing countries are struggling to improve the lives of people living in both rural and urban areas. The big challenge in these countries is lack of resources and problems in allocating the scarce resources. Various governments have prioritized different sectors depending on the needs and demands of the people. Some have prioritized primary education and agriculture while others have prioritized mining and health sector. Developing countries have come up with different interventions purposed to cushion people and be able to manage the risk. Some interventions have taken the form of subsidy while others have taken the form of user fee exemption to mention but two (Schultz 1961).

These interventions sometimes are driven by politics, that is why for one to effectively intervene needs to understand the interplay of politics and economics in the developing countries. Depending on policy makers, some would prefer to implement subsidy programmes while others would have user fees exemption or both. User fees are charges one pays at the point of use. The stated interventions are good for the people but to the larger extent over burden the already struggling economy of the developing countries, (Litvack et al 1993). Consequently, government sectors suffer due to being underfunded which has resulted to poor service delivery defeating the whole purpose of subsidy or user fee exemption. Some countries, thus, they have resorted to meet the deficit through the introduction of user fees. For example, in respective of health for all, Malawi government offers free public health services to everyone in the country (ibid).

Through observation, the public health services in Malawi particularly those in bordering districts such as Mchinji, Nsanje, Mwanza and Mulanje face very stiff competition on health resources because the hospitals in these districts serve even those from the neighboring countries such as Zambia and Mozambique.

Currently with the growing population, government is failing to meet the demand of the free public health services which is manifested through the lack of medical resources in the hospitals. Lack of resources might be because the government has a limited tax base to finance the public health services. For instance, in Daily Times of 18th August, 2014 carried a story that Kamuzu central hospital had suspended all the booked surgeries because the hospital had no medical resources required to carry out operations in the theaters. Burns unit department also suffered the same. In such circumstances the introduction of user fee in public hospitals becomes not an option but a necessity. The user fees may therefore, help in three aspects within health service sector: improving efficiency by moderating demand, containing cost, and mobilize more funds for health care than existing sources provided


  1. PROBLEM STATEMENT

The aim of free public health services in Malawi was to bring equality and equity in accessing health services. It has been argued that with user fees in accessing public health services, the poor people could be disadvantaged. Axiomatically, healthy people make healthy nation and participate actively in the development activities. Defeating the aim of free public health services, it is the same poor people who are now struggling while the better off and even politicians use the private hospitals. Every person has got the right to good quality health, but the poor people in Malawi are now voiceless and spend painfully on the services that were meant to be free. The situation begs a question that are the public services in Malawi really free at all when a person is told to buy aspirin tablets in private hospitals or pharmacies while the public hospitals have given the medicine to undeserving individuals such as those coming from other neighboring countries e.g. Mozambique just because public hospitals in Malawi are free. Poor people are also voiceless and lack responsibility on the hospital resources for it is given to them for free. Hospital workers have been frustrated because their working environment is not conducive since they are forced to work even when they do not have resources and are sometimes frustrated due late or nor payment at all for the extra hours rendered.

Provision of quality health services is one of the social indicators of development. However, looking at the persistent resource shortages in the public health sector, Malawi as a country is far behind the expectation. Optionally, national policy makers in some countries such as Kenya and Mozambique thought to enlarge government revenue base through the introduction and implementation of user fee with an aim of improving services, for example, by improving drug availability and the general quality of health care and extending public health coverage. Therefore, the current study aims at undertaking the political economy analysis of the implementation of public health user fee reforms in Malawi. The study will be guided by the following sampled questions:

  1. What are the challenges towards the implementation of public health user fees in Malawi?
  2. What is the reaction of policy makers towards public health user fee implementation?
  3. Is user fee good option to finance public hospitals
  4. Can Malawi manage to embrace user fee policy (in terms of attitudes, willingness and capacity)
  5. How much is raised from the paying ward in the central hospitals, are the services different from the non-paying ward? If they are different, how do they differ? And how is money used. Has it brought any change?
  6. What are the problems that public hospitals meet?

  1. OBJECTIVES

Main objective: to undertake the political economy analysis of the implementation of public health user fee reforms in Malawi.


  1. SPECIFIC OBJECTIVES

    1. Exploring the historical discourse of public health user fee in Malawi.
    2. Determining the reasons of government failure to introduce and implement user fee in public hospitals.
    3. Analysing how people have been deprived of good health services through free public health services in Malawi.
    4. Comparing the challenges in managing the resources faced in the CHAM hospitals and public hospitals.
    5. Analysing stakeholders’ attitude, willingness and ability to embrace public health user fee implementation policy.

  1. HYPOTHESIS

    1. Poor quality of public health services can motivate public willingness to pay towards some improvement of the services
    2. Inadequate funding leads to poor public health services in Malawi
    3. Malawians are deprived of quality public health services through free public health services.
    4. User fee reform in public health services can lead to efficiency and equity in public health resources in public hospitals.
    5. Politicians wish to introduce public health user fee reform but are deterred by the fear of losing popularity

  2. METHODOLOGY


    1. STUDY DESIGN AND METHODS

The study will mainly use qualitative descriptive and analytical cross sectional approach. Objective 1 and 2 on public health user fee trend and government failure to introduce and implement the same respectively will use qualitative descriptive approach. Whilst objectives 3-5 on analysis of people’s deprivation of good health, comparison of challenges in managing resources and analysis of stakeholder’s attitudes respectively will employ qualitative analytical approach.


  1. STUDY SETTTING

The study will take place in Malawi, population

n

of people; the ministry of health headquarters in Lilongwe, Malawi’s four central hospitals,

n

number of district hospitals n community hospitals and n health centers. There are also CHAM facilities, private hospitals and NGOs (both local and international) that support health system. The study will focus in all central hospitals because they provide tertiary management care. The ministry of health, because it is the headquarters, some selected CHAM facilities in four regions and few selected NGOs in Malawi.


  1. TARGET POPULATION

Objective 1-2 will target key informants at the headquarters and in the central hospitals and the reviews of available literature in Malawi. Objective 3 will target the discharged patients in the central hospitals and some community around the selected hospitals. Objective 4 will target the health workers in CHAM and central hospitals. Objective 5 will focus on key informants in NGOs which work with health sector.


  1. SAMPLING STRATEGY

Since the study will employ qualitative design, hence, participants will be selected purposively.


  1. DATA COLLECTION PROCESS

Before data collection, consent will be obtained from the ministry of health head-quarters and all in-charges of the facilities where the study is going to take place. The research will be explained to the participants to seek their informed consent.

Data collection tools will be pre-tested, these will include interview guide for 1) discharged patients to find out any deprivation of their care, 2) health care workers to assess the challenges in resources 3) key informants to analyse their attitudes. And checklist to assess challenges faced by health care workers and patients deprivation of care.


  1. ETHICAL CONSIDERATION

In carrying out the proposed research, the concept of research ethics will not be ignored. All people involved in this research will have to give consent. No one is going to participate against his or her will but the research would prefer to have full participation from the participants and not partial. Attention will be deployed to make sure that people’s rights are not violated through this research. Participants will be told the aim of the research and everything crucial so that they should be able to give informed consent. Participants’ identity will not be revealed in the data presentation and analysis. However, upon request, some participants predominantly NGOs will have the copy of the research findings.


  1. DATA MANAGEMENT

Data will be transcribed from Chichewa to English then themes will be developed from which quantitative data will be analysed while quantitative part will be managed by SPSS. Data will be kept confidential unless strict measures are taken to access the same.


  1. PRESENTATION OF DATA

The data will be presented through quotes and where necessary tables and graphs will be used for the part of quantitative.


  1. THEORETICAL FRAMEWORK

The nature of the research demands SIDA’s Power Analysis framework. The introduction and implementation of public health user fee involves power of various stakeholders who have different powers of influence. The research then aims to analyse and gauge how much power Do these stakeholders have towards the introduction and implementation of user fees in public health services, (Shaw RP et al, 1995).

SIDA’s power analysis focuses on understanding structural factors impeding poverty reduction as well as incentives and disincentives for pro-poor development. Thus, health sector is a hub to development of which the poor have to be targeted. SIDA power analysis tool also serves to stimulate thinking about processes of change in terms of what can be done about formal and informal power relations, power structures and the actors contributing to it. The framework seeks to either deepen knowledge, facilitate dialogue, foster influence or feed into policy developing and programming of which in this case will be the introduction and implementation of user fee in public hospitals (Shaw RP et al, 1995).

In the same vein, political economy analysis also looks at the interaction of formal and informal institutions. The collected data will also be subjected to the critical analysis under the interaction of informal and formal institutions (ibid).

8.0

JUSTIFICATION OF THE RESEARCH

The current research is of paramount importance to the people of Malawi. The study will facilitate the improvement of public health services throughout Malawi. The big problem in the health sector is inadequate resources, consequently, the research is purported to carry out analysis of how public health user fee can be an alternative to financing public hospitals. The improvement in public health services entails healthy people who can actively participate in development activities. The success in the implementation public health user fee will help not to over burden the government because public health hospitals will be able to meet some needs through user fee, hence, the government will be able use the part of budget allocated to the health sector in other sectors of priority.

The study will provide an insight of development health sector and bring satisfaction to people especially those who use public health services. The study assumes that if the public health user fee reform is implemented, people will access the services of higher quality compared to the current situation in which patients are told to buy the prescribed medication in the private pharmacy because hospitals have no medicine. In this then, the implementation of user fee reduces the cost of accessing public health services in Malawi. No country can develop if the health services are poor. The vitality of the current study cannot be over emphasized, if it will be well done, Malawi as a country will register good health and social development.


REFERENCES

Becker, Gary (1991). A Treatise on the Family. Cambridge, Massachusetts, Harvard University Press.

Lucas, Robert, E. (1988). On the Mechanics of Economic Development. Journal of Monetary Economics 22(1): 3-42.

Pritchett, Lant and Lawrence H. Summers (1996). Wealthier is Healthier. The Journal of Human Resources XXX(4): 841-68.

Schultz, Theodore W (1960). Human Capital Formation by Education, Journal of Political Economy 68(6): 571-83.

Schultz, Theodore W (1963). The Economic Value of Education. New York: Columbia University Press.

Schultz, Theodore W (1961). Investing in Human Capital. The American Economic Review 51(1): 1-17.

Romer, Paul (1986). Increasing Returns and Long Run Growth. Journal of Political Economy 94.

Shaw RP, Griffin C. (1995), SIDA power analysis Washington DC: World Bank

Sophie Witter (2010) Mapping user fees for health care in high-mortality countries: evidence from a recent survey ; HLSP institute

Audibert M, Mathonnat J. 2000. Cost recovery in Mauritania: initial lessons. Health Policy Plan:

Chawla M, Ellis RP. 2000. The impact of financing and quality changes on healthcare demand in

Niger. Health Policy Plan: 76-84.

Lucy Gilson (—–)The Lessons of User Fee Experience in Africa Center for Health Policy, Department of Community Health, University of Witwatersrand, South Africa, and Health Economics and Financing Programme, London School of Hygiene and Tropical Medicine, United Kingdom.

Litvack J, Bodart C. ( 1993) User fees plus quality equals improved access to health care: results of a field experiment in Cameroon. Social Science and Medicine.

Mbugua JK, Bloom GH, Segall MM (1995). Impact of user charges on vulnerable groups: the case of Kibwezi in rural Kenya. Social Science and Medicine.

Moses S, Manji F, Bradley JE, Nagelkerke NJ, Malisa MA, Plummer FA (1992). Impact of user fees on attendance at a referral centre for sexually transmitted diseases in Kenya. Lancet


This research proposal was written by a student and is published as an example. See

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The Role of Heat Shock and Cold Shock Proteins in Hormesis


The Role of Heat Shock and Cold Shock Proteins in Hormesis

­­­ Life is full of good events as well as physically traumatic events. In addition to major accidents such as injuries, there are environmental conditions that can chronically threaten our well-being. Fortunately, the finely-tuned machine of the human body, along with every other living thing, is equipped with parts and methods to deal with these otherwise deleterious episodes. Heat shock proteins and cold shock proteins are two such examples of beneficial parts. As their names suggest, they are able to absorb the shock of the mildly or moderately stressful events of an organism’s being exposed to hot or cold temperatures. The concept of hormesis allows for such mild traumas to not merely be negligible in the harm caused but to actually benefit an organism. By this principle, heat shock and cold shock could actually improve an organism’s health. In this vain, some researchers have continued exploring therapeutic treatments that utilize hypothermia and hyperthermia either in clinical psychiatric populations or among patients for whom they hope to prevent from suffering neurological or psychiatric harm. Some of the mechanisms are variable among each individual, due to interactions with external and the internal biological environments. This paper first provides some basic explanations of the biological components known as heat shock proteins and cold shock proteins.


Heat Shock Proteins

Within and outside of cells, heat shock proteins have the important role of facilitating the folding of proteins (Zininga, Ramatsui, & Shonhai, 2018). They also are activated as part of the heat shock response. Because there is an ideal temperature range that each organism requires for survival, the heat shock response is activated by even a slight rise in temperature (Richter, Haslbeck, & Buchner, 2010). This response is mainly intended to prevent the unfolding of proteins within an individual animal cell, which could result in protein entanglement and general aggregation, all of which hinder healthy cell function (Richter et al., 2010). Furthermore, heat can rearrange and damage the fibers that make up the cytoskeleton of the cell, a process that threatens the structural integrity of the cell (Richter et al., 2010). Thus, heat shock proteins play an important role in preserving cellular structure.

Despite their specialized role, heat shock proteins do not have a monolithic function. There are several types of heat shock proteins, and depending upon the type and concentration, they can function in a pro-inflammatory or anti-inflammatory manner, such as heat shock protein 70 (Zininga et al., 2018). As such, these proteins can serve as markers of disease (Zininga et al., 2018). In addition to serving as markers, the action of these proteins can provide an overall hormetic protection to the cells of the body.


Heat Stress and Hormesis

As mentioned above, the principle of hormesis demonstrates how mild levels of substances or events that would otherwise be toxic can actually improve the life of an organism (Le Bourg, 2009). This makes sense, we see this in many areas of life, such as with resistance training exercises, vaccines, and mild joking insults among friends. Regarding biochemical toxins, low-level stressors actually have the effect of extending life in lower-order animals (Haigis & Yankner, 2010). When it comes to temperature differences, heat shock proteins have been shown to affect immune system function; however the mixed results from research indicates both the species being studied and the concentration of protein levels determine whether the effect will be supportive or suppressive (Zininga et al., 2018). And, as mentioned above, since heat shock proteins are associated with inflammatory response they can be helpful as markers identifying either the presence of inflammation or the loss immune function, such as in chronic inflammatory diseases (Borges et al., 2012).

There is a hormetic effect that heat shock proteins have on a specific but important practical activity: dentistry. A pretreatment of heat was given to patients whose level of heat shock protein 70 were experimentally manipulated undergoing dental procedures, and the patients with the higher levels of the protein exhibited less overall movement (Marciniak et al., 2019). These findings demonstrate the protective role of the heat shock proteins maintain cellular structures even under macromovements of orthodontic work (Marciniak et al., 2019). These protective effects indicate the multiple needs and benefits of heat shock hormesis.

Despite their protective functions, the specific circumstances of heat shock proteins within an organism can determine how beneficial or even whether heat shock proteins are helpful. For example, in individuals with Huntington’s disease, heat shock protein 90 (HSP90) has been shown to be associated with suppression of brain-derived neurotrophic factor, which is an important chemical for neural cell life (Orozco-Díaz et al., 2019). There are equivalently valuable components that serve as markers for pre-cancerous cells (LLeonart, 2010): cold shock proteins.


Cold Shock Proteins

Similarly to heat shock proteins, cold shock proteins are activated when cells are exposed to even mild relatively cold temperature (Rzechorzek, Connick, Patani, Selvaraj, & Chandran, 2015). Also similarly to heat shock proteins, cold shock proteins serve as a chaperone, meaning they facilitate folding of other proteins in order to preserve their structure and function (Goroncky et al., 2010).

When activated, some cold shock proteins facilitate protein synthesis, sometimes even to a dangerous degree, leading to cancer growth (LLeonart, 2010).

But these proteins also prevent unnecessary cell death (Rzechorzek et al., 2015).

Cold shock proteins can facilitate the preservation of cells when they are in a process of receiving less oxygen and other nutrients (Polderman, 2009). This is particularly useful in situations during which there is not much oxygen or nutrients available to the cells, for whatever reason, but after which they will be made availab


Cold Stress and Hormesis

There are several physiological mechanisms, such as the production of testosterone and adrenaline as well as numbing, that allow for a person to enjoy the benefits of being exposed to cold temperature (Kyriazis, 2010). Just like heat stress, cold stress has been demonstrated to have an effect of age extension (Kyriazis, 2010). Some researchers indicate that merely introducing chemical compounds that are associated with cooling into a body can instigate the benefits of the cold shock process (Kyriazis, 2010).


Clinical Applications

There are several ways that the body of research involving both heat and cold shock mechanisms can be applied to clinical psychiatric populations. One way that hypothermia therapy is already used is with sufferers of cardiac and brain events (Delhaye, Mahmoudi, & Waksman, 2012). While this medical intervention only directly involves cooling of the body to near-freezing temperatures, it activates cold shock proteins, which, as mentioned above (Polderman, 2009), can help stop damage due to traumatic rapid changes within the cell. Hypothermia treatment slows the metabolism of the brain, allowing for further treatment to be given, all the while preserving the existing neurological state from further harm (Delhaye, Mahmoudi, & Waksman, 2012).

Recognizing the benefits of hypothermia treatment, an application has been introduced for preventing epileptic seizures after the occurrence of brain injuries (Atkins et al., 2010). However, hypothermia is not an all-encompassing treatment for every malady. Some research indicates that ice-bath therapy for athletes is not significantly more effective than active recovery from workouts and injuries (Allan & Mawhinney, 2017).

Another application of heat and cold shock involves treating clinical depression. Whole-body hyperthermia, in other words, a sauna experience that heats up the body, has been shown as an efficacious treatment for major depressive disorder (Janssen et al., 2016). In rat studies, the combination of a small dose of antidepressant with hyperthermia has shown to alleviate depression symptoms (Hale et al., 2017). This is especially promising for the subject of pharmacological interventions, due to the complications associated with standardizing drug treatments (Hale et al., 2017).


Conclusion

It is clear that heat shock proteins and cold shock proteins are important in regulating cellular function when organisms are exposed to heat or cold. They seem to function as part of the biological system that copes with stressful environmental conditions and helps the organism become stronger and healthier as an outcome, all of this being known as hormesis. What is not clear is the specific hot and/or cold treatment that would be appropriate for treating and individual with various physical and mental ailments. Future research could indicate optimal amounts of hot or cold as well as effective combinations of hot and cold (contrast therapy). Caution must be exercised when designing studies, as there have been demonstrable adverse cognitive and emotional effects of introducing the variable of cold temperature in an already-stressed population, such as military trainees (Vartanian et al., 2018). In the realm of treatments, each individual has their own preferences, and different types of people or subpopulations may respond to different treatment methods. For example, certain sufferers of trauma or overly intellectual individuals may not want to engage in a physical modality like whole-body hyperthermia for depression. They may have intellectual concerns, emotional pain, or physical aversions to such a physiologically-demanding situation. Yet once they experience the benefits of hyperthermia or hypothermia, their physiological experiences might lead them to reevaluate their position on what could be a positive experience in their present and future treatment of personal physical and psychological issues.

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Unconventional Beauty Treatments by Celebrities

In today’s world, in order to achieve recognition in a particular field that you are pertaining to, the first and the foremost thing that counts is ‘the persona’ with which you carry yourself! Be it Multi National Companies or small scale companies, one of the most crucial things that can get you one step closer towards achieving your goals is having a good and magnificent personality. You ought to look presentable in any case whatsoever! And with regard to the celebrities in the Hollywood and Bollywood fraternity, it goes without saying as they have no other choice but to look beautiful and handsome in order to make a living!

These celebs come up with the most queer beauty treatments ever! Recently, there was an article published in one of the most well known newspapers about these most bizarre of the beautifying treatments undergone by celebs. What we need to understand and assess is that, how beneficial are these so called beauty treatments from a scientific and a medical point of view! Let’s have a look on these various ‘freakish beautifying treatments’.


  1. Liquid Gold Facial:

The heart of Liquid Gold, Seabuckthorn, was known for many years in northern states, as a skin care remedy and nutritional supplement. The berries of this shrub are always been associated with regeneration as they are rich in vitamins and nutrients. The oil of these berries assist in combating dry skin, visible fine lines, wrinkles and various signs of early ageing. These yellow-orange berries comprise of more than 100 nutrients, bioactive substances like phytosterols, water soluble vitamins (B1, B2, C, P, Folic acid, K) and fat soluble ones such as A, E and EFA (80-95% essential fatty acids), free amino acids, alpha and beta carotenes etc.

The Hollywood supermodel Bar Refaeli lately got a Liquid Gold Facial done which is also favored by Ayurveda since it is said to possess anti-aging properties.

When we look at this from a medical point of view, Liquid Gold is a strong resurfacing and firming treatment in order to reduce wrinkles, pigmentation and sun damage. This formulation is fortified with silk proteins, licorice extract and Glycolic Acid. It increases the skin’s metabolism, thereby adding on to tightening the enlarged pores and makes the complexion brighter and clearer.

Also, this formulation is immediately absorbed by cell membranes, reinstalling a golden glow to even the most lack-luster skin. It helps to fight hyperpigmentation, acne, wrinkles, fine lines and large pores thereby making you look young and evergreen.

There are no evidences available in form of articles or papers to prove the authenticity of this liquid gold facial.


  1. Facelift tape:

Lady Gaga uses facelift tape in order to pull the skin around the cheekbones and neck to look younger.

As per the experts, medically it is just not advisable to do daily face taping since it could lead to internal scarring, which may give rise to poor absorption of nutrients to the skin and early ageing. Moreover, doing face-taping everyday may cause the facial muscles to loosen, causing wrinkles and fine lines to appear earlier than usual.

There are some benefits of using a facelift tape as well. Like for example, if applied correctly, it can make a drastic change in the way you appear, only till the tape is in place! Also, it’s much reasonable as compared to surgeries and even some wrinkle creams. It can also prove to be beneficial to those celebs who are willing to go for a facelift surgery as it will give them an idea of what they will look after they have undergone the surgery and hence assist them in making a better decision in such a case.


  1. Japanese nightingale droppings facial:

This does sound nasty. But Tom Cruise vouches for this ‘bird poop facial’. Making a preparation of nightingale droppings, rice bran and water and rubbing it on the face, makes his face look shiny which contributes in making him look good as ever! This ‘nightingale poop facial’ which is also referred to as “Geisha facial” originates from Japan. Hence the name, “Japanese Nightingale Droppings Facial”. It is said to carry out exfoliation of the dirt from the skin causing it to appear shining bright and squeaky clean.

There are proclamations that the powder made from the excreta/faeces of Uguisu bird (which is used in Geisha Facial) has properties which provide multiple skin benefits. It may be useful for cleansing skin pores, whitening skin pigment of dark spots and discolorations from scars and sun spots, balancing and evening out and thus making the skin tone brighter. It also helps in healing and re-energizing of the skin which has been hampered because of the exposure to sun and aging. This powder is fit for oily skin, rough and aging skin, although it might not be suited to a skin type that is sensitive and prone to allergies.

There are no evidences to prove that it works or vice versa. All the so called “skin-gains” are obtainable in a variety of other skin products. We might hear of people using human faeces in future for skin treatment! That’s so sickening!


  1. Mayonnaise as a moisturizer!

Past years’ legend, Joan Crawford was said to make use of Mayonnaise to moisturize her skin and hair. This is really like taking your breakfast “spread tad bit seriously!

Taking into consideration the medical background, the chief ingredients in Mayonnaise are soya bean oil and eggs, which make it a potent treatment for dry facial skin. Mayo also comprises of vinegar, which helps in encouraging the turnover of skin cells, leaving the face feeling as if it has been exfoliated. Experts say that doing a gentle mayo massage on skin daily may help boosting up skin’s moisture.

Mayonnaise is said to be the possessor of moisturizing properties that extend beyond your skin. It is also observed to be a good hair conditioner as it gives a healthy shine to the hair.

But it would be much preferable to limit the mayonnaise to just your bread and instead make use of so many easily available wonderful hair cosmetics for giving that shine to your hair!


  1. Snake Venom as a replacement for Botox!

Snake Venom is the first choice for Katy Holmes as a replacement for Botox injections.

It seems that, she believes that this synthetic venom product has some kind of ‘muscle-shocking’ effect. It smoothens out the wrinkles and relaxes the muscles of the face.

When we look at this from a medical point of view, we can see that Scientists firstdiscovered a link betweenanti-agingand the paralysis-inducing properties ofviper venom,a few years ago. If thevipercould send its victims into a permanent stupor with itsvenom, they hypothesised thatperhaps the same science could be used to tamecrow’s feetandforehead furrows

.

The synthetic venom like counterpartSYN-AKEisatopical synthetic tripeptidewhichwhen applied to the skin, relaxes the “frowning and grimacing” muscles that lead todeep wrinkles

.

Clients of the Sonya Dakar clinic in Beverly Hills line up for thesesnake-venom facials

,

whileHollywood gossip sitesproclaimGwyneth Paltrow

’s

love & beliefforDakar’s UltraLuxe-9 Age Control Complex($190), aSYN-AKE-infused skin cream.

But there is absolutely no evidence or any independent medical research to prove the authenticity of the same.

Bee venoms have been used as a replacement for Botox treatment. The research has shown that this product contributes in producing natural collagen, a special kind of protein that provides elasticity to the skin cells and keeps the skin young. To add on to it, increases the number of keratinocytes – special cells, protecting them from getting influenced by certain harmful extrinsic factors like dehydration, agents of infectious diseases, ultraviolet (UV) radiation.


  1. De-puff with Piles cream!

Sandra Bullock believes that haemorrhoid tube works wonders to tighten up facial skin.

These haemorrhoid creams comprise of vasoconstrictors – which are responsible for shrinking the blood vessels. This is helpful when it’s about haemorrhoids, since there are swollen veins, but not so helpful when it concerns sensitive area below the eyes. As a matter of fact, certain ingredients in these creams may cause irritation in the eyes and worsen the situation. Also, there’s never been any convincing or high quality medical study to prove the effectiveness of the same. Hence, not being enthusiastic about this choice will be the best thing to do.


  1. Shine with red wine!

Actress Teri Hatcher pours Red Wine in her bath which helps softening her skin.

Studies have proved that there are certain ingredients present in red wine such as the tartaric acid, an alpha hydroxyl agent helps in exfoliation of the skin, thereby making it softer.

Drinking red wine is also beneficial as because of the antioxidants present in red wine, the skin is prevented from ageing.

What we can gather from all this is that, when it comes to your skin particularly your face, dare not take chances! Some of these bizarre treatments by celebrities do have a scientific base and some kind of possible reasoning but not all. Hence, consulting the expert Dermatologist and/or Facial Plastic Surgeon for such skin treatments is always advisable.

References:


Celebrity Beauty Secrets Makeover Tips


http://www.theestheticclinic.com/dr-debraj-shome.html

Child Obesity in Canada: Strategies for Intervention

Child Obesity in Canada


Immediate Action Needed for a Better Future

Executive Summary

Obesity is a condition that there is excessive body fat which leads to increased morbidity and mortality. Obesity puts children at significant risks for not only health problems such as cardiovascular diseases, diabetes, and cancers, but also mental and societal issues such as stigma, discrimination, social exclusion and decreased academic performance.

Obesity in Canada has become a leading public health concern. The prevalence of childhood obesity has increased five-fold from 1981. Currently, there are approximately 600,000 obese school-aged children countrywide. Obesity costs the nation approximately $1.27 to $11.08 billion per year just in health care.

Obesity is preventable. Promotion of healthy eating and active lifestyle is considered the most effective measure targeting childhood overweight and obesity. There are efforts to tackle this problem from federal, provincial and territorial governments, community, and school boards. However, they are not enough to end the obesity epidemic. There is still no nationally standardized school nutrition policy, resulting in different interpretation and implementation of school nutrition policies for our children across the country. The federal, provincial and territorial governments could work together to fix this. In addition, the federal government has attempted to tackle childhood obesity by the Child Fitness Tax Credit (CFTC) program since 2006. However, the CFTC does not prove to be effective and achieving its objectives. There is also a need to review and revise this initiative accordingly.

School-based intervention is proved to be effective in modifying dietary habit and promoting active lifestyle. Reduction of overweight and obesity among students has been observed in the APPLE School program in Alberta. The potential obesity associated cost savings for our nation would be up to 330 million per year if this model was scaled up countrywide.

Problem Definition

Obesity is a condition involving an excessive amount of body fat. Obesity is normally determined by a simple index of weight-for-height called body-mass-index (BMI). In adults (20 years and older), a BMI of larger than 25 and 30 is considered overweight and obesity respectively [1, 2]. For child and teen (2 to less than 20 years), the United States Centers for Disease Control and Prevention (CDC) recommends a BMI-for-age percentile scale, in which BMI-for-age from 85% to 95% tile and 95% tile and higher is considered overweight and obesity respectively [3]. Although the causes of overweight and obesity are complex, the fundamental reason is the imbalance between energy consumed and expended. This is normally caused by increased intake of energy-excessive foods and sedentary lifestyle.

Obesity is the most commonly seen disorder in children in developed world. Childhood obesity puts children at significant risks of many health problems. This can include chronic and fatal disease like type-2 diabetes, various types of cancer and cardiovascular disease [4-6]. Obesity also places children at a higher risk of stigma, discrimination, social exclusion and decreased academic performance in school [7]. However, scientists suggest that the greatest health problems will be seen as the present generation of overweight and obese children becomes the next generation of adults [8], probably with more social and medical problems and a shorter lifespan than their parents.

Childhood obesity in Canada is on the rise and has become a leading public health concern. Currently, more than a quarter of Canadian children and youth are overweight or obese. Obesity and its resulting health effects are extremely expensive. Obesity is theoretically responsible for 9% of deaths among adults aged 20-64 years [9]. The cost of obesity in health care ranges from $1.27 to $11.08 billion per year [10].

The objectives of this policy brief are to:

  • Promote awareness of childhood obesity problem in Canada and urge for immediate policy actions from federal, provincial and territorial governments, and school boards;
  • Make recommendations on interventional policy actions to tackle obesity problem.

Only peer-reviewed publications, health professional agencies’ (CDC, WHO) materials and government reports are used to provide evidence and supportive argumentation.

Review of Evidence

Canada, like many other developed nations, is facing an emerging epidemic of overweight and obesity. Scientific evidence indicates dramatic increases in both overweight and obesity over the last decades, particularly among children. Prevalence of childhood overweight has tripled since 1981 while that of obesity has increased five-fold during the same period [11, 12]. Presently, there are approximately 7 million obese adults and 600.000 obese school-aged children in Canada [12]. If current trends continue, 55% of Canadians will be either overweight or obese by 2020 [13] and up to 70% of adults aged 40 years will be either overweight or obese by 2040 [14].

Childhood obesity is driven by a number of factors, including personal, interpersonal factors, organizations, community and a broader social environment [15]. It is a complex and multifaceted web of reasons. Thus, a multidimensional and coordinated approach is needed to tackle this health problem. Among many possible interventions, promotion of healthy eating and active lifestyle is considered the most effective measure targeting childhood excessive body weight [16].

Junk food and sugar-added beverage provide excessive calorie intake while they lack nutritional value. However, this kind of food is still available in school vending machines or cafeterias in a number of provinces. Further, there is no standard policy on school nutrition, especially those related to vending machine foods, across provinces and territories of Canada. While New Brunswick and Ontario have mandatory regulations to ensure that only healthy foods are available at school environment, some others also have but do not cover all levels of education or have weak nutrition standards, which allow sale of high fat and high salt foods [17]. Apparently, the differences in school nutrition policies create unequal schooling environment for our children across Canada.

It seems agreeable that any obesity prevention program should include some form of physical activity advocacy and education [18]. The Canadian Paediatrics Society recommends a healthy living for children and youth, in which children and adolescents are recommended to “increase the time that they spend on physical activities and sports by at least 30 min/day, with at least 10 min involving vigorous activities” [19]. In addition, promoting physical education in school has proved to be effective and is required in a number of places. Arkansas State in the United States mandates that every student in kindergarten through grade nine receive no less than one hour of physical education instruction per week for every student who is physically fit and able to participate [20]. For a maximum effectiveness, physical activities should be promoted at both community and school levels to create a continuum of active living from home to school and vice versa for our children.

Possible Ways to Address the Problem

Overweight and obesity are preventable [2]. Even though there are many policy options, this paper opts to highlight three possible solutions for federal, provincial and territorial policymakers, as well as school boards to win the fight against childhood overweight and obesity.

Development of a national school nutrition policy

Even though education and health rest with provincial and territorial responsibility, a policy from Health Canada can help shape common standards of school nutrition nationally. Such a policy can ensure that our children have access to heathy and nutritious foods while they are in school in all provinces, and hence provides better protection to our children in fighting against overweight and obesity. This can include, for example, nationally nutrition standards for foods provided in cafeterias, vending machines, and at school special events. This national policy should be mandatory and implemented at all levels of education. Provincial and territorial governments could issue additional school food-related policies to further protect their population. However, the national policy requirements should be adhered and kept as minimum standards. School boards and provincial, territorial health authorities will be responsible for implementation and monitoring of these policies.

Revision of Child Fitness Tax Credit program

Since 2006, the federal government has actively attempted to tackle childhood obesity by introducing Child Fitness Tax Credit (CFTC), in which parents can claim up to $500 to alleviate participation costs when they register children into eligible physical activity programs [21]. However, research has shown that this program does not meet its objectives. CFTC appears to provide little to no benefit to those who cannot afford physical activity program cost and carry that burden until the end of the tax year [22] and those who have no taxable income. Therefore, the CFTC has little impact on physical activities of children in low income families, who most need it. As overweight Canadians in low income households are 40% more likely to be obese than those in high income category [14], the CFTC has failed its childhood obesity prevention. Thus, there is a need to review and revise this initiative, so every Canadian kid has an equal and better chance of participating in physical activity programs.

Implementation of school-based intervention program

School is an ideal place for childhood overweight and obesity prevention intervention as children spend a large proportion of their time at school. There is strong evidence supporting school-based intervention. A review of 16 school-based childhood obesity prevention programs in Chile, Belgium, United Kingdom and the United States shows that a positive change of dietary habits is highly achievable [18]. Specifically, the Alberta Project Promoting Active Living and Healthy Eating (APPLE) School program has proved that an intervention on healthy nutrition and active lifestyle in schools has resulted in reduced overweight and obesity in students. Currently, there are 40 APPLE schools in Alberta. If this school model was to be scaled up nationally, the potential cost savings for Canada would be $150 to $330 million per year [23].

Recommendation

School-based program is effective in preventing childhood obesity and thus reducing comorbidity and health spending in the long run. This approach has an advantage of reaching almost all children in the community. In addition to health benefits, it may improve student academic performance and provide additional social benefits. Further, it establishes healthy behaviors at early stage of life that can lead to life-long healthy habits [16].

Given the complex nature of determinants of childhood overweight and obesity, school-based prevention intervention should be guided by behavioral theoretical frameworks. It is also worth to note that involvement of school food program and parent influence is the key to success. It has been shown that parent involvement is an important component of school-based intervention [18].

It would not be realistic to expect immediate results. Notable reduction in childhood overweight and obesity can only be seen in years with intensive and diversified interventions [18]. However, if no action is taken now, our children’s lives are at risk of being deteriorated by social and medical complications of excess body weight in the years to come.