A healthy heart

abstract

A healthy heart is the key to good life .The heart is a vital organ of the human body which ensures the effective pumping of blood throughout the circulatory system. Due to our sedentary lives and food habits, the heart is prone to malfunctioning, and heart attack (i.e. coronary artery disease), is one of the primary cause of death [1]. Heart attack is caused by a blockage of the coronary arteries, typically at a site of narrowing (stenosis) caused by atherosclerosis. It is difficult to accurately determine the degree of atherosclerosis in arteries, particularly in the early stages of disease. One method that has been introduced is the intravascular ultrasonic catheter (IVUS), which sends a pulse of sound from a receiver and uses the returned echo to deduce the properties of the arterial tissues.

Doppler Ultrasound is a similar a diagnostic, noninvasive technique which can effectively evaluate the blood flow velocity in the coronary arteries by passing the high frequency ultrasound waves into the blood using a single receiver. Our group has found that an improvement in velocity estimation can be obtained if the returned Doppler ultrasound echo is collected by multiple receivers and the information from those receivers is combined. The research proposed here will use simulation methods to determine the extent to which this same concept can be applied to multiple IVUS receivers.

1. introduction

Doppler ultrasound provides a measure of the velocity distribution of blood throughout the volume of the artery. Because the signal is a superposition of echoes from multiple scatterers, the red blood cells, distributed in space, the signal at the receiver is subject to constructive and destructive interference. This phenomenon is called “coherent scattering” and is the primary reason that Doppler ultrasound signals are inherently noisy. The same phenomenon applies to ultrasonic imaging (B-mode imaging), in which the Doppler shift is ignored and only the magnitude of the returned signal is used to form an image of the tissue. However, in B-mode ultrasound, the scatterers are variations in the acoustic impedance of the tissue. Figure 1 shows a typical IVUS image [6]. Whereas it is possible to differentiate between the lumen, media and adventitia, the exact boundaries are difficult to determine as a result of the coherent scattering effects.

2. background

2.1. Principles of Ultrasonic B-Mode Imaging

B mode imaging is typically used for ultrasound imaging as it facilitates the display of the echoes at various brightness or gray levels corresponding to their amplitude.[ee handbook]

Most B-mode systems in use today

create an image in 0.1 s or less, so that the image is displayed in real-time for viewing of moving structures,

such as structures in the heart or the fetus moving within the womb. This is not possible with the typical

magnetic resonance or computed tomography system.

Most of these systems use the Doppler principle, but some use time domain detection. In Doppler detection,

if the ultrasound is reflected from a target moving at some speed vt toward (away from) the source at an angle

q with respect to the beam axis, the frequency of the transmitted signal f is shifted up (down) by an amount

fD, the Doppler shift, according to the following relation:

(116.4)

In principle a measurement of fD, when f, c, and q are known, will yield the speed of the target vt. However, it

is often difficult to determine q because the angle the transducer axis makes with a blood vessel, for example,

is often unknown. Even when that angle is known, the flow is not necessarily along the direction of the vessel

at every location and for all times

Two-dimensional B-mode display: Echoes from a transducer, or beam, scanned in one plane displayed as

brightness (or gray scale) versus location for the returned echo to produce a two-dimensional image. Duplex ultrasound: Simultaneous display of speed versus time for a chosen region and the two-dimensional

B-mode image. B-mode display: Returned ultrasound echoes displayed as brightness or gray scale levels corresponding to

the amplitude versus depth into the body

fig 6 in devts in cardio vascular ultrasound.pdf—describes input signal used………………………

B -mode (Brightness mode) ultrasound is the most commonly applied ultrasound technique for intracoronary artery visualization. B-mode images are made up of one dimensional signals from transducer crystals aligned in an arrays,which can also be displayed in two dimensional in the form of a sector[August et al].In This mode of imaging, depth and the brightness are the measure of radial axis and echo intensity.

2.1.1. Scattering of sound

echo description fundamental sources of errors

2.1.2. Relationship between sound intensity and scattering coefficient

The size of the scattering shadow is called the effective cross-section (s [cm2]) and can be smaller or larger than the geometrical size of the scattering particle (A [cm2]), related by the proportionality constant called the scattering efficiency Qs [dimensionless]:

The scattering coefficient µs [cm-1] describes a medium containing many scattering particles at a concentration described as a volume density s [cm3]. The scattering coefficient is essentially the cross-sectional area per unit volume of medium.

Scattering coefficient: The factor that expresses the attenuation caused by scattering, e.g., of radiant or acoustic energy, during its passage through a medium. Note: The scattering coefficient is usually expressed in units of reciprocal distance. Attenuation: The decrease in intensity of a signal, beam, or wave as a result of absorption of energy and of scattering out of the path to the detector, but not including the reduction due to geometric spreading. [After JP1] Note 1: Attenuation is usually expressed in dB. Note 2: “Attenuation” is often used as a misnomer for “attenuation coefficient,” which is expressed in dB per kilometer. Note 3: A distinction must be made as to whether the attenuation is that of signal power

Measurement of the intensity distribution of laser radiation using…

by VV Morozov – 1979 – Related articles – All 4 versions

of interaction between the light and sound, i.e., in which the scattering coefficient would depend linearly on the sound intensity. …

2.1.3. Constructive and destructive interference

Sound travels in the form of waves.These waves are associated with frequency and amplitude.From basic laws of physics it is known that intensity is directly proportional to amplitude of the wave which is the discriminating factor between different modes of ultrasound imaging.When these sound waves interact with each other interference occurs.The type of interference is determined by measuring the amplitude of the resultant wave formed by interaction of 2 sound waves.If the amplitude of 2 waves is either positive or negative then the resultant wave has larger amplitude.This phenomenon is known as constructive interference(or in phase interference).

If the interacting waves have opposite amplitude then the resultant wave has a lower amplitude.This phenomenon is known as destructive interference(or out of phase interference). The interference type depends on the difference in distances that each wave has to take.

In this context,if the ultrasonic signals are emitted from a single transmitter and captured from multiple receivers separated by a distance of half the wavelength, then we can observe constructive interference of returned echo amplitudes of the scaterrers locate d in region of interest at one receiver and destructive interference occurring at the second receiver located half the wavelength apart.[cite reference wu thesis book].

2.1.4. Signal processing for B-Mode images (e.g. envelope detection)

Intracoronary ultrasonic is done on envelope detection of the sum of (returned) echo signals from each receiver .there are many/three ways of envelope detection. One simpler method of doing it is to perform a full wave rectification on the returned echo followed by a low pass filtering to remove the side lobes of the signal. [rectify/demodulate the signal and process it by passing it through a low pass filter to remove the side lobes of the returned echo].though this method of envelope detection appears to be simpler, the operating center frequency for each of the returned signal is to be known and possibly tracked from time to time for changes. The second/another yet complex method of envelope detection is using Hilbert transform to get /generate/create a rational /methodical representation of the returned signal from each scatterer at each receiver. The advantage of using this method is that it is independent of the dampening effect present in the returned signal. (i.e. the changes in center frequency of the echo with time).The magnitude obtained from the complex signal is used as the final signal for ultrasonic imaging/next stage of converting into polar plots and plotting it using weighted average method . (refr:sprab12 page 11 and B-mode handbook).quadrature detection can also be used for extracting the envelope of the signal.refrce(high resolution ultrasound)

2.2. Current implementations of intracoronary imaging

Heart disease can be diagnosed with the aid of Doppler and B-mode ultrasound, where the Doppler method provides a measure of flow rate and B-mode ultrasound provides an image. Generally these techniques, as typically used, do not have the spatial resolution to examine flow in the coronary arteries. Coronary artery geometry is diagnosed by injecting a radio-opaque dye into the artery with a catheter and taking x-ray images. However, this method does not specifically provide the locations of atherosclerotic lesions. It provides the internal geometry of the arterial lumen. Intracoronary Doppler ultrasound is a method in which a Doppler-tipped catheter is inserted into the coronary artery to measure blood velocity. IVUS uses a more complicated catheter that has an array of ultrasound crystals arranged in a ring at the tip of the catheter, and each crystal transmits an ultrasound pulse radially and then receives the returned echo. With multiple crystals, a 2-dimensional image of the cross-section of the arterial lumen can be reconstructed. This technique is currently capable of providing real time cross sectional images in vivo [3].

The main objective of Doppler ultrasound is to extract “the flow velocity measurements and interpret them in physiologically significant variables “through assumptions and velocity calculations [2]. The most fundamental quantity we consider is the flow rate as it best describes the extent of perfusion of blood in the region of interest [2] (i.e. a section of the coronary artery). The objective of IVUS is to obtain a mapping of the make-up of the artery as an image. Although IVUS uses several transmitter-receivers, only a single receiver is being used to capture the reflected ultrasound wave and to view the circumferential view of the artery.

The problem involved by using a single receiver is that we miss many precise details about the physiological status of the artery due to its limited view and the obtained images are noisy because of coherent scattering. The possible solution can be to use multiple receivers to look at the region of interest from different angles to get a detailed view. The doctor can get a clear picture of the artery in terms of velocity, flow rate, the size of plaque present inside artery and can treat the patient in a better way.

2.2.5. Geometry of the transducers.

We assume transducer as a point size spherical shaped piezoelectric crystal.

Papers: B-mode handbook.pdf

sprab12.pdf page 7

2.2.6. Transducer frequency response characteristics.

The phrase frequency response characteristic usually implies a complete description of a system’s sinusoidal steady-state behavior as a function of frequency.

2.2.7. Specifics of the transmitted signal

from program

2.2.8. Signal conditioning and signal processing

2.3. Limitations of intracoronary imaging (particularly coherent scattering/scattering from multiple scatterers)

One of the main problems encountered with Doppler and B-Mode ultrasound velocity estimation is coherent scattering of noise. Coherent scattering error is caused by the changes in phase of the reflected echo as the red blood cells enter and leave the sample volume. “This phase depends on the distance of the transmitter to the scatterer and then to the receiver” [5]. The main research objective is to simulate this process of multiple receiver Doppler ultrasound using Matlab simulation software and to see how well it improves the understanding of image quality and clarity. Even the state of art of image is to be observed using the simulations.

paper : basic model of ivus.pdf page 8

Intravascular ultrasonic image quality remains poor due to speckle noise, imaging artifacts and shadowing of parts of vessel wall by calcifications. (Refce: intravascular ultrasound image segmentation.)

2.4. Previous work done on multiple receivers – independence of coherent scattering noise in Doppler signals when receivers are sufficiently far apart.

Velocity Measurements made/obtained over the region of interest (ROI) in an intracoronary artery have inherited velocity estimation errors due to coherent scattering. One of the methods to reduce these estimated errors is the use of multiple receivers .The echo received from each of the receivers will have some complementary information which not only improves velocity estimation, also contributes in enhancing the image clarity in a B-mode ultrasound image processing. [Jones, Krishnamurthy 2002] Improvement in velocity estimation is observed if returned Doppler ultrasound echo is collected and combined from all the multiple receivers. Most importantly the returned echo signal obtained at each receiver is independent of coherent scattering noise in Doppler signals when receivers are sufficiently far apart. In the case of an intracoronary artery, the RBC’s are the major kind of multiple scatterers distributed in artery space. Since the returned echo signal detected/obtained at each of the receiver is a summation of all the echo amplitude signals from multiple scatterers in the region of interest, they are subjected to constructive and destructive interference This way multiple receivers in B-mode can improve the image quality of B -mode intravascular ultrasound (IVUS) images.

Initially a 2 dimensional geometry for the artery would be simulated. The transmitted signal would be generated using by a piezoelectric crystal in an ultrasound in real time applications. But in this proposed research, using Matlab, we first try generating a discrete signal using the pulse generator. Based on the defined parameters such as the frequency, pulse width, amplitude, pulse repetition time, artery geometry[r (?)], angle of transmission of the transmitted and received signal, the image would be extracted. Primarily, the signal from a single scatterer is modeled. In the advanced stages, multiple scatterer signals would be modeled. The following questions would be answered while doing the actual simulation.

Each scatterer is modeled as a point source that reflects the transmitted signal with a set reflectivity. The scatterer does not alter the signal’s phase, but alters the amount of power that is returned to the receiver. Each receiver therefore is subjected to a signal that is the sum of returns from all of the scatterers, where it is important to keep track of the phases of the signals from each scatterer so that coherent scattering is adequately accounted for.

The signal at each receiver is rectified and then averaged in time with a moving window to produce a signal that represents scattered power as a function of time. The range, corresponding to the location in the image, is proportional to the delay time of the returned signal.

Each receiver will provide an image, and a composite image will be produced as the average over all of the receivers.

3.4.1. Transmitter/Receiver characteristics (transmitted frequency, beam width)

3.4.2. Speed of sound

3.4.3. Scattering coefficients for (1) Background and (2) Plaques

The fraction of the incident energy reflected or scattered is very small for soft tissues like elastin collagen etc. [ee handbook] The differential Backscattering coefficient/scattering coefficient is the aspect that expresses the attenuation caused by scattering, of acoustic energy, while passing through a medium. The scattering coefficient (µs) is usually expressed in units of reciprocal distance. There certainly lies a difference between the normal aortic intima and various kinds of atherosclerotic plaques. More than 90% of normal vessels usually have scattering coefficients in the range of 15 mm-1 to 36 mm-1 ,where as atherosclerotic plaques like the lipid rich blocks, fibrocalcific plaques have scattering coefficients lesser than 20 mm-1 [Levitz, Andersen et al ].The fibrous plaques which constituted elasin ,lipids and collagen demonstrated a relatively large variations in terms of scattering coefficient. Out of the three kinds of atherosclerotic plaques, fibrocalcific samples do not show up as sharp regions in any kind of image and hence can be assumed as in homogeneities within the tissue wall having highly scattering coefficient.

3.4.4. Random numbers (particle location and scattering coefficients)

3.5. Signal Analysis (envelope detection)

http://www.mathworks.com/products/demos/shipping/dspblks/dspenvdet.html

Hilbert Transform can be used to generate a time domain envelope. The point is to create a “rectified” signal that is more suitable for calculating a smooth envelope. In the frequency domain, magnitude data is already all positive, so I don’t know why you’d use Hilbert Transform. To get a spectrum envelope, just average several spectrum frames together. The key then is to choose correct frame size prior to FFT, which should be based on the nature of your data and the sampling rate you are using. Averaging will help your SNR and maybe you can differentiate key frequencies between good and damaged bearings. x = Hilbert (xr) returns a complex helical sequence, sometimes called the analytic signal, from a real data sequence. The analytic signal x = xr + i*xi has a real part, xr, which is the original data, and an imaginary part, xi, which contains the Hilbert transform. The imaginary part is a version of the original real sequence with a 90° phase shift. Sines are therefore transformed to cosines and vice versa. The Hilbert transformed series has the same amplitude and frequency content as the original real data and includes phase information that depends on the phase of the original data. If xr is a matrix, x = Hilbert (xr) operates column wise on the matrix, finding the Hilbert transform of each column. x = Hilbert (xr, n) uses an n point FFT to compute the Hilbert transform. The input data xr is zero-padded or truncated to length n, as appropriate. The Hilbert transform is useful in calculating instantaneous attributes of a time series, especially the amplitude and frequency. The instantaneous amplitude is the amplitude of the complex Hilbert transform; the instantaneous frequency is the time rate of change of the instantaneous phase angle. For a pure sinusoid, the instantaneous amplitude and frequency are constant. The instantaneous phase, however, is a saw tooth, reflecting the way in which the local phase angle varies linearly over a single cycle. For mixtures of sinusoids, the attributes are short term, or local, averages spanning no more than two or three points. Reference [1] describes the Kolmogorov method for minimum phase reconstruction, which involves taking the Hilbert transform of the logarithm of the spectral density of a time series. The toolbox function rceps performs this reconstruction. For a discrete-time analytic signal x, the last half of fft(x) is zero, and the first (DC) and center (Nyquist) elements of fft(x) are purely real. http://dip.sun.ac.za/~weideman/research/mfiles/hilb1.m

function h = hilb1(F, N, b, y)% The function h = hilb1(F, N, b, y) computes the Hilbert transform% of a function F(x) defined on the real line, at specified% values of y (y could be a scalar, vector, or matrix.)

8. bibliography

  1. http://www.johnshopkinshealthalerts.com/white_papers/heart_health_ch_wp/digital08_landing.html, last accessed on 02/26/2008, 08:30 pm.
  2. Jones SA, “Fundamental Sources of error and spectral broadening in Doppler ultrasound signals”, Crc critical reviews in Biomedical Engineering, page(s):399-483, 1993.
  3. Van der Steen AFW, Cespedes EI, de Korte C.L, Carlier S.G , Li W, Mastik F, Lancke C.T, Borsboom J, Lupotti F, Krams R, Sermys P.W, Bom N,”Novel developments in intravascular imaging”, Ultrasonics Symposium Proceedings, IEEE, Volume 2, page(s):1733 – 1742, 1998.
  4. Kumar P and Shoukri MM,” Copula based prediction models: an application to an aortic regurgitation study,” BMC Medical Research Methodology, page 7:21, 2007.
  5. Jones SA and Krishnamurthy K,”Reduction of coherent scattering noise with multiple receiver doppler”, Ultrasound in Med. & Biol., Volume 28, page(s): 647-653, 2002.
  6. Zhu H, Oakeson K D, and Friedman M H,” Retrieval of Cardiac Phase from IVUS IVUS Sequences”, Medical Imaging 2003: Ultrasonic Imaging andSignal Processing, Volume 5035, 2003 page(s): 1605-7422.

Ethical Decision Making in Smoking Cessation

According to University of California, School of Medicine (2010), Autonomy is the “personal rule of the self that is free from both controlling interferences by others and from personal limitations that prevent meaningful choice.”  Although Mrs. Cheng is a cancer patient with only one month to live, nowhere is mentioned that she could be of unsound mind or suicidal as certified by a doctor so her decision to smoke is then make while in a state of sound mind. Principle of autonomy states that patients are to be allowed to make their own decision without influence or coercion by another. Clearly Mrs. Cheng’s decision was to not to give up smoking. By asking Mrs. Cheng to decide not to go to the garden to smoke because of manpower constraint or any other reason which is not of patient’s own is a violation of her autonomy which is definitely not ethical.

According to Beauchamp (2008), Beneficence is a “moral obligation to act for the benefit of others, helping them to further their important and legitimate interests, often by preventing or removing possible harms”. Smoking is generally bad for health, and more so for people who already have cancer. Smoking is known to increase the size and extent of cancerous cells and metastases. (Zow, Hsu, and Eng, 2004). Thus the nursing staff should advise and encourage Mrs. Cheng to stop or reduce the number of cigarette she smoke as it will worsen her condition by possibly hastening death.

Non-maleficence is defined as not to deliberately cause unnecessary harm or injury to the patient, either through acts of commission or omission, “above all, do no harm” (McCormick, 2008). By restricting Mrs. Cheng to go out to smoke, the nursing staffs are depriving Mrs. Cheng of possibly the only thing that she enjoyed in what thought to be the last one month of her life thus affecting the quality of life Mrs. Cheng has. Mrs. Cheng might then become unhappy and miserable which might gradually caused her to become depressed or even suicidal since there is also no caregiver support for her as the rest of her family died in the tsunami. Thus, the nurse should not ask Mrs. Cheng to refrain from going out to smoke as they will be doing harm to the patient and violating the ethical principle of non-maleficence.

Justice refers to what the general public deems as right and fair (Hawley, G., 1997, p.26). To deprive an elderly patient of what she would like to do in the last one month of her life is simply cruel and unjust. To utilize manpower to accompany a patient just for smoking 5 hours a day when the nurse would be able to do more for other patients in the ward is a waste of manpower as well as tax payers’ money. It is also unfair to the other staffs that have to cover extra duties while this particular staff is away in the garden with Mrs. Cheng. Due to shortage of manpower and unfinished work, the staffs might have to stay back to finish their work, taking up their personal time which could be spend with their own family. Quality and duty of care to the rest of the patients might be in question if the remaining nurses in the ward have to rush to finish their work before the shift ends.

Identify ethical conflicts

Beneficence versus Non-maleficence

Often a healthcare professional’s good intention might not be what is best for the patient. Though to stop smoking has its benefits to health, it seems almost futile to ask a person who only has one month of lifespan to quit smoking. For a smoking cessation program to succeed, it would take more than a month, not to mention Mrs. Cheng has to endure the unpleasant withdrawal effects and unhappiness in the last few weeks of her life of not having to smoke (Zow, Hsu, and Eng, 2004). To resolve the conflict between the two principles of ethics, one needs to weigh the risk and benefits between the two to make a decision (Pantilat, 2008).

Autonomy versus Beneficence

Autonomy requires the staff to respect the patient’s decisions whereas beneficence requires the staff to make decision in the patient’s best interest, to remove harm and to do good. These two principles conflicted as a result when what a patient wants is deemed harmful to her health and as a healthcare worker, the responsibly is to remove the harm. To resolve it, the healthcare worker should respect that the patient decision as long as it is made in a state of sound mind and continue to try to convince the patient otherwise by making sure that patient has all the information she needs to make a correct decision (Pantilat, 2008).

Consider the Law

Duty of care

A nurse owes a duty of care to a patient, where there is a nurse-patient relationship that creates that duty. (Corcoran, 2000) In this case, the staffs of the medical ward owe Mrs. Cheng a duty to see to her needs and wellbeing, ensuring safety by accompanying Mrs. Cheng to the garden being one of it. The nurse accompanying have the option of wearing a N95 mask supplied by the hospital for protection against the organic vapors from the cigarette smoke. (Mask and More, 2010)

Patient advocacy

According to Singapore Nursing Board (SNB), Code of Ethics and Professional Conduct, Value Statement 7(2006), the nurses need to advocate in the best interest of the clients, by “ensuring clients’ interest and needs are recognized and considered by the entire healthcare team” and also protecting the clients from any form of coercion to involuntarily agreed to accept or change their decision. In this scenario when some nurses are advocating for the other patients’ quality of care, it is very important to ensure that the nurses also advocate for Mrs. Cheng’s interest and needs as well so as to ensure fair treatment of all patient irregardless of race or age. (SNB Code of Ethics and Professional Conduct, Value Statement 1, 2006)

Nurses and Midwives Act

Any registered nurse or enrolled nurse found to have been guilty of misconduct or negligence shall either be imposed a fine upon, have their registration suspended or terminated. (Nurses and Midwives Act, Section 19, 2a-d) By breaching the duty of care not abiding by the SNB Code of Ethics and Professional Conducts, the nurses are likely to be guilty of misconduct or even negligence if relations are proven between the breach of duty and the injury caused (Nair, n.d.).

Consent to Medical Treatment & Palliative Act 1995

“Medical Practitioners in the practice of palliative care for patients in the terminal phase of a terminal illness are protected from civil and criminal liability by the Act if they administer treatment only to relieve pain and distress, even though an incidental effect of the treatment is to hasten death, provided they act with consent; in good faith and without negligence; and in accordance with proper professional standards of palliative care”. (Consent to Medical Treatment and Palliative Act 1995, Section 7.1) In this case, Nicotine patch could be a consideration provided that patient consented to using it. It can be administered to relieve the urge to smoke thus preventing patient from suffering from the withdrawal when the staff is unavailable to bring her to the garden to smoke.

Capacity to give consent

According to the Mental Capacity Act 2008, Section 3 (21, 4), a person is assumed to have mental capacity unless proven otherwise, and should not be deemed as incapable of making a decision simply just because he or she made an unwise decision. Thus it is to assume that Mrs. Cheng is capable of making decisions for herself in terms of treatment and among other things. The palliative team should then come together with patient to discuss issues, propose suggestion(s), provide relevant information and allow the patient to make a decision for herself.

Relationship between the clinical-ethical decision and the law

In nursing, decisions made regarding patients’ care and needs are always based on the ethics and standard of practice that the Nursing Board or Council upholds. The Code of Ethics and Professional Conducts, Standard of Practice and Competency Standards are all in turn, written according to the Law in terms of legislation that govern it, e.g. Nurses and Midwives Act.

Making the ethical decision

Ethical decision

The author believes that Mrs. Cheng should be allowed to continue to go to the outside garden to smoke in the company of a nursing staff if she chose to. This decision is justified by balancing the principles of ethics and by following the Australian Nurses and Midwifery Council (ANMC) Code of Ethics and the SNB Code of Ethics and Professional Conducts.

Nurses are to promote and uphold patient’s autonomy by respecting the informed decision made by the patient concerning their own care. (SNB Code of Ethics and Professional Code of Conduct, Value Statement 2, 2006) Thus if Mrs. Cheng’s decision is to continue smoking despite being informed and educated on the hazards of smoking, then the nurses should accept and respect that decision.

According to ANMC, Code of Ethics, Value Statement 2.3, nurses who are indifferent to her colleagues’ plight, manipulative and bullying their colleagues are basically just disrespectful towards others and are ethically intolerable. Thus some of the staff from the ward should not use resignation to coerce the management or the rest of the nurses to agree to a decision that they are in favour of but might not be beneficial to the patient.

Document the decision

Effective documentation provides evidence to show that individualized nursing care and the patient’s response to that care outcome. Proper documentation of the quality care the nurses have given ensure that they would be able to defend themselves in court if they were being subpoenaed (Henderson, 2010).

The documentation would include the date and time, names of the people who are present during the discussion, topics discussed for e.g. no smoking policy, assigning additional staff on each shift, and the understanding of the patient of these topics, comments from various parties including the patients, and the final decision, the plans to follow up and schedule a time for evaluation. The documentation of the decision will be done in a clear manner and according to the organizational guidelines. (ANMC Registered Nurse Competency Standards 6.3 and 10.3) The patient’s mental capacity will also be documented by the team doctor present at the discussion to ensure that patient did not agree to any decision when she is in a vulnerable state of mind (A Guide for Healthcare Professionals, n.d.).

Evaluate the decision

Evaluation must be done throughout the whole process and not just at the end of it as it is a process of gathering data and analyzing it, using the information gathered to determine whether the plan is progressing towards the objectives and planned outcomes set initially (The Importance of Evaluation, 2005). In order for the plan of care to succeed, continuous supervision, evaluation and revise of plan of care in accordance with evaluation data is needed. (ANMC Standard of Practice, Standard 8.1 & 8.2, 2008 and Standard 3 of SNB Standard of Practice, 2006).

Total word count: 2487

Reference List

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A person who has cholera would be expected to have which type of diarrhea?What pathologic alteration produces tremors at rest, rigidity, akinesia, and postural abnormalities?

A person who has cholera would be expected to have which type of diarrhea?What pathologic alteration produces tremors at rest, rigidity, akinesia, and postural abnormalities?

1. Question : Cerebral edema is an increase in the fluid content of the

2. Question : Vomiting is associated with CNS injuries that compress which anatomic location(s)?

3. Question : What is the best prognostic indicator of recovery of consciousness or functional outcome?

4. Question : With receptive dysphasia (fluent), the individual is able to

5. Question : The body compensates to a rise in intracranial pressure by first displacing

6. Question : Characteristics of primary motor neuron amyotrophy include

7. Question : In Parkinson disease (PD), the basal ganglia influences the hypothalamic function to produce which grouping of clinical manifestations?

8. Question : What pathologic alteration produces tremors at rest, rigidity, akinesia, and postural abnormalities?

9. Question : Multiple sclerosis (MS) and Guillain-Barré syndrome (GBS) are similar in that they both

10. Question : The edema of the upper cervical cord after spinal cord injury is considered life threatening because of

11. Question : A man who sustained a cervical spinal cord injury 2 days ago suddenly develops severe hypertension and bradycardia. He reports severe head pain and blurred vision. The most likely explanation for these clinical manifestations is that he is

12. Question : Spinal cord injuries are most likely to occur in which of the following regions?

13. Question : Which neurotransmitter receptors are blocked by antipsychotic drugs?

14. Question : Which neurotransmitter is inhibited in generalized anxiety disorder (GAD)?

15. Question : Which electrolyte imbalance contributes to lithium toxicity?

16. Question : A _____ is the test done on amniotic fluid and maternal blood to test for neural tube defect.

17. Question : Anterior midline defects of neural tube closure cause developmental defects in the

18. Question : The clinical manifestations of dyskinetic cerebral palsy include

19. Question : A person who has cholera would be expected to have which type of diarrhea?

20. Question : The most common manifestation of portal hypertension induced splenomegaly is

21. Question : The desire to eat is stimulated by

22. Question : Meconium _____ is an intestinal obstruction caused by meconium formed in utero that is abnormally sticky and adheres firmly to the mucosa of the small intestine.

23. Question : Congenital aganglionic megacolon (Hirschsprung disease) involves inadequate motility of the colon caused by neural malformation of the _____ nervous system.

24. Question : Which disorder is characterized by an increase in the percentages in T cells and complement together with IgA and IgM antigliadin antibodies found in jejunum fluid?

25. Question : Which of the following medications compensates for the deficiency that occurs as a result of cystic fibrosis?

Literature Review Tuberculosis Article Health And Social Care Essay

According to the World Health Organization, a third of the world’s population is infected with Mycobacterium tuberculosis (World Health Organization). New cases were estimated to number 9.4 million with 1.8 million deaths in 2008 (Thomas). Gary Maartens and Robert J. Wilkinson published a review in the December, 2007 issue of The Lancet that outlines the current condition of tuberculosis(TB) in the world today. Specifically, the authors report on the status of research, diagnostic techniques, treatment options and the epidemic of HIV-associated tuberculosis in Africa.

Mycobacterium tuberculosis is the bacterial causative agent of a disease that has been a leading cause of death for much of earth’s history and still is for many developing countries. Maarten and Wilkinson noted recent regional changes in the incidence of TB with improvements made in many regions while incidence in sub-Saharan Africa has increased. This increase is correlated with the HIV epidemic in Africa and presents complex challenges in the task of controlling TB. In addition to HIV, multidrug-resistant and extensively drug-resistant (XDR) strains of tuberculosis account for increasing numbers of new cases and recurrent disease in previously treated patients. The authors state that 4% of patients worldwide have a multidrug-resistant strain. Included in that percentage are patients with XDR strains. One reported study of a tuberculosis outbreak in HIV-infected individuals showed that 24% of those patients had XDR strains and this resulted in a 98% fatality rate (52 of 53 patients). Genetic analysis of the bacterium indicated that transmission of the TB had been recent and it was noted that two-thirds of the affected patients had been hospitalized in the two years prior. The concern is that they may have acquired the XDR strain of TB while hospitalized, highlighting the need for better treatments and more precaution when treating these patients. Without improvements in rapid diagnosis and treatment, the incidence of drug-resistant strains will continue to rise.

Genomic analysis has become an important tool in understanding microorganisms and Mycobacterium tuberculosis has been extensively studied and its genes have been sequenced. Analysis conducted on 875 different strains of Mycobacterium tuberculosis from 80 countries has resulted in the discovery of six distinct lineages of TB that seem to have adaptations to specific populations of humans. As an example, the east African-Asian strain affects people of Indian origin, regardless of where they currently live. Another strain, W/Beijing, has less specificity, affecting people all over the world, but it also seems to be more virulent. Each of these strains is the result of mutations in the DNA of the bacterium. Different strains of TB have different mechanisms which allow them to modulate or suppress the immune system response. Many of these mechanisms have to do with the molecules that comprise the mycobacterial cell wall such as phenolic glycolipids. Two large studies have identified that membrane-associated proteins, molecular transporters, and ion channels play a vital role in the virulence of TB. These discoveries not only help scientists better understand the pathogenesis of tuberculosis; they also provide new targets for treatment.

In addition to the genetics of the bacteria, the genetic makeup of the host is critical. Specific receptors on human macrophages recognize specific molecules of the cell wall of Mycobacterium tuberculosis and trigger cellular signaling cascades that can result in greater host resistance or increased susceptibility to TB. Two of the receptors involved have a role in vitamin D activation and a deficiency of this vitamin has been noted in some tuberculosis cases, leading the authors to speculate about the possibility of vitamin D supplementation for prevention. Mutations in one of these cellular signaling pathways were shown in a series of studies to predispose individuals to “severe atypical mycobacterial infections.” This line of inquiry, identifying the specific genetic mutations that give rise to virulence factors in the bacteria or greater susceptibility in the host, could lead to huge advancements in the understanding and eventual eradication of TB, but the authors point out that these studies would need to be extensive, which equates to expensive.

Diagnosis and treatment for tuberculosis hasn’t significantly changed in decades. Microscopic analysis and bacterial culturing are the standard protocols used to detect a TB infection, but these techniques have drawbacks, the most obvious being the time and labor involved in culturing. Maarten and Wilkinson state the obvious by expressing a desire for a more sensitive test that is rapid and affordable. A few emerging candidates are discussed, including nucleic-acid amplification tests and enzyme-linked immunospot analysis (ELISpot analysis). Nucleic-acid amplification tests have not proven to be significantly better at identifying TB. They are also expensive and require specialized equipment, making them unsuitable for use in most developing countries with limited resources. The ELISpot analysis, however, has promise in that it shows greater sensitivity and specificity than the tuberculosis skin test (TST), particularly in differentiating between exposure to TB and an active infection. In addition to assessing whether a patient is dealing with a tuberculosis infection, it is critical to know whether the strain of TB is drug-resistant. Current methods of determining drug resistance require 6-8 weeks, but microscopic analysis of liquid culture growth can be done within 10 days and has the advantages of being inexpensive and easily available, even to locations with limited resources. HIV infection further complicates diagnosis of tuberculosis and a determination is frequently made based solely on clinical symptoms and x-rays. This can lead to faster treatment, but could also be a contributing factor in the creation of resistant strains.

Current methods of treatment involve a cocktail of medications taken for at least six months. This protocol typically has good results, even in patients with HIV. The treatment strategy utilized internationally is called “directly observed treatment short course (DOTS).” This method of control has contributed to gains made in prevention, diagnosis, and treatment, but still has many shortcomings. The authors advocate a combined approach and point to very high adherence rates for HIV treatments with a more patient centered approach, which empowers the patient to take care of themselves rather than reporting to a clinic to be observed taking a medication.

The medications used to treat TB have changed very little and new medications are desperately needed, especially in light of the increase in drug-resistant strains. A commonly used medication, rifamycin is proving to be less effective in patients with HIV due to the development of resistance or because of some metabolic process reducing the concentration of the medication in their bodies. Fluoroquinolones have been shown to be effective but seem to be prone to rapid development of resistance and toxicity. The authors report on two new antimycobaterial drugs that have novel mechanisms of action and are in the process of testing.

The complications of treating patients with HIV and TB are many. Most of the symptoms of TB are due to immune response (immunopathological), but the immune systems of HIV patients are already suppressed. The medications to treat TB can further suppress the immune response leading to an increase in viral load and the possibility of more opportunistic infections. In addition, many of these medications have proven to be hepatotoxic, which HIV patients are even less equipped to handle. Complications can also include “paradoxical deterioration” whereby the treatment of HIV results in a worsening of TB symptoms. The important point is that more research is required to understand the immune system functionality in concurrent infections of TB and HIV.

The treatment of latent infections is aimed at preventing these infections from becoming active, particularly in immunocompromised patients. The most common strategy is a 6-12 month course of isoniazid. Although widely used, this treatment carries the same risks of medication resistance and hepatotoxicity as other TB drugs. Additional information on the physiology of latent infections could lead to better drugs and better strategies for treatment.

Vaccination, which is widely available in Europe, but not used in the United States, has shown some efficacy in preventing severe TB infections in children, but the length and strength of protection is in question. Tuberculosis is still transmitted, allowing the continued spread of the bacteria. Novel vaccines are being tested and a few show promise to provide better protection. The authors reiterate the need for large, long term studies.

Sub-Saharan Africa is experiencing an epidemic of HIV-associated tuberculosis. The capacity to manage this epidemic is severely hindered by socioeconomic, medical infrastructure, and political issues. Treating with antiretrovirals has reduced the number of cases of tuberculosis, but HIV patients are still much more likely to develop tuberculosis. The best preventative measure seems to be to reduce the incidence of HIV and the best treatment strategy is to identify and treat active tuberculosis. Treating both HIV and tuberculosis concurrently poses special problems. Many of the drugs have potentially negative interactions, either reducing efficacy or increasing toxicity. In addition, there is the possibility of immune reconstitution inflammatory syndrome. This disorder manifests as a worsening of TB symptoms in a patient that was improving, likely due to an improved immune response resulting from treatment of HIV. In essence, successful treatment of HIV results in an escalation of tuberculosis symptoms. Steroids used to treat the TB have some success, but at the risk of increased complications from HIV. There is a fine line in concurrently treating these diseases and much more to understand about it.

This article serves both as a reminder of the enormity of the problems associated with Mycobacterium tuberculosis and as a call to arms for more research. With a third of the world’s population affected, it is extremely surprising that we don’t have a symbol, a color, a celebrity backed telethon with accompanying song, or a three-day walk to raise awareness and money for research. I suppose part of the problem is that the problem is “over there” and so we in America are less aware. Preventing the spread of the bacteria seems to be the best option for a long term reduction in incidence, and a new vaccine would seem to be the logical next step. In reading the article, it seems the challenges in treating tuberculosis are almost overwhelming. Tuberculosis lives and multiplies in the macrophages of the human immune system, the very cells that would normally play a key role in eradication of a bacterial infection. This uncommon arrangement, in addition to the complexity of the interactions between humans and Mycobacterium tuberculosis, is key to understanding the disease in the hope of finding better solutions. If we could find a way to induce the body’s immune systems to attack the bacteria itself without the formation of tubercles or other negative effects, that would be an ideal solution. If that is not possible, we need to find those mechanisms or characteristics that are unique to the bacterium or its pathogenesis and create a drug to act on those. The challenges are many. The authors repeatedly used the term “political will” and it seems that this may be the key to resolving the problem of tuberculosis. While the article serves the purposes of reminding and rallying, it seems to be written for those already familiar with the disease and is poorly organized. The authors seem to “hopscotch” about with very little in the way of transition, making it difficult for a novice to assimilate the information. It is a good review of the current direction, but without the foundational information required to understand what it means.

Detection and Classification of Leukaemia Cells

Leukemia is one of the many types of cancers. Leukemia is caused in the white blood cells near the bone marrow region of our body. In this the WBCs which get infected turns blue. Like any other cancer in this also the cell divides itself at the faster pace. Most human cancers are characterized by the aberrant expression of normal and/or mutated genes, and natural selection acts on cancer cells to cause a loss of growth control, angiogenesis, invasion, and metastasis. Even when it is not required they multiply causing a tumor. Detected and treated at an early stage of leukemia saves a lot of lives. The aim of this research is to automate the detection of leukemia cells. In the scientific language, the leukemia cells are known as the blast cells. There are two types of acute leukemia, Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML). This thesis focuses on Acute Lymphoblastic Leukemia (ALL). Generally, the process of detection and classification is done manually taking up to five days. The motivation behind this research is to improve the diagnostic process by automating it and reducing its time span to five days to few hours. Nowadays, medical imaging is one of the fastest growing fields in medicine, clinical settings and research and development (R&D).

Image processing in medical field is becoming a subject of prime focus due to its tremendous potential for the public health sector and the scientific community in general. In particular, imaging applications are emerging as a new opportunity as an innovation at the meeting point between medicine and the computer science. Many software and research groups focus on the development of image processing applications for medical images, for example to improve low resolution photographic images and produce effective – high quality images.

There is no terrifying disease than cancer nowadays. It is often seen as untreatable, un curable and a very painful disease.

Leukemia detection helps in detecting blood cancer using two basic modules of image processing i.e. Image segmentation and feature extraction. After these two modules, we use two techniques of neural network i.e. feed forward network and RBFNN for the detection purposes. We compare the accuracy percentage in both of them. The technique with best accuracy percentage is recorded as the more efficient technique. More than 310,000 Americans are living with leukemia. Every day 143 Americansare detectedwith leukemia and 66 lose the fight. [23]

A brief overview of leukemia and a conceptual analysis of the main methods used for the detection and classification of leukemia cells facilitating Artificial Intelligence, Cellular Automata and Neural Networks are discussed below.

Cancer has become a data-intensive range of investigation, with growing amount of changes in data collection technologies and methodologies. In 1895, Wilhelm Roentgen discovered that X-ray tubes, utilized widely for imaging bones and then for giving a variety of circumstances. The technicians who ran the radiograph machines and many exposed patients were found with skin tumors and leukemia. Accurate diagnosis and sorting of blast cells is an tremendously valuable necessity for the detailed diagnosis of leukemia and has a optimistic impact on treatment and prognosis.

  1. BLOOD

Blood is important part of human life. An average human body is around 70 liters of liquid from which five liters is blood. Biologically, blood is vital for preserving homeostasis that is keeping the body’s position stable. This discusses to hydration, temperature regulation and ion concentration.

a) Transfer of nutrients from the digestive system to wholly parts of the body.

b) Transportation of oxygen from the lungs to all parts of a body.

c) Transportation of carbon dioxide from all parts of the body to the lungs.

d) Transportation of waste products from cells to the external environment, especially via the kidneys.

e) Keeping an ongoing discussion of it is mechanisms with tissue fluids and keeping electrolyte balance.

f) Defending the body against attack from foreign viruses through the white blood cells and antibodies.

g) Shielding the body against injury or illness using the provocative response.

h) Preventing serious hemorrhage by the clotting process.

Blood has four main fundamentals to ensure it fulfills its functions, shown in Table 1.1


ELEMENTS

DESCRIPTION
Red blood cells (RBC’s or erythrocytes)

Transportation of oxygen from the lungs to organs and peripheral site.
White blood cells

Protective role in abolishing invading organisms, e.g. bacteria and viruses and assist in the removal of dead or damaged tissue cells.
Platelets

Help in the clotting process.


Table 1.1 (a):

Major elements of Blood (Red blood cells, White blood cells, Platelets).


ELEMENTS

DESCRIPTION
Plasma

Transmits nutrients, metabolites antibodies and the proteins included in blood clotting.


Table 1.1(b):

Major elements of Blood (Plasma).

1.1.2 WHITE BLOOD CELLS

A white blood cell is superior to a red blood cell. White blood cell arrangement and concentration in the blood gives appreciated information and plays a crucial role in the diagnosis of different diseases. White blood cells fall into five categories: Neutrophil, Eosinophil, Basophil, Monocyte and Lymphocyte, shown in the Table 1.2. These cells afford the greatest defense against infections, and their discrete concentrations can help authorities to distinguish between the presences or not of severe pathologies.

Types of blood cells are discussed in the following table


ELEMENTS

DESCRIPTION
Neutrophil

This cell has a characteristic nucleus, consisting of between two and five lobes, and a pale cytoplasm. The grains are divided into primary, which appear at the promyelocyte stage, and secondary which perform at the myelocyte stage. The lifespan of neutrophils in the blood is only about 10h.
Eosinophil

These cells are similar to neutrophils, except that the cytoplasmic grains are coarser and more deeply red staining. They enter inflammatory exudates and have a special role in allergic responses. They provide protection against parasites and help the removal of fibrin formed during inflammation.
Basophil

Basophil cells are only seen in normal peripheral blood. They have many dark cytoplasmic granules, which overlie the nucleus and contain heparin and histamine. Size: 9-10 μm in diameter.
Monocyte

These are frequently larger than other peripheral blood leucocytes. The monocyte precursors in the marrow (monoblasts and promonocytes) are difficult to distinguish from myoblasts and monocytes. Monocytes spend only a short time in the marrow and after circulating for 20-40 hours, leave the blood to arrive in the tissues where they mature and carry out their principal functions. Size: 16-20 μm in diameter
Lymphocyte

These are the immunologically competent cells which support the phagocytes in the defense of the body against infection and other foreign invasion. Two unique features characteristic of the immune system are the ability to generate antigenic specificity and the phenomenon of immunological recall. Size: 8-10 μm in diameter.


Table 1.2 :

White Blood Cells (Neutrophil, Eosinophil, Basophil, monocyte, lymphocyte)

1.1.3 TYPES OF LEUKEMIA

Leukemia is a sickness of unidentified cause where the bone marrow produces huge numbers of irregular cells white blood cells that stop increasing before maturity. There are four main types of leukemia, namely Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), which is used as a case study in the thesis, Chronic Lymphocytic Leukemia (CLL) and Chronic Myeloid Leukemia (CML). Most commonly, acute leukemia patients are discussed to specialist units for evaluation. Treatment is based on chemotherapy through the veins, lasting four to six months, which also kills normal body cells. Leukemia can be identified by blood tests while a bone marrow test assists to choose on the best choice of treatment. Table 1.3 includes the types of main leukemia.


TYPES

DESCRIPTIONS
Acute Lymphoblastic Leukemia (ALL)

The most common type of leukemia in young children. This disease also affects adults, especially over the age of 65.
Acute Myeloid Leukemia (AML)

It develops in both adults and children
Chronic Myeloid Leukemia

It occurs mainly in adults. A very small number will infect the children.
Chronic Lymphocytic Leukemia (CLL)

Most commonly it affects adults over the age of 55. It sometimes occurs in younger adults, but it almost never affects children.


Table 1.3 :

Types of Leukemia

Table below shows the UK Leukemia case statistics for males and females in 2007, revealing that the survival rate has increased from 2001 to 2006. The diagnosis and the medical treatment have improved significantly as shown in Figure 2.1. Automated detecting can contribute to the early diagnosis of patients and survival rates are expected to increase in the future.


Table 1.4:

Leukemia cases in UK for 2007


Figure 1.1:

Leukemia 10-year relative survival rates

1.1.4 FLOW CHART OF THE PEOPLE ADMITTED IN THE HOSPITAL

Figure 1.2 shows the steps that are essential to be taken by a hematologist in order to identify a patient with acute leukemia. Table 1.5 provides a more thorough explanation of the individual steps in Figure 1.2


NO

YES




NOYES


STEPS

DESCRIPTIONS
1 Patient admitted in hospital.
2 In acute leukemia patients, the White Blood Cell (WBC) count and morphology will be irregular.

Doctor will suspect that a patient has leukemia based on:

a) Clinical presentation: patient presented with hepatosplenomegaly and/or lymphadenopathy.

b) Abnormal blood count: hemoglobin and platelet count is low; WBC is normal, low or high.

Blood test will be taken from the patient.

In a healthy adult the differential WBC test should show the following results:

Neutrophil – 40% – 70%

Eosinophil – 5%

Basophil – 1%

Monocyte – 6% – 10%

Lymphocyte – 20% – 50%

The blood count will be performed by the Machine.

In case of clinically suspicious and abnormal blood count specimens a blood smear is prepared and the slide is referred to a hematologist for examination.

3

The blood smear is scanned through a microscope by a hematologist.

4

If the blood smear test reveals no evidence of leukemia, i.e.

normal blood cell count and morphology, other underlying causes need to be investigated

5

If the patient is suspected of suffering from leukemia, bone marrow sample is required to confirm the diagnosis.

6

The marrow smear is scanned under a microscope by a hematologist with 10x, 40x and 100x magnifying power

.

7

The hematologist will calculate the WBC differential count manually preferably based on 300-500 cells.

8

Blasts should account for about 20% of cells, based on the WHO classification. Less than 5% is considered normal.


Table 1.5 :

Analytical description of each step in Figure 1.2

Asthma and the School-Age Child: The 6 Year Old


Lorna V. Tablazon


Karen Rouleau

Asthma is a chronic (long-term) disease that makes it hard to breathe. Asthma can’t be cured, but it can be managed. With proper treatment, people with asthma can lead normal, active lives (Canadian Lung Association, 2014). There can be many causes for asthma, it may run in the family through genetics or might be from air pollutants in the outside environment. The one point to remember is that even when symptoms are mild, asthma should not be ignored. Untreated or under treated, asthma can lead to severe respiratory distress and in rare cases, sudden death. This paper will be discussing about dealing with a child with asthma. The main focus will be on school-age children, specifically, a 6 year old child.


Pathophysiology


Signs and Symptoms of Asthma

According to Wicks (2006), early signs and symptoms of asthma include stuffy nose with congestion, irritating cough, sneezing bouts, headache, face becoming pale or flushed, and fever (p. 27-28). With mild persistent asthma, symptoms of cough, wheezing, chest tightness, or difficulty breather occur (Rosto, 2009).


Course of Illness

In response to contact with a triggering substance or mechanism, mast cells of the immune system, which are found in loose connective tissue, are responsible for releasing vasoactive (action on vessels) chemical mediators, including histamine, bradykinin, leukotrienes, cytokines and prostaglandins. Chemotactic (produces specific cell movement) chemical mediators released from the mast cells cause neutrophils, lymphocytes and eosinophils to infiltrate the cells of the bronchial lining. These target the respiratory system and cause bronchoconstriction, vascular congestion, vasodilation, increases in capillary permeability, mucosal edema, impaired mucociliary action (removal of mucus and contaminants within the bronchial tree by movement of the cilia inside the bronchioles), and increased mucus production, which leads to an increase in airway resistance. Mucus plugging may also occur in the smaller bronchioles. These pathophysiologic factors produce the typical clinical presentation of asthma, including wheezing and respiratory distress (Limmer et al., 2004)


Prognosis

According to some studies, asthma disappears in 30 to 50 per cent of children at puberty, but often reappears in adult life. Up to two-thirds of children with asthma continue to suffer from the disorder from puberty and adulthood. Moreover, even when asthma has clinically disappeared, the lung function of the patient frequently remains altered, or airway hyper-responsiveness or cough may persist. Children with mild asthma are likely to have good prognosis, but children with moderate or severe persistent asthma probably continue to have some degree of airway hyper-responsiveness and will be at risk of having asthma throughout life (Gupta et al., 2001).


Admission to the Hospital


Safety Concerns

Children with asthma that are hospitalized are vulnerable to pathogens and allergens that are present in the new environment. There are safety concerns that a nurse must be aware of when caring for a child with asthma. First, check for the oxygen saturation of the child. Children with life-threatening asthma or SpO2 <92% should receive high flow oxygen via facemask or nasal cannula (Borton, 2010). Another one is to know what allergens might trigger the child’s asthma attack. The hospital is an open environment where people come and go, therefore, contaminants and allergens from the outside environment may possibly be present in the hospital setting. Lastly, is the child’s risk for falls. Falls account for 35% to 40% of injuries (Warda, 2004).


Age Appropriate Toys

Play activities in the school-age child involves increased physical and intellectual skills and some fantasy (Leifer, 2011). Toys such as construction sets, help develop hand control. School-age children prefer a wide range of art materials, such as sparkles, fine brushes, hole-punchers, and tape dispensers. A wide variety of different artistic mediums also encourage children to be creative and use their imagination. Lastly, choose challenging board games, since children are now able to understand rules and interact with their peers (NYCDS, n.d). Rituals such as collecting items and playing board games are also enjoyable quiet activities for the school-age child (Leifer, 2011).


Impact of Hospitalization

Being hospitalized due to asthma can have a huge impact, not only to the child, but also toward the family. Asthma is a leading cause of absenteeism in school students, which in severe cases can cause them to fall behind in their work (Asthma Australia, n.d.). Another thing to note is that when hospitalized, some children can regress in behavior and become overly dependent on their parents (PICS, n.d). Lastly, if the hospitalized child has siblings, they may get affected too. When one child in a family has to receive medical care, the experience can be upsetting to his/her siblings. Some emotional responses of these siblings may include: feelings of abandonment, rejection and isolation (Children’s Specialized Hospital, 2014).


Communication Techniques

Communicating with a 6 year old does present some challenges. They tend to be bossy, are sometimes rude, and experiment with language, but they are very sensitive to criticism (Leifer, 2011). One method for successful communication with school age children is to start and agreement, not an argument (PBSparents, 2014). This can be done by asking the child something where the final answer would be an agreement. For example, asking the child which arm they would prefer when starting an intravenous line instead of saying that it should only be done in the right arm. The hospitalization of children can have an impact on parents too. To communicate better with the parents, the nurse can provide an advice page, covering topics such as how to explain to kids what will happen in the hospital and how to comfort their children (Blackstone & Pressman, n.d.). Lastly, School-age children can handle more pieces of information at the same time (Gable, 2003). To effectively make the child understand what is happening, the nurse can describe the illness using simple concepts (Goldman, & Mathews, n.d.). For example, explain to the child that he is being admitted to the hospital not because he is being a bad child, but because of his illness.


Baseline Data

To better aid in diagnosing or rendering care for a child with asthma, certain baseline data has to be taken during the child’s assessment. First is to check for known allergies. In many cases, allergy information helps medical personnel discover a cause for problems like swelling or difficulty breathing. Second is to check for pre-existing illnesses or conditions. Pre-existing illnesses or conditions can have a great impact on the kinds of tests or treatments administered during an emergency. Third is to check for immunizations done. Lastly, check for previous hospitalizations and operations. This information may help during and following an emergency situation (Dowshen, 2013).


Conclusion

School-age children, especially the 6 year old, do present challenges when it comes to rendering care. According to Leifer (2011), children may be unable to verbalize their needs (p. 436), therefore the nurse in collaboration with the parents and the rest of the health care team must work together in coming up with techniques and strategies to be able to render the best means of care for a school-age child.

References

Asthma Australia. (n.d.).

Asthma in school-aged children.

Retrieved from

http://www.asthmaaustralia.org.au/asthma_in_school_aged_children.aspx

Blackstone, S., & Pressman, H., (n.d.).

Effective communication in children’s hospitals.

Retrieved from

http://www.patientprovidercommunication.org/pdf/25.pdf

Borton, C. (2010).

Management of childhood asthma.

Retrieved from

http://www.patient.co.uk/doctor/management-of-childhood-asthma

Canadian Lung Association. (2014).

Asthma.

Retrieved from

https://www.lung.ca/diseases-maladies/asthma-asthme/what-quoi/index_e.php

Children’s Specialized Hospital. (2014).

Effects of hospitalization on siblings.

Retrieved from

http://www.childrens-specialized.org/Programs-Services/Specialty-Programs/Recreational-Therapy-and-Child-Life/About-Child-Life/Sibling-Support/Effect-of-Hospitalization-on-Siblings.aspx

Dowshen, S. (2013).

Knowing your child’s medical history.

Retrieved from

https://www.akronchildrens.org/cms/kidshealth/2104a0fe743eca5e/

Goldman, S., & Mathews, M., (n.d.).

Parenting strategies.

Retrieved from

http://www.pbs.org/opb/childrenshospital/parents/pop/pop-ts_communicate.htm?500

Gupta, A., Gupta, R., Kushwaka, KP., & Bansal, H. (2001).

Asthma care and management,


guidelines for doctors.

India: Jaypee Brothers Publisher

Liefer, G. (2011).

Introduction to maternity and pediatric nursing 6



th



ed.

USA: Elsevier Limmer, D., Mistovich, J.J., Krost, W.S. (2004).

Pathophysiology of asthma.

Retrieved from

http://www.emsworld.com/article/10324789/pathophysiology-of-asthma

NYCDS. (n.d.).

You and your family: childcare and parenting.

Retrieved from

http://www.nebenefit.com/nycds/resource_ctr/index.aspx?thePage=ynyr_family/childcare/play/choose_toys.ascx&subnav=rc&sidenav=rc

PBSparents. (n.d.).

Strategies for working out.

Retrieved from

http://www.pbs.org/parents/talkingwithkids/negotiate_2.html

Pediatric Integrated Cancer Service. (n.d.).

Impact of hospitalization on children and


adolescents.

Retrieved from

http://www.pics.org.au/Impactofhospitalisationonchildre nandadolescents

Rosto, E. (2009).

Pathophysiology made incredibly easy.

USA: Lippincott Williams & Wilkins

Warda, L. (2004).

Is your hospital safe for children? Applying home safetfy principles to the


hospital setting.

Retrieved from

http://www.ncbi.nlm.nih.gov/

pmc/articles/PMC2721182/#

Wicks, S. (2006).

All about asthma: what you need to know.

USA: eFortune US

Discuss how and why the outcome would have changed if the facts or evidence had been different. Ethical and Legal considerations, medical malpractice.

Discuss how and why the outcome would have changed if the facts or evidence had been different. Ethical and Legal considerations, medical malpractice.

Discuss how and why the outcome would have changed if the facts or evidence had been different. Ethical and Legal considerations, medical malpractice. I need…

Discuss how and why the outcome would have changed if the facts or evidence had been different.
Ethical and Legal considerations, medical malpractice.
I need an outline first and then the final paper as detailed below:
One of the most important objectives of this course is for you to be able to relate the theories in the readings and discussions to situations in real life. We will develop these critical thinking skills each week via the discussion boards and short writing assignments, which will culminate in the final project, a medical malpractice case study.
The purpose of a case study in general is to apply what you learned to a real-life or hypothetical situation where you analyze, test, and propose solutions to the case. You may have a problem to solve and be asked to present potential solutions. Or you may have a situation to analyze and describe why (or why not) certain events were effective or successful. In processing a case study, you will have to apply research, reasoning, critical thinking, and analytical skills to identify underlying problems, causes, and/or related factors and make decisions.
For the medical malpractice case study, you will prepare a paper discussing a medical malpractice case using the DIRAC (issue, rule, analysis, conclusion) formula. You will discuss any relevant ethical theories involved and analyze the outcome, applying legal concepts from the course.
You should be thinking about your case and start your research by Module Three. By Module Five, you should finalize your choice of a reported case for your project. In the Module Five journal activity, you will be asked to briefly discuss your chosen case and provide an outline for your project. The final project is due at the end of Module Seven.

Effective Communication and Professionalism with Patients


Section 1 “Professional capabilities”

Domain2: Professional Communication and Collaboration

It is important and essential for health professionals to improve on communication skills with patients in daily medical settings. Diverse cultural backgrounds, various physical and mental conditions of patients also need to be considered seriously and respectfully. According to O’Daniel and Rosenstein (2008), effective communication encourages collaboration and helps prevent medical errors.

There was a good example from my first clinical placement in 2018. The case was related to effective communication with the patient.

J.W is a 43 years old Italian woman who has been referred to the medical imaging centre for X-ray assessments. According to Dauer et al. (2013), the perceptions of patients regarding to the X-ray examination could be affected by the communication approach taken by the radiographer.  In other words. it is suggested that the responsibility of the radiographer to clearly deliver accurate information such as risks, benefits and the whole process of the X-ray examination plays an important role in effective communication with the patient.

Appropriate and effective communication in this case involves various aspect, for example, the respectful attitude towards patients, the display of professional conduct, giving understandable instructions, providing post examination care if necessary. The relationship between radiographers and patients can thus be strengthened if effective communication implemented.  Most patients are actually with little conceptions about the exam they are having. Thus, information given from radiographers in this stage becomes extremely critical to them. Sufficient clinical information obtained from patients assist in determining the most appropriate types of imaging approach and accurate imaging projections for better perform the exam efficiently and safely.

Since J.W. is a non-English-speaking patient, during the communication process, the barriers were encountered because of language difference. The obvious communication barrier between J.W. and us became one of the factors preventing her from cooperating with our instructions, and even ended up avoiding any eye contact with us. We’ve tried implemented multiple strategies to effectively communicate with J.W. Firstly, via simple sentences and words, which might be easier to understand; secondly, speaking every word clearly with gentle voice; thirdly, demonstrated the required positions straight away. Fortunately, the outcome turned out ideal.  The trusting relationship finally established between J.W. and us, and the X-ray examination has done successfully.

Bal (1981) suggested that an overall understanding of the English level of the patient would help medical professionals adapt language accordingly. Aspects listed below are which would be allocable when communicating with non-native English speaking patients:

a. Speak clearly with normal volume.

b. Giving instructions in a clear and logical sequence

c. Do not use medical jargon

d. Longer explanation is usually easier to be accepted thus better not to condense the contents explanation is usually easier to be accepted.

e. Avoid delivering too much information in one session as this may negatively affect the memory while concentrating to understand

f. Ensure patients have full understanding of instructions and given information after each conversation

The lack of English vocabulary required to express the medical symptoms or problems is the obstacle that is very difficult for those who are non-native English speaking patients to overcome (Frank, 2000).

In my future clinical practices, I would take account in all variations of individual patient and adapt specific techniques to achieve the goal of building appropriate interaction with patients, forming effective communications, and professionally performing X-ray examinations. In this special case, I’ve gained valuable experiences from problem solving and adapting specific communicational techniques to successfully conduct the whole examination.

Section 2: “Lead the way”

In medical imaging settings, the role of radiographers is evolving due to globalisation, economic recession, technological advancements, and an increase ageing population (Sithole, 2013). Based on the changing role of radiographers, the concept of leadership must to be emphasized as an essential component which professionals should have to maintain quality and excellence in diagnostic radiography practice. According to Yukl (2002), leadership is the process of facilitating individual and collective efforts to accomplish the shared objectives. ‘’Leader’’ in the medical imaging setting can be defined as the people who have direction, vision, drive and the personal skills that can motivate and lead people in an emotional intelligent manner. A high degree of self-awareness is therefore essential. The leadership of members who at particular position in the medical environments has the required knowledge and skills to lead the department in curricular activity. Furthermore, it is necessary for leaders in DR to assist radiographers to navigate the volatile and complex health care environment. Profession of radiography can thus be ensured by sustainable and effective leadership, which help to face challenges and ongoing changes from the medical environment in the future (Bloom, 2014).

Nerveless, challenges regarding to leadership still encountered in everyday practice within radiography professionals.

An example presented below happened in one of my theatre shifts during my second clinical placement. It associated with the use of leadership power from my clinical supervisor.  In the operating theatre, there was another student who inadvertently touching the surgical equipment which has already been sterilised. The surgical nurse then yowled at the student and rebuked the clinical supervisor. The student was excluded from the whole surgery as the mistake was unacceptable for the whole nursing team. However, at the same time, the supervisor immediately tried to negotiate with the nurse and explained to her that he would take the responsibility of the mistake form the student and ensure everything was well-prepared for the surgery. After the negotiation, the student was allowed to continue the learning process in the theatre. By the end of the day, the supervisor also communicated with the student and let him know what to improve on for the next theatre experience. This example demonstrated the good use of the leadership power from the clinical supervisor to maintain good and open relationship with the student. The supervisor also took the responsibility to properly communicate with the nursing team. Equal relationship between the student, the supervisor, and the nurse was highlighted in this positive leadership example. However, some challenges might be encountered by the leader during the process of achieving successful leadership. This may include having conflicts with other health professionals, students, or patients. Although, the good practical decision-making and effective communication skills was still successfully exhibited in this case.

Section 3: “Reflection time”

A reflective practice activity involves engagement of the practitioners in a continuous cycle of self-observation and self-evaluations in order to critically think and analyse about their own actions and reactions (University College Dublin, n.b.). It’s recognised as a way to learn from our experience as radiographers. The goal of improving on professional practice, observing and refining practice on an ongoing basis can also be accomplishing by participating in reflective practice activities, which allows allied health professionals to identify strengths and weakness accordingly (SARRAH, n.b.).  According to Mantzourani (2019), reflective practice has been linked to distinct characteristics that encourage stimulating evaluation process and hence empower health professionals to achieve better practice.

Keeping a daily reflecting journal can be a good reflecting practice activity for medical imaging professionals. The contents of each journal should be structured into six sections (Gibbs, 1988) :

  1. Description:
  2. Feelings
  3. Evaluations
  4. Analysis
  5. Conclusion
  6. Action plan

For Description and Feelings, the details of the event should be included such as locations, people involved, what activities was proceeding, reasons of happening, contexts of the event, and outcomes. Feelings relating to the process at different stage of the event also need to be specified. It seems similar between the third and fourth part of the journal, which are Evaluation and Analysis. In the section of evaluation, consider both positive and negative parts of the experience. Evaluation and judgement can be made in this section. Proper analysis can be done by breaking the event into smaller components which can be discussed separately and accurately. For conclusion part, try to integrate all the information obtained in previous sections and develop insight into ourselves and other people’s behaviour in terms of how they contributed to the outcome of the event. In the final step of the journal, which is about action plan, it is important to think forward when encounter the similar situation again and to plan what can be done differently or handle the case even better with further knowledge in the future. Reflection and ability to adapt rapid changes in workplace are necessary factors for lifelong learning to occur in medical imaging professions.

To summarise, reflective practice is an essential component in medical practice based on the previous discussion. If reflective practice is performed comprehensively and continuously throughout long term, improved performance and other associated benefits can thus be achieved. Learning from previous experiences and developing own personal skills could be factors leading to a better allied health professional. According to (CAMRT , 2014), successful and continuing professional development can be accompanied via reflective practice. The advantages of reflecting practice are numerous. Enhanced professionalism with greater autonomy and responsibility for future learning. Self-awareness are heightened with the capacity to engage in self-regulation and self-monitoring. The reflective practice activity refers to an ideal approach for medical imaging professionals to work on lifelong objectives or in the future career. The approach facilitates understand and integration of new knowledges, with opportunities to incorporate aptitudes, values, personal beliefs and local professional culture.


References

  • Bloom, R. (2014). Leading the Way in Radiography: Radiography Students’ Perceptions of Leadership in the Field, Leadership Opportunities, and Themselves as Future Leaders.

    Theses and Dissertations (All)

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  • CAMRT . (2014).

    MRTs reflect on their practice to set goals for professional development

    . Retrieved from REFLECTIVE PRACTICE: https://camrt-bpg.ca/professionalism/professional-development/reflective-practice/
  • Dauer, L., Thornton, R., Hay, J., Balter, R., Williamson, M., & Germain, J. (2011, April).
  • Fears, Feelings, and Facts: Interactively Communicating Benefits and Risks of Medical Radiation With Patients. American Journal of Roentgenology, 196, 756-761.
  • Desselleb, S., Lec, J., Lonied, J., Lucasc, C., & Mantzourani, E. (2019). The role of reflective practice in healthcare professions: Next steps for pharmacy education and practice.

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  • Frank, R. (2000, March). Medical communication: non-native English speaking patients and native English speaking professionals. English for Specific Purposes, 31-62.
  • Gibbs, G. (1988).

    Learning by doing: a guide to teaching and learning methods

    . London: Further Education Unit.
  • Lau, L. (2007). Leadership and management in quality radiology.

    Biomed Imaging Interv J, 3

    (3).
  • O’Daniel, M., & Alan H. Rosenstein, A. H. (2008). Professional Communication and Team Collaboration.

    Agency for Healthcare Research and Quality (US)

    .
  • SARRAH. (n.b.).

    Reflective Practice

    . Retrieved from Services for Australian Rural and Remote Allied Health :

    https://sarrah.org.au/content/reflective-practice
  • University College Dublin. (n.b.).

    Defining Reflective Practice

    . Retrieved from Open Educational Resources of UCD Teaching and Learning, University College Dublin: http://www.ucdoer.ie/index.php/Defining_Reflective_Practice
  • Yielder, J. (2006). Leadership and power in medical imaging.

    Radiography

    , 305-313.
  • Yukl G (2002). Leadership in organisations. Upper Saddle River (NJ): Prentice-Hall.

Essay on the Opioid Crisis in the Workplace

Prescription drug abuse has skyrocketed over the past decade, especially from Opioid analgesics, and has become a serious epidemic in today’s society. Despite what some individuals might think this abuse is not only aimed at a small demographic, it could happen throughout all different cultures, upbringings, and occupations, including healthcare. Nurses all over the healthcare spectrum are often working firsthand with these highly addictive medications to provide pain relief to patients under their care. It is essential for the nurse to give adequate patient education to help encourage proper use of the drug and avoid abuse of any kind, whether it is deliberate or not. The position I chose to do my analysis on is “The Occupational Health Nurse’s (OHNs) Role in Addressing the Opioid Crisis in the Workplace” by the American Association of Occupational Health Nurses. The purpose of this position statement is to acknowledge the role nurses have in reducing morbidity and mortality across the nation due to the Opioid crisis by guaranteeing the health and well-being of employees, employers, and their families are protected as well as their workplace (OHN, 2018).

This topic has become more significant and relevant to patient care throughout recent years. “In 2017, more than 70,000 people died from drug overdoses, making it a leading cause of injury-related death in the United States and of those deaths, almost 68% involved prescription or illicit Opioid” (CDC, 2019). Providers prescribe Opioids with the hopes of relieving severe pain for acute and chronic work or non-work-related injuries and may be very helpful if taken as directed, but they are often abused which can lead to a very serious addiction. Even if taken properly, it could potentially result in an injury at work, a decrease in job efficiency, or worse. Shockingly, the majority of heroin users have admitted the reason they got into the hard drug started from taking pills legally prescribed by their doctor. This shows that it is not just people on the streets that are dying of this disease, but it also can affect your average American worker trying to make a decent living. It is now more important than ever for workplaces to implement policies to help combat this issue internally as well as healthcare workers providing in-depth education. Employees who are prescribed Opioids need education on how to follow directions on the label correctly, the seriousness of never sharing prescriptions with other people, how to safely store the medication, and how to recognize potential interactions with other drugs and alcohol. The workplace should also look out for employees who seem to be extra drowsy or in a euphoric state because it can sometimes be hard to spot someone who is using and the side effects of Opioid use can lead to workplace injury.

This topic is also relevant to nursing practice because nurses can play a significant part in decreasing this epidemic by effectively assessing, monitoring, and educating patients. The nurse can do a lot of things to help prevent addiction when taking care of a patient who is prescribed Opioids. The first thing a nurse can do is get a detailed history of the patient’s health including the history of patient and family substance abuse as well as a list of past and currently prescribed medications. To assess for signs and symptoms of substance abuse, a thorough psychiatric and physical examination should be performed and anything out of the ordinary should be passed on to the provider. Nurses should also try different approaches to provide pain relief to patients, including non-pharmacological approaches, before going straight to the narcotics. Finally, when discharging a patient the nurse needs to educate them with verbal and written instructions on everything they need to know about the drug and why they are taking it, including alternative options the patient can try.

This position statement starts by giving examples of challenges at the workplace related to Opioid abuse that not only cause employees to be exposed to serious risks but that also can cost the company a lot of money. The statement then discussed in detail why it has become such an issue, and what is being done to elicit change from various organizations through raising awareness and acknowledging the potential for substance abuse. After listing some strategies that have been implemented, they came to the conclusion that a multi-faceted strategy is needed to decrease Opioid morbidity and mortality through the active involvement of occupational health nurses. The position statement then provides examples of how occupational health nurses work with employers to help prevent Opioid related work injuries or addictions (OHN, 2018).  It also includes adequate nursing education from occupational health nurses, workers, and management. Finally, the position statement finishes with a conclusion as to what they are aiming to accomplish and why they think that occupational health nurses are well-placed to lead the battle against Opioid dependence.

Due to the rising epidemic of Opioid abuse, this position statement has had a big impact on professional practice. Many organizations have raised awareness of this topic over the past decade and have made it known that prescription drugs are very dangerous and have many serious and deadly side effects. The American Association of Occupational Health Nurses has worked with employers to change policies by reviewing old drug testing policies and improving them by including synthetic and non-synthetic Opioid screening. They also have provided strategies for improving and standardizing Opioid prescriber training across health care provider groups to include other pain management options, how to discuss realistic pain management goals and what to expect realistically once treatment is complete, how to recognize potential risks and side effects, how to properly screening for abuse and co-morbidities, and how to facilitate referrals for treatment and recovery (OHN, 2018).

This position statement did a very good job going over strategies that have been addressed related to the Opioid crisis in the workplace as well as providing approaches implemented by occupational health nurses and employers. However, I believe this strategy could be somewhat tweaked to make it more relevant to a practitioner or registered nurse in a hospital setting. Before it even reaches the workplace, I believe health care providers can be executing all of these things before the patient is even discharged from the hospital. I also think that physicians should be more cautious when prescribing Opioids and seeking alternative ways to effectively reduce the patient’s pain.

While it is unrealistic to expect that the misuse of prescribed pain medication in the workplace will totally disappear, occupational health nurses are confident in their ability to help decrease the prevalence of their reliance across the nation. These nurses are able to provide individualized employee education, provide staff with confidentiality to build trust and have a mutual understanding, enhance drug testing, and partnering with other organizations to address this issue from all angles. Overall, I believe this position statement was significant and relevant to patient care and nursing practice and definitely could be implemented in a more relevant acute health care setting that we are used to seeing.


References

  • American Association of Occupational Health Nurses (2018). The Occupational Health Nurse’s (OHNs) Role in Addressing the Opioid Crisis in the Workplace
  • Opioid Overdose | Drug Overdose | CDC Injury Center. (0AD). Retrieved from https://www.cdc.gov/drugoverdose/index.html

The Future of Cancer Treatment


ABSTRACT

Cancer comprises several diseases that are characterized by abnormal cell growth. There are over one hundred varieties of cancer usually named for their cell or organ type. Cancer is the root cause of death across the world evidenced by WHO which established that around one in six deaths all over the world are due to cancer. The common cancer treatments currently used include surgery, chemotherapy, and radiation; which on some level are harmful to the healthy body cells and also the cancerous cells. Nevertheless, none of these treatments completely guarantees that the cancer cells are bound to stop multiplying and dividing. However, some chemotherapy radiation and drugs do slow or assist in stopping the cancer cell reproduction, while on the other hand surgery works at removing all the cancer cells from the body. As such, these poses need for doing research to get cancer cure as well as improve the outcome for the patients affected by the disease. Nevertheless, as much as focus is given on cure, it is important to educate the public on ways of preventing cancer by observing diets and changing lifestyles. People should also be constantly screened for various types of cancer since early identification increases possibilities of cure.

 


INTRODUCTION

Cancer comprises several diseases that are characterized by abnormal cell growth. These cells can attack various tissues of the body, which results in serious health issues. Cancer cells can spread to other body parts via the lymph and blood systems. Davila et al. (2010) ascertained that there over one hundred varieties of cancer usually named for their cell or organ type. Currently, cancer is the root cause of death across the world. The World Health Organization (WHO) noted that all over the world, around one in six deaths are down to cancer. The National Cancer Institute (NCI) in 2017 estimated that only in the US, one million, six hundred and sixty six thousand, seven hundred and eighty new cancer cases are reported and six hundred thousand, nine hundred and twenty deaths are cancer-related (Roser and Ritchie (2019).


Statement of the problem

Research conducted by Roser and Ritchie (2019) shows the need for getting cancer cure in order to improve outcome for the patients affected by the disease. Their findings reveal that WHO, healthcare planners, National Cancer Institute, International Agency for Research and European Cancer Organization are working towards getting cancer cure. The main objectives of this research are: to determine various ways of preventing, identifying and treating cancer and to find out the reason why it is difficult to get cancer cure.


Purpose of the Study

The researcher herein sought to acquire comprehensive knowledge in cancer causes, identification methods as well as treatment methods.


Research problem

The study addresses a research problem or issues pertaining cancer cure and related ways of making treatment easy and possible.


Research questions

To cover the research gaps identified, the following research questions were found to be relevant:

  1. Why is it difficult to get cancer cure?
  2. What are the various ways of preventing cancer as well as making cure possible?
  3. What are cancer treatment methods currently used and how are they improved to effectively cure cancer?


LITERATURE REVIEW


Immunotherapy

Cancer immunotherapy is a type of cancer treatment method that assists the immune system in fighting the cancer cells. The immune system consists of range of cells, organs, and tissues that assist the body in fighting off the foreign invaders, which includes the parasites, bacteria, and viruses (Sharma, Hu-Lieskovan, Wargo, & Ribas, 2017). However, since cancer cells are not foreign invaders, the immune system may require some help in identifying them. Various researchers have identified various ways of offering this help (Roser & Ritchie, 2019).


Boosting the immune system’s ‘arsenal’

Immunotherapy is one of the therapies that has recently attracted a lot of attention. Immunotherapy targets at reinforcing our own bodies’ subsisting arsenal against harmful cells and foreign bodies: the body immune system’s reaction to the multiplication of the cancer tumors. However, various types of cancer cells are so dangerous since they have means of “duping” the immune system by either providing them with a “helping hand” or else ignoring them altogether. As such, some forms of aggressive cancer can possibly spread more easily and be resistant to radiotherapy and chemotherapy (Fukuhara et al., 2016).

Nonetheless, Vitro and in vivo experiments gives new hope whereby the researchers are learning of various ways on how to ‘deactivate” the cancer cells’ protective systems. Roser and Ritchie, (2019) in their research established that the white blood cells are usually assigned with “eating up” cellular debris and additional dangerous foreign “objects that fail to wipe out the super-aggressive cancer cells (Stivarou,  Stellas, Vartzi, Thomaidou, & Patsavoudi, 2016). This was because, in the course of interacting with the cancer cells, the white blood cells read not only one but two signals that are intended to fight off their “cleansing” action. This knowledge has unlighted the scientist on the best mechanism of fighting the cancer cells by blocking the two important signaling pathways; they re-enable the white blood cells to do their task.


Therapeutic viruses and innovative “vaccines”

Therapeutic viruses’ acts as a surprising weapon meant to fight against cancer. This technique involves a strain of reovirus only to kill brain cancer cells while not affecting the healthy cells in any way. El Mjiyad, Caro-Maldonado, Ramirez-Peinado and Munoz-Pinedo (2011) identified that therapeutic virus has the capacity to cross the brain-blood barrier hence opening up the chances of this type of immunotherapy to be utilized in treating individuals with aggressive brain cancers (Fukuhara et al., 2016).

El Mjiyad et al. (2011) identified “dendritic vaccines” as another sector of improvement in immunotherapy. In this strategy, the dendritic cells are taken from an individual’s body, “armed” with tumor-particular antigens meant to teach them on how to “hunt” and kill relevant cancer cells and introduced back into the body for purposes of boosting the immune system.

Klebanoff, Acquavella, Yu, and Restifo (2011) pointed out that Switzerland’s researchers have identified a way of improving dendritic vaccine action by forming artificial receptors that are in a position to recognize as well as “abduct” small vesicles that are related to cancer tumors’ distributed in the body. Through the attachment of the artificial receptors to the dendritic cells in the “vaccine,” the therapeutic cells are enhanced to accurately identify the harmful cancer cells.

El Mjiyad et al. (2011) in their recent studies identified that immunotherapy could work best if offered in a cycle with chemotherapy and more precisely in cases where chemotherapy drugs are first administered then immunotherapy follows. However, Fukuhara et al. (2016) identified some setbacks in this combined method by posing difficulties in controlling the effects such that sometimes the healthy tissues are attacked together with the cancer cells. Luckily, North Carolina’s scientists from two institutes developed a substance that immediately introduced into the body; it turns into a gel-like “a bioresponsive scaffold system (Dine, Gordon, Shames, Kasler, & Barton-Burke, 2017).” The scaffold has the ability to hold both the immunotherapy and chemotherapy drugs at the same time, discharging them into primary tumors. This method enhances better regulation of both therapies, making sure that the drugs only responds to the targeted tumors only.


The nanoparticle revolution

This tool has garnered so much attention in clinical research amongst other various researches since it accurately and efficiently delivers drugs directly to the tumor as well as destroying the micro tumors. The nanoparticles have the ability to target the cancer tumors or the cells without necessarily damaging the healthy body cells in the surrounding surroundings (Brannon & Hadjifrangiskou, 2016).

Some of the nanoparticles are formed in a way that they offer a much focused hyperthermic treatment, a therapy that utilizes hot temperatures to cause the cancer cells to shrink. In 2017, the UK and China scientists established a type of “self-regulating” nanoparticle that successfully exposed cancer tumors to heat without touching the healthy tissues (Pinank, Kaushik, Shyam, Amrutia, & Faldu, 2016).

Pinank et al. (2016) identified that nanoparticles can also be utilized to target cancer stem-like cells, which are associated to the resilience to specific forms of cancer in the facade of traditional cancer treatment, for instance, the chemotherapy. Additionally, the nanoparticles can also be “loaded” with drug and placed to kill the cancer stem cells in order to hinder the growth reappearance of the tumor. This has been tested and found to effectively treat endometrial and breast cancer. Moreover, the “nanoprobes” which are used in detecting the presence of micrometastases, which previously could not be identified by the use of traditional methods (Fukuhara et al., 2016).


Tumor “starvation approaches

Researchers are currently focusing on this strategy, whereby the tumors are starved of the nutrients that they require to grow and spread. Fukuhara et al. (2016) pointed out that this would work out best in case of the cancers that are resilient and aggressive and cannot be successfully eradicated otherwise. Tam et al. (2010) identified “stopping glutamine” from supplying nutrients to the cancer cells as the best strategy to eradicate cancer especially the colon, breast and the lung cancer which are widely known to utilize amino acid to support their growth. Once the cancer cells are blocked from access to glutamine, they tend to die via the oxidative stress. Blocking access to vitamin B-2 has been identified by researchers from the University of Salford in the U.K as an effective way of depleting the cancer cells of energy.


METHODOLOGY

In this research, a qualitative research methodology was adopted.  The main interest in this qualitative research was to find relevant articles that could establish whether there is a probable future in which cancer could get a treatment.  Since cancer affects all populations, the research was not restricted to a certain population in a society. Therefore, data involving diversified population but relevant to the research question was utilized.

The researcher scoured the internet through different databases to find the most recent peer-reviewed articles. This was critical in responding to the research gap established in the literature review. The databases that the researcher found to be relevant for inclusion included Google Scholar, PubMed, CINAHL, Cochrane Library, and TOXNET. In the databases, the search was limited to articles published in the last 10 years. However, articles published in the last five years were prioritized. Key phrases such as cancer treatment, the future of cancer cure, treatment for all cancers, discoveries in cancer treatment among others were utilized. After the articles were found, the researcher read the abstract of each article and articles that had relevant information were recorded.

Thematic analysis was conducted to come up with the key themes regarding the future in cancer treatment. In thematic analysis, the research involved reviewing the findings of all articles found fit for inclusion to come up with the common ideas regarding the future of cancer treatment.


RESULTS

The table below summarizes the total articles found from each database.

Database Total articles Articles Excluded Articles included
Google Scholar 40 38 2
PubMed 16 15 1
CINAHL 14 11 3
Cochrane Library 6 5 1
TOXNET 7 7 0


DISCUSSION


Current Cancer Treatment

Currently, cancer is the root cause of death across the world. The common cancer treatments currently used include surgery, chemotherapy, and radiation; which on some level are harmful to the healthy body cells and also the cancerous cells. They all stop cancer cells at one point from multiplying by use of hyperthermia, drugs, photodynamic therapy, stem cell/bone marrow transplant, cryotherapy, gene therapy, radiation therapy, immunotherapy and surgery amongst others (Dine et al., 2017). Nevertheless, none of these treatments that completely guarantees that the cancer cells are bound to stop multiplying and dividing though some chemotherapy radiation and drugs do slow or assist in stopping the cancer cell reproduction while on the other hand surgery works at removing all the cancer cells from the body. Cancer that is untreated can result in serious illness or death (Roser & Ritchie, 2019).


Cancer Treatment Innovations

Cancer treatment innovation targets at addressing a set of issues that typically faces healthcare patients and providers, which includes aggressive treatment combined with unwanted side effects, tumor reappearance after surgery, treatment or both and destructive cancers that are hardy to widely used treatments. Use of surgery, medicine, radiation, and modification of the immune system are in the track of finding more ways of curing some cancer patients (Dine et al., 2017). On the other hand, some types of cancer will have new approaches that may not completely eliminate or rather cure cancer but will effectively manage cancer increasing the life span of the cancer patients as well as give them chance to enjoy life without the major cancer consequences. This can only be achieved via a specialist’s continued support who dedicates their lives towards enhancing care and outcome for the cancer patients.

A number of less widespread cancer treatments existing have the capacity to be more effective, with minimal side effects than the most normally known treatment. Continuation of research on these treatments is crucial to continue to improve them. Nevertheless, other types of cancer treatment are cropping up to pick up the steam; therapies that work independently or in combination with others are intended to assist in defeating cancer more efficiently and idyllically with minimal side effects.


Complexity of Cancer Treatment

For quite some time now, researchers have led scrupulous studies that focus on ways of stopping this deadly disease in its track. There are various types of cancer treatments, and the type of treatment offered to the patient depends on the cancer type and how advanced it is. Some cancer patients undergo one treatment while others have a blend of treatments (Roser & Ritchie, 2019).

Considering the fact that cancer is not just one disease but a collection of several complex and normally very dissimilar illnesses; that aim the body in a heap of various ways and are found at different stages, there is no single cure. However, there are various ways that can readily improve the cancer situation, and more research will undoubtedly bring more hope to cancer cure. Advancement in cancer treatment has resulted in more modest development in survival and outcome (Roser & Ritchie, 2019).


Ways of Preventing Cancer Which Enhances Cure

Roser and Ritchie (2019) pointed out that 40% of cancers are preventable via changing lifestyles such as avoiding drinking, consuming less alcohol as well as maintaining a healthy weight. The remaining sixty percent results from environmental factors that are not well known. Genetic factors also cause various types of cancer which occur by chance. As such, identification of the mechanisms that underpins cancer causes, it would be easy to prevent as well as cure cancer. Moreover, it has been proven that early identification of cancer makes it easy to manage or else cure it. Early identification of cancer can be achieved through cancer check-up in the general population to ensure that it is detected at early stages before symptoms show up and before it becomes difficult to treat it. During tests, doctors need to be accurate enough to ensure that they do not give false results in healthy individuals to ensure that people are not treated for cancer that they do not have. Additionally, they need to also accurately identify the exact part of the body with cancer cells in order to have the right treatment administered (Dine et al., 2017). Even though it is not possible to prevent all types of cancer, it is crucial to work towards reducing the burden of cancer (Davila et al., 2010).


Conclusion

Cancer research is currently taking place at a very high speed; the researchers are taking full advantage of all technological progress that science has realized over the recent years. The issue of getting a cancer cure is somehow tricky since cancer types vary immensely. However, promising studies have been published that gives hope for a more effective treatment for most cancer types though they are in their early stages. This makes it almost impossible to conclude that a strategy that works best for one cancer type can be possibly adapted for all. It is also important to note that some potential cancer treatments require more time before clinical trials can be undertaken in human patients. However, this should never discourage people in any way, but instead, the scientist’s efforts should make people optimistic. But in reality, we are not at a stage where we can confidently claim that cancer can be easily eliminated. Nevertheless, our furthered information and the more precise tools at the scientist exposure keep them ahead of the game, which improves odds in eradicating it.


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