1.A)How does the packaging of bacterial DNA differ from that of eukaryotic DNA? Why does it differ?

1.A)How does the packaging of bacterial DNA differ from that of eukaryotic DNA? Why does it differ?

B) How does the packing of eukaryotic DNA differ in interphase and metaphase? Is this difference related to the different roles of DNA in interphase and metaphase?

C) Illustrate the structure of the nucleus and its envelope.

D) How are macromolecules transported across the nuclear envelope? Describe the structure that regulates nuclear membrane permeability.

E)Describe the appearance, location, and function of the nucleolus.

STREP THROAT

STREP THROAT

Subject: Nursing
Make up a pediatric patient profile please….
A SOAP note including diagnosis and any pertinent diagnostic tests. In addition to the subjective and objective findings include: past medical and surgical history, review of systems, family history, assessment, anticipatory guidance, health follow-up recommendations. Include a brief discussion of the pathophysiological processes involved in the patient’s diagnosis. List the ICD9 codes for the diagnosis and differential diagnoses.
You must also complete at least one prescription for each case study.
Remember to cite each of your references using APA format.
You will need to review current literature and use sources in addition to the course text books to complete this assignment.
Nationally recognized professional resource guidelines including National Guidelines Clearinghouse are an important resource for your practice in implementing disease specific treatment. You must utilize at least one national guideline and other research references in your case study. If you do not, points will be deducted.
Explain the rationale for drug selection as a treatment recommendation. As is any patient interaction, do not, by action or omission of action, cause harm to your patient.
Case studies are intended as an adjunct learning opportunity to assist you in understanding the complex nature of assessing health conditions, prescribing medications, making treatment/follow-up recommendation, and gaining understanding of billing practices within the role of advanced practice nurse practitioner.

1. Answers reflect concise but thorough review of the course content and relevant literature on the subject matter being addressed.

2. Reflects concise Nursing Interventions including Pharmacological and Non-Pharmacological Interventions.

3. Reflects critical thinking and clinical decision making which is individualized to meet the patient’s assessed needs.

4. Reflects application of evidence based practices

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Risk management and transparency policies

Risk management and transparency policies

Subject: Nursing
How an executive officer, proactively manage system change and create a transparent organization through risk management policies, plans, and procedures?

What tools can be implemented to ensure organizations such as Healing Hands Hospital and physician practices are meeting the policies and procedures set forth by CMS?

What tools can be implemented to ensure organizations such as Healing Hands Hospital and physician practices are meeting the policies and procedures set forth by CMS?

Paper , Order, or Assignment Requirements

For this assignment, write a 2-3 page report that you will deliver to Mr. Magone on how the new Centers for Medicare and Medicaid Services (CMS) initiatives and regulations will impact the organization’s revenue structure. In your presentation, address the following questions:
• Why did CMS become more involved in the reimbursement component of health care? How does CMS’s involvement impact the reimbursement model for Healing Hands Hospital and other health care organizations? If CMS reimbursement regulations for Medicare and Medicaid change, does it follow that other insurance providers change their policies on reimbursement?
• What tools can be implemented to ensure organizations such as Healing Hands Hospital and physician practices are meeting the policies and procedures set forth by CMS?
• Identify 3 tools from the CMS Web site that are helpful in meeting the requirements for Medicare reimbursement set forth by CMS.

What is the nurse’s role in nursing research at the Associate’s Degree in Nursing (ADN) level versus the Bachelors of Science in Nursing (BSN)? How do these roles compare to a Master’s of Science in Nursing (MSN), PhD, and postdoctoral levels of education

What is the nurse’s role in nursing research at the Associate’s Degree in Nursing (ADN) level versus the Bachelors of Science in Nursing (BSN)? How do these roles compare to a Master’s of Science in Nursing (MSN), PhD, and postdoctoral levels of education?

 

1.In your opinion, what has been the most significant event, individual, or development in the field of nursing research? Describe the event, individual, or development. How did it influence nursing research? (1st page)

2.What is the nurse’s role in nursing research at the Associate’s Degree in Nursing (ADN) level versus the Bachelors of Science in Nursing (BSN)? How do these roles compare to a Master’s of Science in Nursing (MSN), PhD, and postdoctoral levels of education?(2nd page)

3.What are the main differences between qualitative and quantitative research? Under what circumstances is each type of research most appropriate? Support your answers with specific examples. (3rd page please use a reference for this question.)

CREATE A NEW 2010 OPERATING BUDGET BASED ON THE LABOR DECISION YOU SELECT FROM THE NURSING STATISTICS MEMO.

CREATE A NEW 2010 OPERATING BUDGET BASED ON THE LABOR DECISION YOU SELECT FROM THE NURSING STATISTICS MEMO.
Part 1 – 2010 Operating Budget Review the “2009 Budget Issues – Nurses” file in the Patton-Fuller Community Hospital Virtual Organization (accessed via the University Library).

Decide which of the two highlighted options you will implement from the Nursing Statistics memo of the “2009 Budget Issues – Nurses” document.

Create a new 2010 Operating Budget based on the labor decision you select from the Nursing Statistics memo.Use your Week Five Health Care Budget assignment as the foundation to develop your new projected budget.

Part 2 – Analysis Paper Write a 1,050- to 1,400-word paper in which you address the following:

Discuss decision-making processes in creating a budget.
Explain the role of variance analysis in maintaining an operating budget.
Differentiate between managerial accounting and financial management.
Explain generally accepted accounting principles applied to the health care industry and how they are applied to your Operating Budget Projection.
Discuss the decision between the two labor alternatives facing the management of PFCH and the annual cost increase of each.
Make a recommendation about which labor alternative should be chosen.
Justify and analyze the labor decision that you recommend. Your justification should present numbers related to fiscal management including how each decision affects the 2010 Budget Projection.
Analyze the effect of your decision on the operating budget, including: The opportunity cost of your recommendation How your recommendation affects employee satisfaction How your recommendation affects patient care and patient satisfaction
Cite a minimum of 4 sources. Format your sources according to APA guidelines. Must pass plagiarism checker!

Health Care Management and Information System in NHS London


Analysis o


f the Health Care Management and Information System in NHS London.


Virender Singh


Research Proposal MBA


Table of Contents

Rational of Research…………………………………………………………………………………………………..3

Specific Aim………………………………………………………………………………………………………………3

General Objectives……………………………………………………………………………………………………..3

Literature Review ………………………………………………………………………………………………………4

Statement of the Problem ……………………………………………………………………………………………5

Scope of the research…………………………………………………………………………………………………..6

Research Methodology…………………………………………………………………………………………………6

Significance of research ………………………………………………………………………………………………6

References………………………………………………………………………………………………………………….7


Rational of Research

A Management Information System (MIS) gives data that is required to oversee associations effectively and successfully. MISs are not just computer systems, these systems include three essential segments: engineering, individuals (people, groups or associations), and information for decision making. Assessment is one of the beginning steps in any planning process and one worry of evaluation is recognizing nature of problems, their magnitude of severity, conveyance and patterns. It serves to focus quality and shortcomings of the current existing system. Evaluation is an efficient collection and investigation of information required to make decision, a methodology in which most well-run projects captivate from the start. Enhancing any data framework implies as a matter of first importance distinguishing qualities and shortcomings of existing framework in order to concentrate on areas functioning the least. Healthcare Management Information System (HMIS) appraisal is then the early step in the procedure for strengthening and enhancing it so it is paramount to identify data issue at its root and arrangement for more coordinated methodology for development at each one level.


Specific Aim:

To assess the current Health care Management Information Systems to find out its focus quality and shortcoming.


General Objectives:

  1. To create solutions for improving the current issues, improving existing framework to have well reported framework in order to meet the demand of end user.
  2. Developing strategies to enhance automated documentation of information.
  3. Developing strategies so that the employees can use information legitimately for proper planning and surveying the current circumstances.
  4. Encouraging the use of Health care Management Information System for enhancing clinical consideration.
  5. Evaluating the capacity of front line employees for the best possible utilization of electronic information system.


Literature Review

Information needs to be decently characterized at each level in the event of information collection, processing of data, information transmission and there ought to be fitting feedback system. Computer technology can enormously improve and facilitate the data processing storage and retrieval so it is critical to upgrade computer systems, have proper security and proper insurance of the software.

There ought to be constant appraisal on relevant timeliness and use of data at all levels. Planning ought to be contrasted with the actual performance in order to reflect changes and timely feedback the significant obstacles to viable and enhanced healthcare administration in the third world countries as absence of data is for the most part present. Well designed routine information framework guarantees that services are conveyed as per the standard as decision making methodology uses quantitative and objective data. Health information system is essentially needed for three major services. These include patient management, management of health units and management relating to health systems.

Healthcare Management Information System exists to bridge the gap between when a patient becomes sick and the response of health service providers. This is due to the fact that initially health care information systems were in existence only to gather data relating to the problem the patient is having, or in some cases a disease and health services outputs; however later on the health information systems are becoming the part of health systems and hold paramount significance in the planning and decision making of healthcare services.

The WHO theory is that the advancement of judiciously organized information system closely adjusted to the data needs of health services at all level including at the communities level can possibly help general improvement of health services management. The WHO has likewise accentuated that the absence of enhanced HMIS does not help in decision making process (Lippeveld, Sauerborn and Bodart, WHO, Geneva 2000).

The Healthcare Management Systems have potential significance, however despite this fact it is practically a major problem for third world countries in collection, compilation, analysis and utilization of healthcare information. Numerous nations have chosen to handle the issue of HMIS by tending to at its root, and arrangement for more coordinated methodology to enhance it. Nations like Cameroon, Tanzania, Pakistan, and Mozambique focused on routine Information System for primary care facilities (Lungo, 2003).

According to Rodrigues and Israel (1995) as cited by Lungo (2003), the drive for a change in HMIS has concurred with the data innovation since 1980s. WHO has additionally emphatically accentuated on the utilization of machine innovation in the outline of district-based health information system. However a considerable amount of countries which have computerized their HMIS are experiencing absence of properly trained staff and hardware and software Maintenance Problems (Campbell, 1997), (Hedberg 2003), (WHO 2004).

According to Braa et al (2003) as cited by Lungo (2003), the national health information systems in numerous developing nations have been unequivocally focused around the Primary Heath Care (PHC) administration. The district gets then the most fitting level for facilitating top-down and bottom up planning, for sorting out community involvement in planning, and execution, and for enhancing the coordination of government and private care. A broad participatory action examination began in South Africa which has additionally spread to different nations like Mozambique, Tanzania, and India. Health Information System Program (HISP) shows solid methodologies and address how to create district–based health information systems that is offered by open source software.

The contention is that local or provincial and district health managers and planners in the third world nations have not had the capacity to examine and translate such information for planning, and ought to be engaged through solid decentralization. Sandiford et al (1992) as cited by Lungo (2003), Computer-based data framework ought to be implemented to encourage better storage, investigation and dissemination of health information. However introducing computer technology in the improvement of health information system is not so much the silver-billet that tackles the efficiency issue of the health service.


Statement of the Problem

Regular issues in the utilization of IT incorporate absence of user-friendly hardware, poor framework support, and absence of sustainable energy source and deficiency of enough trained staff. Accordingly, it must be taken into consideration the primary thing in any case that the information entered must be precise; management must be equipped for controlling the computer system into meaningful data particularly when non-medicinal staff or low-level experts do the information gathering. In any case, the key issue to meaningful information lies in the faultless inputting of pertinent information and an institutionalized practical IT framework (Keen 1994). Under the technology of information administration; computers get vital to handle substantial volume of information or data in an organized and quick way for speed, quality, precession, clarity, consistency, dependability and proficiency. However, it cannot produce information rather it can just process it.

Despite the credible use of HMIS for evidence based decision making like strategic planning, enhanced patient care, proficient allotment of scarce assets and effective focusing of intervention to those in the greatest need heading for better result, however there is an enormous sympathy towards the improvement of the health care services delivery systems, which is generally seen to be attributed to the weaknesses of HMIS in the developing nations.


Scope of the research

The research will be based on Service Reporting System in the HMIS and is restricted to health facilities and management units at national health services.


Research Methodology

The research will involve choosing four primary care units from City of London. The questionnaire will be filled by all the individuals involved in the handling of HMIS. A questionnaire to be filled by the individuals who are directly involved in taking care of and utilizing HMIS at Primary health care centres, working for National Health Services (NHS). Individuals will complete the questionnaire and from these, the researcher will assess the current ongoing framework to determine strength and shortcomings, developing strategies and solutions to improve the flaws. Also analyzing the data on the latest version of Statistical Package for the Social Sciences (SPSS).


Significance of the research

Exploring the current HMIS situation in the area to recognize the qualities and weaknesses of the framework to address the problem areas. The concluding results of the research is relied upon to be useful and will input in improvement efforts of the HMIS and in the dissemination of learning picked up in the research.


References

Beaumont R ( ). Evaluating Health Information System, Introduction to Evaluating Health Information System.

Braa J (2003). Strategies for developing Health Information System in Developing Countries, South Africa.

Campbell, B B (1997). Health Management Information System in Lower Income Countries, Analysis of system design, implementation and utilization in Ghana and Nepal, WHO, New York.

Hiaasen D S and Striver D J (2004). A Framework for assessing HMIS in Developing Countries: Latvia as a case Study. (Proceedings of the 37th Hawaii International Conference on System Science).

Lippeveld T, Sauerborn R, Bodar C T (2000). Design and Implementation of Health Information Systems, WHO, Geneve.

Lungo J H, May 2003. Data Flows in Health Information Systems, University of Oslo, Department of Informatics, Norway.

O’Brien, J (1999). Management Information Systems – Managing Information Technology in the Internetworked Enterprise. Boston: Irwin McGraw-Hill.

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A Caring And Helping Profession Nursing Essay

As an associate degree practicing nurse, working on a cardiac unit, my scope of practice has been primarily focused on direct patient care. I have always been motivated to help my clients whenever possible to attain optimal level of restoration through different methods of therapeutic regimen and teaching. I assist my clients to meet their immediate needs, smiling, listening, using therapeutic touch where appropriate, and communicating effectively. I involve my clients and their families in their care by keeping them informed with medications, laboratory and diagnostic testing. I am a big advocate of the phrase ‘Knowledge gives power’ because it fosters nurse-client relationship and trust. I believe very much in engaging my clients with the knowledge of their disease process, the plan of care and the method of care delivery that will ensue. Knowing what to expect usually gives clients more control and they are more willing participants in an unfamiliar environment while coping with unfamiliar diagnosis and the challenges of being sick.

However, transitioning to a baccalaureate program now, I realize that my approach to nursing is evolving and becoming more dynamic and inclusive to promote a more holistic method of care delivery. Primarily based on the body of knowledge that is emerging on my journey back to school and prior experience, I have come to understand what the philosophy of nursing means.

Nursing philosophy forms the framework for nursing practice and guides the application of nursing process to effectively manage the complexities of evolving nursing roles. “Developing a nursing philosophy requires that a nurse embarks on a journey of self-discovery”, Rew, 1994. It starts by recognizing and understanding the ‘interconnectedness of all things,’ how human beings relate with their environment and how it affects their health. Based on the body of knowledge and experience, nurses usually have a set of beliefs, values and ideologies that influence perceptions, thoughts and feelings, (Hood. pg. 60). These values are usually etched within the framework of ethical principles and they constitute a nursing philosophy. The profession of nursing primarily deals with human beings, health, nursing and environment and as such nurses need to examine and reflect on what each of these concepts mean and how they are related to one another in order to affect each positively.

Human beings are unique, holistic individuals characterized by genetics and biologic compositions. Human beings are defined by their understanding, perception, reasoning, life experiences, spirituality and cultural background. Human beings have intrinsic values and have ‘inalienable rights’, and the right to be treated with dignity and respect from conception to death.

Health is a state of well-being. Health is defined as the optimal functioning of all physical, psychological, social, sensing, feeling and communicating systems. A state of total shalom, nothing missing, nothing broken. A state of health is viewed as a point existing on a continuum, from wellness to death and it varies with individual perception of what wellness is. As defined by World Health Organization, Health is a “State of complete, physical, mental and social well-being, not merely the absence of disease or infirmity.”

Nursing is a helping profession, a synergy of arts and science. The science of nursing is based on the principles and theories of behavioral and natural sciences, the embodiment of scientific knowledge, skills and professional values and morals instilled in practice and care delivery. Nursing encompasses the collaboration and autonomous care of all individuals in all settings, it includes health promotion, awareness, prevention of diseases and a restoration from deviation of health.

Environment is not limited to physical space, but characterized by intrinsic and extrinsic factors, that defines a person. Internal factors that affect mood and wellness are considered environment and external environment includes families, social, spiritual, cultural factors that affect a man. Sill & Hall view human beings as an “interrelated, interdependent, interacting complex, organism, constantly influencing and being influenced by the environment.” (Sills & Hall, 1977, p.24).

Bearing in mind that the profession of nursing is centered on these four metaparadigms: Human beings, health, nursing and environment, it is imperative for nurses to approach care delivery to human beings in a holistic manner factoring in the interrelatedness of how one affects the other.

Environment co-exists with human beings in a reciprocal relationship and as such affects individuals positively or negatively. It may be a disruptive or peaceful relationship. Deviation from a state of well-being is a disruptive state that requires the helping compassionate care of nurse professionals. As individuals are constantly adapting to varying degrees of changes in their internal and external environment, nursing is a piece of healthcare delivery system that constantly strive to assist individuals to attain their optimal level of wellness. Utilizing the nursing process and accessing multi-disciplinary approach in a holistic goal directed manner, nurses assume multiple roles of professional caregivers, teachers, advocates and counselors to accomplish competent and compassionate care in different continuum of an individual state of health.

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The theoretical models and frameworks of various nurse theorists has emerged as a guide to nursing philosophy and care. They provide a body of knowledge used to support nursing practice. They each define their nursing philosophies placing human beings as the center of care but cognizant of the interconnectedness and relationship of health, environment and nursing interacting and affecting each other. Sister Callister Roy Adaptation model is one that has impressed on my heart and has influenced my practice.

Sister Callister Roy is a nurse theorist, professor and author, compelled by instructor, Dorothy Johnson, to write a conceptual model of nursing while studying for her Master’s degree at UCLA She proposed ‘The Roy Adaptation Model’ theory (RAM). Studying through this theory gives me a better understanding of man’s adaptive capacity in response to stimuli and also the intrinsic nature of man to adapt various modes to cope with life challenges especially relating to health.

In this mode, Human being is viewed as a holistic adaptive creature capable of adaptive systems. She describes the Environment consisting of internal and external stimuli that interacts directly with human beings. She sees Health as a sound unimpaired condition leading to wholeness and the Nursing goal as that which promotes modes of adaptation and that support overall health.

The four Modes of adaption of RAM promote integrity and they are: the physiologic-physical mode, the self-concept- identity mode, role function and interdependent mode.

Physiologic-Physical Mode identifies the intrinsic factors comprised of physical and chemical processes that occur in human beings that are responsible for the functions and activities of daily living. The underlying need is physiologic integrity evidenced in the degree of wholeness achieved through adaptation to change in needs.

Self-concept-Identity Mode focuses on the psychological and spiritual integrity and the sense of unity as humans search for the meaning and purpose of life

Role Function Mode deals with the individual roles that we occupy in society and how we aim to fulfill the need for social integrity. The knowledge of knowing oneself in relation to others.

Interdependent Mode looks at the interconnectedness and relationship of people, environment, structure and perception. Adaptation potentials individually and collectively.

Using RAM’s six- step nursing process, the nurse gathers a full assessment of a client including behavior, orientation, family dynamics, objective and subjective data. The second step is to recognize and determine the stimuli affecting the behaviors exhibited. The third step involves formulating a nursing diagnosis based on the presenting symptoms and the person’s adaptive state. The forth step is goal oriented and nursing planning to promote adaption and wellness which leads to the fifth step of nursing interventions. Utilizing several methods of therapeutic healing tailored to each individual crisis state with the ultimate goal of managing the stimuli to promote adaptation. The final and sixth step is the evaluation stage, using reflection and data to reassess the individual state of adaptation mode or lack of it. The ability of the nurse to manipulate the stimuli and not the patient enhances the person’s interaction with their environment, gives them a sense of control and promote health.

Nursing, as stated earlier, is a synergy of science and art. Nursing is a learned profession and as such nurses are required to have a formal education, clinical practice and research in order to understand the biologic, physiologic, behavioral and social sciences to make decisions. The application of that body of knowledge in practice is built on the art of nursing. Delivery of care with wisdom, compassion, genuineness, empathy, respect for dignity and a sound commitment to do good at all times is the basis of the art of nursing.

Nursing is an experience that occurs between two individuals forming the nurse-patient interaction. Nursing is constructed around the centrality of nurse-client relationship and how they affect each other positively. When nurses use knowledge and personality to implement interventions in the nursing process to effect change in the ill, they alleviate stress and the relationship becomes therapeutic. It is through the establishment of therapeutic association that nurses are said to promote healing (Allen, 2000: 184).

In the early days, Nursing derived knowledge through intuition, tradition and experience or by borrowing from other disciplines (Kalisch &Kalisch, 2004). The knowledge of nursing has since then shifted to empirical knowledge discovered through research. Research is vital in nursing today because it expands nursing knowledge and integrates best evidence based practice into clinical practice. The systemic review of literature aspect of research makes it possible for quality improvement activities and to determine the effectiveness of nursing interventions and practice changes. Research allows clinical practice to evolve in knowledge and it gives confidence in practice based on satisfactory patient outcomes.

http://en.wikipedia.org/wiki/Callista_Roy

http://tgh.org/nursing.htm

http://coxcollege.edu/cc_body.cfm?id=3062

Therapeutic Nursing: Improving Patient Care through Self-Awareness and reflection … SAGE, Nov 4, 2002 –

edited by Dawn Freshwater v

http://svnnet.org/uploads/File/NurseResearch.pdf

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Carotid Artery Stenosis: Surgery or Stent


Case Presentation

Mr. AS is a 68 y/o AAM who presents to his primary care physician (PCP) for his annual routine checkup. He has a past medical history (PMH) of HTN, HLD, and a 50-pack year of tobacco smoking. He drinks a couple of times a week, especially when he “plays poker with the fellas”, and an unrestricted diet. During his exam his PCP detects a moderate to severe bruit on the left side. Mr. AS’ physician is concerned and decides to send him for a carotid ultrasound (U/S) right then and asks him to return to clinic once the U/S is complete.

The ultrasound done in the outpatient clinic revealed a 60% stenosis at the bifurcation of the left internal/external carotid artery. An appointment was scheduled for the following day at the vascular surgeon’s office to assess the need for intervention and revascularization. At the appointment the vascular surgeon also detects a bruit on auscultation. The patient denies any history of focal neurologic symptoms but does admit to some lightheadedness and dizziness on occasion that he attributes to “just getting older”. The vascular surgeon prefers his own in-office sonographer and therefore, repeats the carotid U/S, which more accurately reveals an 80% stenotic lesion of the left carotid artery.


Introduction

Carotid artery stenosis is one of the most common causes of ischemic stroke (CVA) and transient ischemic attacks (TIA).1 The incidence of stroke becomes considerably increased with the extent of artery stenosis.1 Over the last 10 years there have been many significant improvements in how we care for patients with internal carotid artery (ICA) stenosis.1-3 The improvements seen in pharmacologic agents cannot be understated, especially when it comes to the management of high cholesterol, hypertension, and diabetes. These newer drugs have made terrific strides towards the risk reduction of stroke in patients with both symptomatic and asymptomatic carotid disease.  Next, there have been clinical trials that have compared carotid endarterectomy (CEA) to carotid artery stenting (CAS) amongst patients with symptomatic and asymptomatic disease.4-6

In addition to assessing the degree of stenosis, a good history and physical is crucial when deciding how to manage the patient with carotid disease. A good history and physical can help guide a clinician’s decision making on surgical management, or conservative treatment with other options. Ischemic strokes account for more than 80% of all strokes and roughly 20% of those are due to stenotic carotid arteries.1 While recent advances in pharmacologic management has helped to reduce the number of patients developing carotid stenosis, in the U.S. population, obesity remains on the rise and, unfortunately, despite public health warnings, many Americans continue to smoke.7 Both of which remain significant contributors to systemic vascular disease, not the least of which is carotid artery stenosis.1

The approach to carotid disease is largely based on symptoms and degree of stenosis. There are generally three possible scenarios to evaluate. Patients that are asymptomatic, yet, have an 80% or greater stenosis should be revascularized as soon as possible to prevent stroke.7 In patients that have completed a stroke, the approach is a little different, in that revascularization should be done within a two-week period following the initial event.1 During the two-week window, optimal medical therapy should be initiated.1,7 Thirdly, the patient that is actively having a TIA needs to be taken to the operating room urgently to revascularize the stenosis, with the goal of preventing an all-out stroke.1 The approach to these three potentially different clinical presentations are based on recommendations from the landmark CEA trials published in the mid 1990’s (NASCET, ECST, ACAS, ACST).1,7


Diagnostic Tools

Carotid artery stenosis can be diagnosed using several options. As it is non-invasive and lacks radiation exposure, duplex ultrasound (U/S) is currently the screening test of choice. Other options include CT angiography (CTA) and magnetic resonance angiography (MRA).3 CT exposes the patient to high-dose radiation and CT and MRA are very time consuming and costly. Also, to note, CTA will often times underestimate the degree of stenosis, while MRA will overestimate the degree of artery occlusion. CTA and MRA are usually only used in highly selective patients with lesions high in the neck, referred to as “high lesions”, where advanced imaging techniques would yield information the surgeon felt would be particularly helpful intraoperatively. Since most carotid lesions arise at the bifurcation of the internal and external carotid, the use of CTA and MRA are used less frequently by experienced vascular surgeons that perform frequent endarterectomies.


Symptomatic Carotid Stenosis

In patients with symptomatic carotid artery stenosis, the risk of stroke, recurrent stroke, or TIA can be minimized with revascularization of the internal carotid artery.1,8 The big question at this point becomes whether your patient is a better candidate for surgical intervention via CEA or the less invasive, CAS. With either of these choices, the clinician should always implement intensive pharmacologic therapy.1,9 To date, CEA remains the superior choice for carotid revascularization among asymptomatic and symptomatic patients that meet certain ultrasound criteria.7,10 Below is a list of ultrasound flow velocities that are used in vascular surgery to determine the degree of stenosis that is present in patients.11 These criteria are used to help guide decision making for revascularization.  If the patient is asymptomatic but has a lesion that is stenotic 80% or greater, revascularization is indicated and should be considered.8 If the patient has a stenotic lesion of greater than 70%, and is asymptomatic, revascularization is then considered.8

Velocity grading criteria based on the NASCET angiographic method11

Data that was published from the carotid revascularization endarterectomy versus stenting trial (CREST) indicated that CEA was superior to CAS.4 However, in a recently published 10-year follow-up to the CREST trial, new data have been published.5 The new data from the follow-up reveals that CEA was superior to CAS in the periprocedural period, resulting in fewer strokes.5 Nonetheless, once patients made it past the periprocedural timeframe, CEA and CAS were shown to be equal in terms of long-term treatments that can be employed for preventing an ischemic stroke in patients with symptomatic carotid stenosis.5

In terms of timing, the best possible time to revascularize a patient that is symptomatic is within two weeks of the inciting event.1 If it is decided between the patient and care team to wait past this two-week window, the overall benefits of revascularization have a sharp falloff.1 During the time period immediately following the CVA or TIA, at which revascularization can occur, patients should be started on intensive medical therapy.1,2 The recommended regimen for intensive medical therapy for these patients includes a high-intensity statin with a target LDL of < 70mg/dl, dual antiplatelet therapy agents, blood pressure (BP) regulation to maintain a systolic BP of < 140mmHg or < 130mmHg if diabetic, and a hemoglobin A1C < 7%.1,2,6 Other helpful therapies include lifestyle modifications that consists of smoking cessation, moderate exercise, and a goal to reduce their weight to ideal body weight.1


Carotid Artery Stenting

While CEA is currently the gold standard for revascularization of carotid stenosis, CAS is a second plausible option for patients.2,3 CAS materials and the technology to safely deploy them have improved significantly in the last decade.3 In addition to being an alternative to CEA for patients that are at risk for having surgery, CAS remains an option for those with advanced age, aberrant anatomy, or patients that have had radiation exposure to their neck.1,7 One potential concern with CAS is the periprocedural risk of stoke that exists. Therefore, the risk-benefit options should be discussed at length with the patient who is considering CAS.

As stent technology has been rapidly evolving, few stents have yet to deliver results superior to CEA. Though, in 2018 a study was published in Austria with very encouraging results.3 The study looked at a new stent design called the Casper Stent System, that was used in 138 patients.3 This double layered stent which demonstrated supreme vessel conformity, was deployed successfully without any technological failures or adverse neurological events within a ninety-day period, post stent placement.3 The main purpose of this new stent design is to lower or avoid altogether, the periprocedural stroke risks which were seen in the CREST trial as well as the ten-year follow-up from the CREST trial.3,4,12 The investigators from the Casper Stent System study suggest that the reduction in stroke and embolic events seen with their stent, are possibly as a result of its one of a kind dual layer design.3

 


Conclusion

The patient that was included in the introductory case presentation of this paper, despite being asymptomatic, did have a greater than 80% occlusion of the left internal carotid artery (ICA). He was taken to the operating room the day following his office visit and a CEA was successfully performed. Left, is a picture of the atheroma that was removed. Postoperatively he was admitted to the ICU where he developed some hypertensive issues requiring a continuous IV Nicardipine drip to help maintain an acceptable blood pressure. He didn’t experience any postoperative bleeding, neurological symptoms, or swelling.

Most patients that are seen on the vascular surgery service can be adequately assessed for the need of carotid revascularization based on the degree of stenosis and whether or not they are experiencing symptoms or remain asymptomatic. Currently the method of choice for carotid revascularization remains CEA.1 However, in select high-risk patients with special anatomic considerations such as a “hostile neck” secondary to trauma, past surgery, or radiation, it is reasonable to consider pharmacologic or CAS therapy.1,9 Fortunately, CEA comes with a very low (<1%) risk of intraoperative or postoperative stroke if done by an experienced vascular surgeon, and offers the patient a significant risk reduction of experiencing stroke or TIA in the future.

Lastly, while the use of balloon angioplasty and stenting for coronary artery disease has been very successful, the use of stents in carotid disease has yet to prove superior to CEA in randomized controlled studies.6,8,9 CAS has emerging promise for those suffering from carotid disease in the not too distant future.3 As stent design evolves and pharmacologic protection of against embolus formation improves, CAS may be the way of the future for many vascular surgery services.2,3 The results of the CREST-2 Trial that are expected in 2020, will be interesting to see and will likely help reshape how we approach various aspects of carotid disease treatment.7 Stay tuned!


References:

1. Vavra AK, Eskandari MK. Treatment options for symptomatic carotid stenosis: timing and approach.

Surgeon.

2015;13(1):44-51.

2. Noiphithak R, Liengudom A. Recent Update on Carotid Endarterectomy versus Carotid Artery Stenting.

Cerebrovasc Dis.

2017;43(1-2):68-75.

3. Mutzenbach SJ, Millesi K, Roesler C, et al. The Casper Stent System for carotid artery stenosis.

J Neurointerv Surg.

2018;10(9):869-873.

4. Brott TG, Hobson RW, 2nd, Howard G, et al. Stenting versus endarterectomy for treatment of carotid-artery stenosis.

N Engl J Med.

2010;363(1):11-23.

5. Brott TG, Howard G, Roubin GS, et al. Long-Term Results of Stenting versus Endarterectomy for Carotid-Artery Stenosis.

N Engl J Med.

2016;374(11):1021-1031.

6. Howard VJ, Meschia JF, Lal BK, et al. Carotid revascularization and medical management for asymptomatic carotid stenosis: Protocol of the CREST-2 clinical trials.

Int J Stroke.

2017;12(7):770-778.

7. Safian RD. Asymptomatic Carotid Artery Stenosis: Revascularization.

Prog Cardiovasc Dis.

2017;59(6):591-600.

8. Yu C, Han X, Zhang XL, Yu B, Dong Q. Long-term effects of white matter changes on the risk of stroke recurrence after carotid artery stenting in patients with symptomatic carotid artery stenosis.

J Neurol Sci.

2016;369:11-14.

9. Cremonesi A, Castriota F, Secco GG, Macdonald S, Roffi M. Carotid artery stenting: an update.

Eur Heart J.

2015;36(1):13-21.

10. Kakkos SK, Kakisis I, Tsolakis IA, Geroulakos G. Endarterectomy achieves lower stroke and death rates compared with stenting in patients with asymptomatic carotid stenosis.

J Vasc Surg.

2017;66(2):607-617.

11. Simpson RJ, Akwei S, Hosseini AA, MacSweeney ST, Auer DP, Altaf N. MR imaging-detected carotid plaque hemorrhage is stable for 2 years and a marker for stenosis progression.

AJNR Am J Neuroradiol.

2015;36(6):1171-1175.

12. Gurm HS, Yadav JS, Fayad P, et al. Long-term results of carotid stenting versus endarterectomy in high-risk patients.

N Engl J Med.

2008;358(15):1572-1579.

 

Assignment: PICO analysis

Assignment: PICO analysis

Assignment: PICO analysis

A PICO analysis is used to pose a focused clinical question to which you find appropriate evidence-based answers. The PICO question should include the patient or population (P), anticipated intervention (I), comparison group or current standard (C), and outcome desired (O). In this Assignment, you develop a question related to dementia, delirium, or depression. Through your PICO analysis, you explore various resources and examine current evidence to answer the question you develop.


To prepare:

  • Select one of the following disorders as your topic: dementia, delirium, or depression.
  • Review the guidelines in the “Literature Review Matrix” document in this week’s Learning Resources.
  • Think about a research question around your issue as indicated in Part I: PICO Analysis of Research Topic.
  • Consider the resources you will use, search terms and criteria, and Boolean search strings as indicated in Part II: Search Strategy.
  • Using the Walden Library and other appropriate databases, locate five articles related to your PICO question. At least one article must be a systematic review. All of the articles should be primary sources.
  • Reflect on the five articles you selected as indicated in Part III: Analysis of Literature. Consider the conceptual framework/theory, main finding, research method, strengths of study, weaknesses, and level of evidence for each article.
  • Consider how to use the summaries in Part III to create an evidence table. Use this evidence table to determine appropriate treatment options for patients who present with the disorder you selected as your topic.


To complete:

  • Formulate a question around the disorder you selected as indicated in Part I: PICO Analysis of Research Topic.
  • Identify the resources you will use, search terms and criteria, and Boolean search strings as indicated in Part II: Search Strategy.
  • Summarize the five articles you selected as indicated in Part III: Analysis of Literature. Describe the conceptual framework/theory, main finding, research method, strengths of study, weaknesses, and level of evidence for each article.
  • Create an evidence table based on the article summaries in Part III. Describe appropriate treatment options for patients based on this evidence table.




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You must proofread your paper. But do not strictly rely on your computer’s spell-checker and grammar-checker; failure to do so indicates a lack of effort on your part and you can expect your grade to suffer accordingly. Papers with numerous misspelled words and grammatical mistakes will be penalized. Read over your paper – in silence and then aloud – before handing it in and make corrections as necessary. Often it is advantageous to have a friend proofread your paper for obvious errors. Handwritten corrections are preferable to uncorrected mistakes.


Use a standard 10 to 12 point (10 to 12 characters per inch) typeface. Smaller or compressed type and papers with small margins or single-spacing are hard to read. It is better to let your essay run over the recommended number of pages than to try to compress it into fewer pages.


Likewise, large type, large margins, large indentations, triple-spacing, increased leading (space between lines), increased kerning (space between letters), and any other such attempts at “padding” to increase the length of a paper are unacceptable, wasteful of trees, and will not fool your professor.


The paper must be neatly formatted, double-spaced with a one-inch margin on the top, bottom, and sides of each page. When submitting hard copy, be sure to use white paper and print out using dark ink. If it is hard to read your essay, it will also be hard to follow your argument. Assignment: PICO analysis