Evidence Based Practice in Nursing Essay

Introduction

Evidence based practice is a complex experience that requires synthesizing study findings to establish the best research evidence and correlate ideas to form a body of empirical knowledge (Burns & Grove 2007). There are many definitions but the most commonly used is Sackett et al (1996). Sackett et al (1996) as cited in Pearson, Field, & Jordon, (2007) describes evidence based practice:

“the conscientious, explicit and judicious use of current best available evidence in making decisions about the care of individual patients. The practice of evidence based medicine means integrating individual clinical experience with the best available external evidence from systematic research”. (Sackett et al 1996 page 5).

The author will discuss the importance of evidence for practice, different types and levels of evidence. The research process, dissemination of evidence, barriers and will conduct a critique of two research articles.

The importance of evidence based practice is to enable nurses to provide high quality care, improve outcomes for patient and families and to run a more efficient health service. Therefore other agencies within the health service will benefit when interventions and care is based on research (Burns & Grove 2007). According to the Nursing and Midwifery Council (NMC) code nurses are accountable to society to provide a high quality of care so therefore it is important that nurses reflect, evaluate the care and keep abreast of new knowledge and evidence that is available (Burns & Grove 2007). Providing a streamlined service, which is cost effective and based on current evidence based practice has shown to reduce cost but also to enhances the quality of care the patient receives (Melnyk et al2010). Working in partnership with the nurse the patient is able to participate in decisions about their care. This is not only beneficial for the patient but also increases the satisfaction of the nurse treating the patient (Craig & Smyth 2007). Furthermore Craig & Smyth (2007) suggests evidence based practice is a problem-solving approach to the delivery of health care. In using a problem solving approach the nurse is able to integrate clinician expertise and patient preferences to provide individualized care suitable for the patient.

To acquire knowledge in the past, nurses have relied on decisions based on trail or error, personal experience, tradition and ritual. Parahoo (2006) suggests learning by tradition and ritual are important means of transferring knowledge, for example learning the ward routine. According to Brooker and Waugh (2007) Students learn from effective colleagues who practice safety and on the basis of best evidence. However, a disadvantage of this method of learning may lead to transmission of invalid information and may put the patient and nurse at risk (Brooker & Waugh 2007). According to Burns and Grove (2007) to generate knowledge a variety of research methods are needed. The two different research methods are quantitative and qualitative. According to Burns and Grove (2007) quantitative research is an objective formal systematic process and demonstrates its findings in numerical data. According Munhall (2001) qualitative research is gathering information to describe life experiences through a systematic and subjective approach and does not use figures or statistics to produce findings. In nursing practice the quantitative approach has been considered to provide stronger evidence than qualitative (Pearson, Field, & Jordon, 2007). Pearson, Field, & Jordon (2007) suggest health professionals and servicer users require a variety of information to facilitate change and to include evidence not only of effectiveness but feasibility, appropriateness and meaningfulness to achieve evidence based health care practice.

Evidence based practice promotes the application of research evidence as a basis on which to make health care decisions so it is important to search for the truth and knowledge logically. Robust research which may draw on expertise and experience represent a higher level of evidence because of the discipline involved (Burns &Grove 2007). There are thirteen steps in the quantitative research process and one step gradually builds on another (Burns & Grove2007). The beginning of the research process starts with a problem which usually highlights a gap in knowledge (Melnyk & Fine-Overholt 2005). The next step is the purpose of the research. This is produced from the problem and identifies the aim of the study (Burns & Grove2007). To build a picture up of what is known or not known about the problem a literature review is conducted. This will provide current theoretical and scientific knowledge about the problem and highlight gaps in the knowledge base (Burns & Grove 2007). This is followed by the study framework and research objectives, questions and hypotheses. This continues to the end till all the steps are covered. The final step is the research outcome.

Hierarchy of evidence is generated from the quality of information from different evidence. Practitioners are able to use the hierarchy of evidence to inform them on which information is most likely to have the maximum impact on clinical decisions (Leach 2006). Leach (2006) suggests hierarchy of evidence may be used to discover research findings that supersede and invalidate earlier accepted treatments and change them with interventions that are safer, efficient and cost-effective. If findings from a controlled trial are inadequate, choices should be guided by the next best available evidence (Leach 2006).

According to Scottish Intercollegiate Guidelines Network (SIGN 2009) the revised grading system is planned to place greater weight on the quality of the evidence supporting each recommendation, and to highlight that the body of evidence should be considered as a whole, and not rely on a single study to support each recommendation. The grading system currently in use with the SIGN guidelines starts with 1++ and ends in 4. For the evidence to be rated at 1++ it must include a high quality meta-analyses, systematic reviews of random controlled trails (RCT) or RCT with a low risk of bias. Level 4 is based on expert opinion (SIGN 2009).

There are many barriers to implementing evidence based practice. One of the common barriers is staff information and skill deficit. Health professionals lack of knowledge in regarding results of clinical research or current recommendations may not have the sufficient technical training skill or expertise to implement change (Pearson, Field, & Jordon 2007). Nurses have also highlighted lack of time as a barrier in applying research to practice. As the number of patients increases nurses face the challenge of providing safe, high-quality care within a short time frame. Nurse educators and researchers have developed a “toolkit” to ease the implementation of evidence based practice into nursing (Smith, Donez & Maghiaro 2007).

According to Gerrish and Lacey (2006) dissemination is a process of informing people about the results of a particular research. There are many ways to present results, video, seminars and the most accepted is through professional journals. However with the internet being more assessable the researcher is able to post details on the website hosted by NHS trust or university. One disadvantage in using the internet is that it provides no guarantee of quality (Gerrish & Lacey 2006). SIGN guidelines are circulated free of charge throughout Nation Health Service (NHS) Scotland. For this to happen they must be made widely available as soon as possible to facilitate implementation. Furthermore guidelines on their own have proved ineffective and more likely if they are disseminated by active educational intervention and implemented by patient-specific reminders relating directly to professional activity (SIGN 2009).

Critique 1

Rydstrom I, Dalheim-Englund A, Holritz-Rasmussen B, Moller C, Sandman P-O (2005). Asthma – quality of life for Swedish children.Journal of Clinical Nursing 14, 739-749. Blackwell Publishing Ltd.

As the title suggests this was a research to find out how Swedish children with asthma experience their quality of life and to look for potential links between their experience of quality of life and some determinants. This study was accomplished by using a quantitative research approach which adhered to the aims and objectives. Quantitative research is formal, objective, systematic inquiry that involves numerical data (Burns & Grove 2007). The two stages used in the quantitative research were correlation and quasi-experimental (Burns & Grove 2007). This is an acceptable method to use as the study was trying to explore the relationship between two variables and the findings were produced in a numerical format.

In previous literature it was noted investigations in children with asthma around the world all had similar experiences (Rydstrom et al2005).It also highlighted that girls and boys perceived asthma in a different way and girls were more likely to include asthma in their social and personal identities where boys would exclude the condition (Williams 2000). The researchers wanted to ask the children how they experience their life living with asthma. Also to look at possible links between children’s quality of life and determinants such as age, sex, pets, siblings, location and social status (Rydstrom et.al. 2005).

Some common types of sampling used in quantitative research are random and non-random samples (Burns and Grove 2007). In the article for the purpose of this study all hospitals and clinics were used and fifteen were chosen randomly for the study (Rydstrom et al2005). Both children and parents were asked to participate in the study but children had to meet the inclusion criteria before being selected (Rydstrom et al2005). By using a random sample the general population becomes representative of the larger whole (Parahoo 2006).

Validity was established by cross-matching Paediatric Asthma Quality of life Questionnaire (PAQLQ) with About my Asthma (AMA), by Mishoe et.al.(1998). Warschburger (1998) recommended that PAQLQ was a reliable instrument and Reichenberg & Brogerg (2000) found that there was no difference concerning reliability between the Swedish and the original PAQLQ.

The study was approved by The Ethics Committee at the Medical Faculty of Umea University in Sweden and consent was received from parents and children. Burns and Grove (2007) define sampling as a process of selecting groups of people who are representative of the population.

Data was collected through self administration questionnaires. There advantages and disadvantages in using questionnaires. Advantage firstly, the data is gathered is standardised and therefore easy to analyse. Secondly, respondents can answer anonymously which may produce more honest answers. A disadvantage is the responses may be inaccurate especially through misinterpretation of questions in self completing questionnaires. (Gerrish & Lacey 2006). Children age seven to seventeen were required to fill in Paediatric Asthma Quality of life Questionnaire (PAQLQ) which was used to measure the children’s quality of life in different domains. Parents were required to fill in Paediatric Asthma Caregivers Quality of life Questionnaire (PACQLQ) (Rydstrom et al2005). Children and parents filled in questionnaires separately and a nurse was on hand to help children who could not manage on their own.

The researchers clearly identify what statistical tests were undertaken. However the results are presented in a complex manner. The results showed the majority of children estimated their quality of life at the positive end of the scale. Children reported impairment in the domain of activities than emotions and symptoms for example not being able to run around. Living in the south of Sweden and being a boy were reported to have a better quality of life. Furthermore children living with a Mum over forty or with cohabiting parents had a better quality of life (Rydstrom et al2005).

The researchers brought to the attention of the reader the laminations within the study. Children view friends and their social environment being important to them however there were no questions relating to this and also it did not take into consideration the child’s stage of development (Rydstrom et al2005). Also the research was done within a week, therefore would the results be different if it was done over a longer period. This was not a controlled research so there is a possibility that some data may be missing as nobody was checking to see if the children had filled in all the questions.

The findings highlight it is important for the nurse to look at all aspects of the child development. Furthermore caring tends to focus on the patients’ limitations, another important issue for nurses is to try to discover those aspects in a child’s daily life that contribute to a high QoL in order to improve and maintain the child’s wellbeing.

Critique 2

Lyte, Milnes, Keating & Finke 2007. Review management for children with asthma in primary care: a qualitative case study.Journal of Nursing and Healthcare of Chronic Illness in association with Journal of Clinical Nursing 16, 7b, pp123-132

As the title suggests this research article will focus on review management for children with asthma within a primary care setting. This study was accomplished by using a qualitative case study design. In using a qualitative case study design it can provide much more comprehensive information than what is available through other methods, such as surveys (Neale, Thapa & Boyce 2006). Neale, Thapa & Boyce (2006) suggest case studies also allow one to present data collected from multiple methods (i.e., surveys, interviews, document review, and observation) to provide the complete story. Qualitative research is systematic, subjective approach (Burns & Grove 2007) which describes life experiences, meanings, practices and views of those involved (Craig & Smyth 2007).

In the UK one in eight children suffers from the effects of asthma and the majority of cases are now being managed in the primary care setting (National Asthma Campaign 2001). With improvement in management of asthma over the years there is still a high level of morbidity and mortality (Lyte et al2005). Out of Sight, Out of Mind (Asthma UK 2005) agrees with Lyte et al(2005) that death rates are high. In Scotland the death rates due to asthma vary each year. Furthermore inquires have shown at least 90% of those deaths could have been avoided. However child admissions to hospital due to asthma have fallen slightly (Out of Sight, Out of Mind Asthma UK 2005). Furthermore it was highlighted through a systematic review of literature published at the time of research that it was unknown whether primary care based asthma clinics were effective. Additionally it concluded that patients’ views on asthma clinics were also unknown (Fay et al2003). One cannot ignore the fact that there are evident gaps in generic knowledge of primary care asthma services for children in the UK (Lyte et al2005). Therefore the aim of the study is to investigate current review management of children’s asthma in one primary care trust and to consider the views of children, their parents/carers and the role of the practice nurse in asthma care in one primary care trust (Lyte et al2005).

For the purpose of this research Lyte et al(2005) used purposive sampling to gather information. Craig & Smyth (2007) suggests there are various methods can be applied to data collection. Lyte et al(2005) used interviews, observations and reviews of available documentation regarding asthma (Artefactual). In using this type of sampling the researchers can be specific on the groups they wanted to target. However they may be an element of bias as the practice nurse selected the parents and children for this research. To strengthen the research the researchers used triangulated methods for data collection. According to Craig & Smyth (2007) the theory behind triangulation if multiple sources, methods, investigators or theories provide similar findings their creditability is strengthened.

The study was approved by the Local Research Ethics Committee and the University’s Senate Ethics Committee. Throughout the research during the data collection consent was treated as an ongoing process. However there was difficulty in communicating with children. To solve this problem, when meeting with the children the researchers would go through the informed consent and voluntary participation again. Confidentially of all participants were protected and guaranteed by the Data Protection Act.

Children expressed a wish to participate and share information in the research (Lyte et al 2005). However some children felt through the research of not being involved. Lyte et al (2005) suggested it is the child’s personality that determines how much response the practice nurse receives. It is often said good communication in nursing is crucial and is the foundation of building trust and encourages children to seek advice. It is important to communicate with children appropriately to match the stage of development (The Common Core of Skills & Knowledge 2010). Ultimately effective communication allows for the exchange of information, needs and preferences of the patient between herself and the patient (The Common Core of Skills & Knowledge 2010). However Hobbs (1995) suggests that some practice nurses may not have the training in regarding complexities of caring for children and their families. One cannot deny that it is important for practitioners to have the appropriate training (Alderson 2000) because children have equal rights to contribute to their care as well as adults (Save the Children 1997).

It was noted that children did not have sufficient knowledge about asthma. Furthermore parents and children highlighted that there was insufficient information on asthma in the primary care setting. For children and adults to make informed choices regarding their asthma they require having up to date information to help them in making decisions. Equally in one practice it was identify that the practice nurse lack confidence in caring for children with asthma and Hobbs (1995) confirms this lack of confidence and points out that practice nurses deal with arrange of illnesses.

Parents and children in the study both agreed that one area for improvement was the waiting room (Lyte 2005). Some children may find going to the doctor a very frightening experience. The first expression needs to be reassuring and non-threatening. (Making Your Waiting Room Kid-Friendly 2006). The waiting room should be child friendly and also have books, television/video for older children. With today’s technology many children use computers in the classroom. Some computer programs are touch-screen driven, making them friendly to all levels. Providing a computer in the waiting room may be ideal opportunity to encourage children to show off their technical skills by accessing the computer for health-related information (Making Your Waiting Room Kid-Friendly 2006).

It might be concluded from this research the strengths outweigh the weaknesses, despite the research being conducted in one primary care trust. The most satisfactory conclusion that can come from this, to facilitate children and parents a comprehensive package of care needs to be put in place in order to manage their asthma effectively.

References

Burns N, Grove S, (2007). Understand Nursing Research, Building an Evidence-BasedPractice. Fourth Ed

Craig J V, Smyth R L (eds). (2007). The Evidence-Based Practice Manual for Nurses. China: Churchhill Livingstone Elsevier.

Leach M J (2006). Evidence -based practice: A framework for clinical practice and research design. International Journal of Nursing Practice. 12, pp 248-251

Lyte, Milnes, Keating & Finke 2007. Review management for children with asthma in primary care: a qualitative case study.Journal of Nursing and Healthcare of Chronic Illness in association with Journal of Clinical Nursing 16, 7b, pp123-132

Melnyk, Mazurek , Fineout-Overholt, Ellen, Stillwell, Susan, Williamson, (2010). Evidence-Based Practice: Step by Step: The Seven Steps of Evidence-Based Practice. AJN, American Journal of Nursing: January 2010 – Volume 110 – Issue 1 – pp 51-53

Mishoe SC, Baker RR, Poole S, Harrell LM, Arrant CB & Rupp NT (1998). Development of an instrument to assess stress levels and quality of life in children with asthma.Journal of Asthma 35, 553-563.

Munhal (2001) cited in Burns N, Grove S, (2007). Understand Nursing Research, Building an Evidence-BasedPractice. Fourth Ed

Questionnaires – a brief introduction [online]. (2006) [Accessed 15th March]. Available from:



.

Reichenberg K & Broberg AG (2000) Quality of life in childhood asthma: use of the paediatric Asthma Quality of Life Questionnaire in a Swedish sample of children 7-9 yearsold. Acta Paediatrica 89, 989-995.

Roberts P et al(2006). Reliability and Validity in research. Nursing Standard. 20,44, 41-45

Rydstrom I, Dalheim-Englund A, Holritz-Rasmussen B, Moller C, Sandman P, (2004). Asthma – quality of life for Swedish children. Journal of Clinical Nursing, 14, pp739-749.

Sackett et al (1996) pp 5 cited in Pearson A, Field J, Jordan Z (eds). (2007). Evidence-Based Clinical Practice in Nursing and Health Care. Singapore: Blackwell Publishing.

Williams (2000) cited in Rydstrom I, Dalheim-Englund A, Holritz-Rasmussen B, Moller C, Sandman P, (2004). Asthma – quality of life for Swedish children. Journal of Clinical Nursing, 14, pp739-749.

Warschburger P (1998) Measuring the quality of life of children and adolescents with asthma – The pediatric asthma quality of life questionnaire.Rehabilitation 37, XVII-XXIII.

Advanced breast cancer

Background

Cancer accounts for 13% of all deaths in 2007, making it the largest cause of mortality worldwide and is the leading cause of premature death in Scotland. 2,22 Out of the staggering figure of 27,500 new cases that were diagnosed on that same year in Scotland, 4044 of them are breast cancer cases, making breast cancer the most commonly diagnosed cancer among Scottish women.3 In the UK, 16-20% of women have advanced breast cancer and approximately 40-50% of those diagnosed with early or localised breast cancer may eventually develop metastatic disease. Breast cancer is usually defined using a staging system known as the Tumour, Node and Metastasis Staging System (TNM) and stage III and IV are known as advanced stages of the disease with stage III being locally advanced and or has spread to regional lymph nodes and stage IV describing the presence of metastases at distant sites such as the bone, brain, or lung.23

In the elderly group of female cancer patients, the prevalence of breast cancer is highest at 4% and these post-menopausal women make up 80% of all breast cancer patients, hence proving that the risk increases with age.1 Apart from age, other factors like family history, uninterrupted oestrogen exposure, early menarche, late menopause, late first pregnancy, hormone replacement therapy, obesity, not breast feeding, taking oral contraceptives and past breast cancer may all attribute to a higher risk of developing breast cancer.9 Over the last decade, mortality rates from breast cancer have dropped by almost 14%, despite having more women diagnosed with the disease. In 2000-2004, the survival rate for breast cancer patients has also bumped up to 84% compared to a mere 64% 20 years earlier.4Improvement in prognosis, screening techniques such as mammography, ultrasound and Magnetic Resonance Imaging(MRI), earlier diagnosis of cancers in women participating in the Scottish Breast Screening Programme, a myriad of new hormonal and chemotherapy treatments, and better organisation and patient care plans has attributed to the substantial increase in incidence and survival rate of breast cancer patients.

Women today are also encouraged to perform self breast examinations, hence are familiar with the shape and feel of their breasts, as well as to look out for abnormities like a new discrete lump, nipple discharge, unilateral persistent pain especially in post-menopausal women or pain associated with a lump and skin changes comprising of skin tethering, ulceration, abscess or inflammation.However, there is still a disparity between women from different social classes in terms of combating this disease. Women from more affluent backgrounds are more likely to have their breast cancer diagnosed earlier, have slower disease progression from the time of diagnoses and higher survival rates compared to women from poorer socioeconomic backgrounds. Women from more deprived communities are more likely to be diagnosed with the advanced stage of the disease.

Pathogenesis

Cancer or malignant neoplasm which literally means new growth is a disease manifested in the form of uncontrolled cell proliferations, dedifferentiation and loss of function, invasiveness and metastasis.6 Breast cancer usually forms from the inner lining of milk ducts or the lobules that supply the ducts with milk. In patients with Breast Cancer, women who inherit a single defective copy of tumour suppressor genes BRCA1 or BRCA 2 have a marked higher risk of developing breast cancer in their lifetime. The presence of a defective BRCA1 or BRCA 2 gene can invoke changes in several cellular systems including the signaling pathways and receptors of growth factors and cell cycle tranducers, the apoptotic machinery which responsible for programmed cell death that normally disposes of abnormal cells, the secretion of telomerase, and local blood vessels which results in tumour-directed angiogenesis to supply nutrients to these tumours both aids the proliferation of cancer cells.7,8

Breast cancer cells are able to invade other tissues like the lymph nodes as they no longer exercise the same restraints as the normal cells and they also secrete enzymes like metalloproteainase to break down the extracellular matrix, conferring them mobility. Metastases are secondary tumours normally found in the advanced stage of breast cancer formed by cells released from the primary tumour and have reached and have established themselves at other sites like the lung brain or the bones which are common sites for metastatic cancers of breast origin through blood vessels and lymphatics. The tissues of lung, brain and bone origin express high levels of CXR4 chemokine receptors produced by the breast cancer cells, facilitating the selective accumulation of the cells at these sites.6

Treatment Options

There are three main approaches to treating breast cancer, namely surgical excision, irradiation and a host of systemic disease-modifying therapies or a combination and is chosen based on the stage of breast cancer. However, when caring for patients with advanced breast cancer, the goal of treatment of advanced breast cancer is to palliate symptoms, improve survival and quality of life. There are notably three types of systemic disease-modifying therapies to treat advance breast cancer namely endocrine therapy, chemotherapy and biological therapy.

Endocrine Therapy

Oestrogen exposure has been instrumental in inducing mutations that can lead to breast cancer as they can stimulate cell growth in most of human breast cancer cell lines expressing Oestrogen Receptor (ER) α .8 Clinical studies have proven that more than half of breast carcinomas are ER α positive and respond fairly well to endocrine therapy. Drugs are aimed either to change the ER signaling pathways or prevent estrogen synthesis.7 Tamoxifen and 3rd generation Aromatase Inhibitors (AI) have been used for advance breast cancer with the former being effective in premenopausal, perimenopausal and post menopausal women. Pre-menopausal and perimenopausal cancer patients with ER positive tumours should be offered Tamoxifen tablets 20 mg daily, an oestrogen -receptor antagonist and ovarian ablation or the administration of LHRH agonists such as Buserelin or Goserelin as first-line treatment.5,12 Both options are just as effective in terms of tumour response and overall survival rates.

The latter group of drugs, AI, are the preferred choice for post-menopausal women only with no prior history of endocrine therapy or have been previously been treated with Tamoxifen. AI work predominantly by suppressing oestrogen levels in post-menopausal women by blocking the conversion of androgens to oestrogens in the peripheral tissues. However, they do not inhibit ovarian oestrogen synthesis, hence can cause an elevation in oestradiol levels in pre-menopausal women. Anastrozole and Letrozole are non-steroidal AIs are known to be as efficacious as Tamoxifen as first -line treatment of metastatic breast cancer. 14Exemestane is a steroidal AI used as second-line treatment in advanced breast cancer in post-menopausal women in whom anti-oestrogen therapy has failed. Fulvestrant, an oestrogen receptor antagonist also confers short term benefits in the clinical setting for post-menopausal women who was previously prescribed a non-steroidal AI, delaying the need for chemotherapy. 13AI have been associated with an increased progression-free survival and 13% decrease risk of mortality and lower incidence of vaginal bleeds and blood clots. However, patients given AI are more prone to hot flushes and gastro-intestinal symptoms. 5 Other endocrine therapies available include older and less popular therapies such as progestogen and androgen for pre-menopausal women and stilboesterol and trilostane for post-menopausal women. 5

Chemotherapy

Both ER positive and negative patients with advanced breast cancer would benefit from either a choice of two or three regiments of chemotherapy and classes of drugs commonly prescribed includes antharacyclines, taxanes, capecitabine, vinorelbine, gemcitabine, alkylating agents like cyclophosphamide and platinum based drugs like carboplatin.5 Anthracyclines such as Epirubicin, Mitoxantrone and Doxorubicin are prescribed as first line chemotherapy as they boost modest survival advantage in patients with advanced breast cancer and are superior to non-anthracycline regimens.1,5Doxorubicin is commonly given via injection into a fast running infusion at 21 day intervals as extravastation can cause severe tissue damage. It exerts a cytotoxic effect by interfering with DNA and RNA synthesis by inhibiting DNA toposiomerase II action. The metabolites are excreted through the bile, hence elevated bilirubin levels are indicative of a need to reduce the dosage. 6,12 Higher accumulation of doses may result in cardiopathy precipitating to heart failure, hence cardiac monitoring is deemed important in managing cancer patients taking it and a limit of total cumulative doses is set at 450 mg/m2.Other symptoms of toxicity includes myelodysplasia and neutropenic sepsis. Doxorubicin is also available in liposomal formulations which are safer in terms of reduced incidents of cardiotoxicity and local necrosis but is not recommended by the Scottish Medicines Consortium for treatment of metastatic breast cancer.1,12

Both Epirubicin,an anthracycline derivative, and Mitoxantrone ,an anthracenedione derivative,are structurally related to Doxorubicin, hence similar drug activity could be predicted for all three drugs.12 Mitoxantrone given intravenously is licenced to treat metastatic breast cancer and has been well tolerated by patients.However, side effects like myelosuppression and cardiotoxicity are evident and cardiac examinations are recommended after a cumulative dose of 160 mg/m2.12When both drugs are compared in a clinical trial, Epirubicin boosts higher response rates despite demonstrating a higher percentage of toxicity related side effects.20Clinical trials suggest the efficacy of Epirubicin in treating advanced breast cancer is comparable to Doxorubicin as similar response rates were recorded when equal doses were given. These trials also indicated that patients taking Epirubicin had fewer episodes of congestive heart failure and other complications resulting from cardiotoxicity. Therefore, it could be surmised that Epirubicin is the drug of choice in this regimen .However,a limit of 0.9-1 g/m2 was still imposed when Epirubicin is given to avoid cardiotoxicity. 1,12

Due to the ineffectiveness of single-agent anthracycline therapies in impeding disease progression, combination therapies are often considered for the treatment of advanced breast cancer after failure of with anthracycline monotherapy, provided that the patient is able to tolerate additional toxicity and have a higher chance of response.5 There are clinical evidence suggesting that a combination of anthracycline and taxanes like Doxorubicin and Docetaxel have resulted in better tumour response, delayed progression time compared and reduce risk of mortality to anthracycline monotherapy. The benefits of this synergistic combination, however, did not include improved survival and side effects experienced were more numerous such as thrombocytopenia, alopecia in 75% of these patients,a 10% increase in peripheral neuropathy and neutropenia in 40 to 68% of these patients.1,5 A combination of Epirubicin and Docetaxel would be a better choice as it is just as potent as the Doxycycline and Paclitaxel combination but deemed free of side effects like cardiotoxicity and fluid retention whereas neutropenia was the dose-limiting toxicity .21

Systemic chemotherapy should be offered to patients whom antrhracyclines are contraindicated in cases of cardiac disease hypertension,the elderly, those who have received myocardial irradiation ,those receiving radiotherapy for breast cancer or had receive prior adjuvant treatment with anthracycline. Docetaxel monotherapy is prescribed as the first-line drug followed by single-agent Vinorelbine or Capecitabine as the second-line treatment. Third-line treatment encompasses the use of either Vinorelbine or Capecitabine of which was not offered previously.5 Docetaxel, a member of the taxane group derived from a naturally occurring compound from the bark of yew trees, is licensed to treat locally advanced or metastatic breast cancer. It acts by stabilizing microtubules in the polymerized state, preventing cell division. Side effects associated with Docetaxel are myelosupression, peripheral neuropathy, cardiac conduction defects with arrhythmias, alopecia, muscle pain, nausea and vomiting. Patients currently on Docetaxel are also susceptible to leg oedema and hypersensitivity reactions, which can be ameliorated by taking Dexamethasone orally.1,6,12 Antimetabolites like Capecitabine is a rationally designed tumour-activated and tumour-selective fluoropyrimidine carbamate thatis metabolized to generate 5-fluorouracil at the tumour site which would then be converted to fluorodeoxyuridine monophosphate (FDUMP), a ‘fraudulent’ nucleotide and interact and inhibit thymidilate synthetase,preventing the synthesis of 2′-deoxythymidilate (DTMP),which is vital for DNA synthesis.17Capecitabine has a role in second-line or third-line treatment of chemotherapy for patients of locally advanced or metastatic breast cancer either in combination with Docetaxel or given orally alone at a dose of 1250 mg/m2 twice daily for a forthnight and subsequent courses are repeated after a 7-day interval.

Vinorelbine is a semi-synthetic analogue of vinblastine, a vinca alkaloid derived from Madagascar periwinkle. Unlike taxanes, it is targeted at tubulin of mitotic microtubules to form tubulin dimers which prevents spindle formation in dividing cells leading to mitotic arrest at metaphase resulting in cell death. 6 Besides inhibiting mitosis, its effects are also significant in inhibiting leucocyte phagocytosis, chemotaxis and axonal transport in neurons. Hence, side effects includes neutropenia which was found to be the dose-limiting, peripheral or autonomic neuropathy which manifests as peripheral paraestesia, loss of deep tendon reflexes and motor weakness,constipation and abdominal pain. Neurotoxicity caused by Vinorelbine is considered relatively mild compared to other vinca alkaloids even at maximum tolerated dose as it preferentially binds to mitotic over axonal microtubules. 6,12 Vinorelbine is an option to anthracycline or taxane pre-treated patients with advanced breast cancer as second-line or third-line chemotherapy given via intravenous administration at a dose of 30mg/m2 in 250 ml of normal saline over 1 hour. Alternatively, Vinorelbine can be given orally at a dose of 60 mg/m2 for 3 weeks and can be increased if the patient shows good tolerance to the regime to maximum dose of 160 mg once weekly. A clinical response rates of 16-60% was seen with Vinorelbine as a single agent, 28-77% in combination chemotherapy.5, 16

A study comparing Vinorelbine in intravenous(i.v.) form used in combination with Capecitabine given orally and a combination therapy of Vinorelbine and Capecitabine both in oral formulations was done to observe the efficacy of both combinations in anthracycline and taxane pretreated patients with metastatic breast cancer. Despite showing a marginally higher percentage in control of the disease in the oral group,improved survival rates and lower incidence of neutropenia and thrombocytopenia were associated with the i.v. group.17 This study has also shown that a combination of Vinorelbine with Capecitabine therapy may confer advantages as both have unique mechanisms of action, different proposed mechanism of drug resistance and relatively non-overlapping toxicity profiles. However, this combination has yet to be recommended by the NICE or SIGN guidelines as it has yet to be proven to be cost-effective.

The recommendation for systemic chemotherapy by NICE is done following a cost-utility analysis which compares chemotherapy regiments in terms of survival, quality of life and associated costs of 17 different strategies drawn up. From the table below, strategies that gives the best survival rates and quality of life are combinations 3,4,13 and 15.However,combinations 3 and 4 that offer Gemcitabine and Docetaxel as the first line are somewhat more costly by approximately £ 10 000 in total costs compared to combinations 13 and 15.It is also proven here that offering Docetaxel as a first-line drug is also superior to Paclitaxel as survival rates and quality of life are slightly poorer in combinations 8 and 10. 5

Biological Therapy

New agents to specifically target molecular processes have been developed over the last decade like Tratuzumab, Bevacizumab and Lapatinib which are all used to treat advanced breast cancer. Tratuzumab, the sole drug of its kind recommended by NICE for use in the UK, is a recombinant humanized monoclonal antibody which binds to Human Epidermal Growth Factor (HER2) on the cancer cells with HER2 over expression and impedes the growth. Hence, HER2 status should be assessed before commencing this therapy as only a quarter of patients with advanced breast cancer have HER2 positive tumours. Tratuzumab is given intravenously in combination with Paclitaxel, Docetaxel or Vinorelbin has been well tolerated. 5,11However, once disease progression occur outside the central nervous system, Tratuzumab should be discontinued. Bevacizumab is another monoclonal antibody aimed at affecting the growth of tumour blood vessels and Lapatinib affects the metabolic pathways of the HER2 and Epidemal Growth Factor Receptor (EGFR). 5,23.

Surgery

Surgical intervention comprises of conservation surgery which involves the removal of the tumour with a rim of surrounding breast tissue with retention of the breast followed by radiation therapy and mastectomy which is usually followed by breast reconstruction. However, these surgical procedures are limited to patients diagnosed with primary operable breast cancer or as palliative surgery for locally advanced breast cancer as they may not confer much benefits to patients diagnosed with later stages of breast cancer.1,11,19 Some patients may have already underwent surgery which was not very successful in eliminating the disease.1

Treatment Recommendation

Hormonal therapies are the recommended first-line therapy for patients with an ER positive tumour, are widely used and are said to be appropriate for 70 % of patients who have hormone receptor -positive advance breast cancer. However, in circumstances whereby the disease is life-threatening or the patient has an ER negative tumour, the hormonal therapy would be of no benefit to these patients. At the time of initial diagnosis, the oestrogen receptor (ER) was accessed and the results came out positive before considering commencing on endocrine therapy. Several factors like previous endocrine therapy including adjuvant therapy, the extent and period of response to the therapy and menopausal status have to be taken into account before prescribing hormonal therapy. 5The patient is 62 years of age and is considered to be post-menopausal, hence would benefit tremendously when given aromatase inhibitors(AI),regardless of whether she is tamoxifen naïve. A choice of non-steroidal AIs of either Anastrozole 1 mg daily or Letrozole 2.5 daily could be given orally. However, if she has a prior history of non-steroidal AIs and she failed to respond well to it, she should be given either Exemestane 25 mg orally or Fulvestrant 250 mg via intramuscular injection into the gluteal muscle every 4 weeks.5,12

Chemotherapy would be the second choice of treatment following failure to respond to hormonal therapy. If anthracyclines are not contraindicated for this patient, Epirubicin would be a good choice. Initial doses of 75 mg/m 2 of Epirubicin could be given intravenously every three weeks.20The addition of Docetaxel 75 mg/m2in combination with Epirubicin 90 mg/m2 both by intravenous infusions could be given should Epirubicin monotherapy fails. Docetaxel monotherapy could also be given as an intravenous infusion at a dose of100 mg/m2 as a 1-hour intravenous infusion every 3 weeks should anthracyclines be contraindicatedas first-line chemotherapy. Vinorelbine monotherapy could be given intravenously at a dose of 30 mg/m2 for days 1 and 8 of a cycle or whereares Capecitabine monotherapy could be given orally at a dose 1250 mg/m2 twice daily for two weeks. If the patient fails to respond to the entire treatment, the last resort would be to offer support and palliative care to this patient.

Pain Management

Pain is usually associated with progression of cancer with three quarters of patients with advanced cancer reporting pain during treatment. The principles for treating pain in cancer patients are outlined by the World Health Organisation (WHO) analgesic ladder:

Patients are the prime assessor of pain and should have treatment outcomes monitored regularly using visual analogue scales, numerical rating scales. Patients usually start with non-opioids and then progress stepwise to step 2 and step 3. However, critics have debated that the progression to step 2 analgesics was obsolete as inadequate pain control was an issue despite having to endure similar adverse effects when given step 3 analgesics and recommended a immediate step up to step 3. Most patients with advanced breast cancer will be on step 3 for pain control. Oral morphine with an initial dose of 5-20 mg every four hourly, adjusted according to patient’s response, would be the first-line therapy to treat severe pain in cancer before switching to a modified release preparation once the patient is stabilized on it. Breakthrough pain should be managed while on a modified release preparation by prescribing oral morphine at 1/6th of the total daily dose to be taken when necessary. The use of adjuvants such as antidepressants like Venlafaxine and anticonvulsants like Gaba-pentin are recommended for neuropathic pain. 18

Managing Complications

Complications that may arise from treating patients with advance breast cancer includes lymphoedema,cancer-related fatigue,uncontrolled local disease,bone metastases and brain metastases. Lymphoedema may occur due to damage to lymph nodes and vessels following surgery and radiotherapy or as a sign of loco-regional disease progression. This condition can be managed through manual lymphatic drainage, multi-layer lymphoedema bandaging,goos skin care and remedial exercise. Cancer-related fatigue may be well managed by identifying the factors causing lethargy which may be a host of psychological, nutritional and cognitive factors apart from the cancer itself and them treating them accordingly. Patients may also develop local disease characterized by ulceration on the chest wall and axilla, fungating tumours that may bleed and exude discharge, causing pain and giving off repulsive odours. Hence, good wound management should be adopted in relation to preventing dire consequences when wounds are left unattended.

Out of the three categories, cancer with distant metastases is the hardest to treat and is considered an incurable disease with palliative care being the sole priority in treatment plans. A diagnosis of metastatic disease could be confirmed with the use of positron emission tomography fused with computed tomography (PET-CT) and bone scintilography.1As bone metastases may be a long-term condition, management involves prevention of skeletal events, pain control with Biphosphonates,radiotherapy and cementoplasty and treating complications such as fractures,immobility and spinal cord compression.5,18 Brain metastases may develop in multiple sites in these patients as most drugs used in chemotherapy cannot penetrate the blood brain barrier, especially in women with HER2-overexpressing tumours. Diagnosis of brain tumours ultimately mean a loss of independence, physical deterioration, communication difficulties,psychological distress and issues regarding body image.Treatment regimens includes surgery for patients who have solitary metastasis, corticosteroids for symptomatic relief of inflammation and radiotherapy.

What trends have created a push for nursing practice based on evidence? Remember to use references.

What trends have created a push for nursing practice based on evidence? Remember to use references.

 

 

Give a brief definition of nursing research and evidenced-based research. Explain differences and similarities. Remember to use references.

Why should nurses incorporate research? What trends have created a push for nursing practice based on evidence? Remember to use references.

Pls use this book as one of the references.
Houser, J. (2015). Nursing research: Reading, using, and creating evidence (3rd ed.). Sudbury, MA: Jones and Bartlett.”

 

A 31-year-old African American female is concerned about a white vaginal discharge. She has self-treated in the past with over-the-counter vaginal c??reams with some success. She has had no relief thus far for this episode.

A 31-year-old African American female is concerned about a white vaginal discharge. She has self-treated in the past with over-the-counter vaginal c??reams with some success. She has had no relief thus far for this episode.

3.Consider a differential diagnosis for the patient in this case.( at least two) 4. Think about the most likely diagnosis for the patient with white vaginal discharge.
5.Think about a treatment and management plan for the patient. 6.Be sure to consider appropriate dosages for any recommended pharmacologic and/or nonpharmacologic treatments.
7.Consider strategies for educating patients on the treatment and management of the sexually transmitted infection you identified as your primary diagnosis
8.CONCLUSION
Coarse TEXT
Required Readings
Schuiling K. D. & Likis F. E. (2013). Womens gynecologic health (2nd ed.). Burlington MA: Jones and Bartlett Publishers.
Chapter 11 Sexuality (pp. 209225)
This chapter explores components of female sexuality including sexual desire sexual response and womens views of themselves in society. It also examines strategies for maintaining satisfactory sexual health in women.
Chapter 20 Gynecologic Infections (pp. 467483)
This chapter identifies strategies for assessing diagnosing and managing patients experiencing gynecologic infections. It also provides recommendations for treating gynecologic infections including alternative treatments for pregnant women.
APPROVED RESOURSES
1 Up to Date (must use original articles from Up to Date as a resource)
2. Wikipedia
3. Cdc.gov- non healthcare professionals section
4. Webmd.com
5. Mayoclinic.com
6. Babyzone.com
7. Americanheartassociation.com

Meredith S. Murphy September 18, 2017

Heart Failure Clinical Scenario: Paper Analysis

Clinical Scenario Paper

The

case scenario

in question relates to an 80 year old patient who presents with SOB for 2 days, bibasilar rales and expiratory wheezes. He has 2+ lower extremity non-pitting edema which is unchanged from the previous visit. The rest of the PE is otherwise unremarkable. The patient has a history of CAD, HTN, CKD 3, CHF and COPD. The patient is currently taking lisinopril 10mg QD, metoprolol 12.5mg BID, ASA 81mg daily, Combivent one puff QID, Lasix 20mg QD and KCL 10meq QD.


Heart failure (HF)

is defined by the American College of Cardiology (ACC) and the American Heart Association (AHA) as a complex clinical syndrome resulting from structural or functional impairment of ventricular filling or ejection of blood (Collins-Bride, 2016). The diagnosis of HF is primarily clinical based on classical symptoms including dyspnea, fatigue, fluid retention and exercise intolerance. HF can involve the left ventricle, the right ventricle or both. Left ventricular failure predominantly involve dyspnea and fatigue arising from pulmonary edema whereas right ventricular failure include peripheral edema, ascites, hepatic and splenic congestion secondary to systemic fluid congestion. The most important causes of HF are coronary artery disease (CAD) and hypertension (HTN) (Kennedy-Malone, Fletcher, & Martin-Plank, 2014). Based on the patient’s presenting symptoms and history it appears that he is experiencing an exacerbation of his heart failure. Two evidence based practice articles will be utilized to help inform the diagnosis. One paper focuses on a quantitative approach while the other utilizes a qualitative approach to inform the diagnosis of HF. The conclusion will include the recommendation for the given scenario of the best paper and the rationale for choosing one paper over the other.

Quantitative Research Article

The quantitative paper that was chosen is
the “2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of
the American College of Cardiology Foundation/American Heart Association Task
Force on Practice Guidelines”.   There are certain criteria that are used to
critique the quality of quantitative trials such as the purpose of the
research, the depth and quality of the literature review, the overall
objectives of the research, adequate sample size calculations, the methodology
is clearly highlighted (validity and reliability), the analysis of the
quantitative research needs to clearly demonstrate which statistical methods
were utilized for the conclusions and the discussion/conclusion section needs
to be supported by the research data presented (Greenhalgh, 2014). The paper
was a good choice as it summarized the existing literature on the diagnosis and
management of HF based on the level of evidence (quality of the trials used in
the analysis) and the class of recommendation reflecting the size of the
treatment effect. The American College of Cardiology Foundation (ACCF) and the
American Heart Association (AHA) Task Force developed these clinical practice
guidelines to ensure balanced, evidence-based and patient-centric
recommendations for clinical practice. According to Greenhalgh (2014) there are
additional critical review criteria applied to guidelines that needed to be
considered when choosing this paper. 1) Did the preparation of the guideline
involve a significant conflict of interest? This guideline required all
“committee members and peer reviewers of the guideline to disclose all current healthcare-related
relationships, including those existing 12 months before initiation of the
writing effort” (Yancy et al., 2013). “The writing committee chair plus a
minimum of 50% of the writing committee have no relevant relationship with
industry” (Yancy et al., 2013). Therefore, this paper was a good choice. 2) Is
the guideline concerned with a specific topic and appropriate target group? The
paper specifically addresses the comprehensive needs of the HF patient.  3) Did the guideline committee include
experts in the topic area? The guideline included experts (cardiologists,
internists, electrophysiologists, transplant specialists, & RNs) and
independent reviewers with methodological expertise. 4) Were any subjective
judgments by the panel made explicit? Yes, the recommendations were evidenced
based “wherever possible” (Yancy et al., 2013). 5) Were all the data rigorously
scrutinized and evaluated? Yes, an extensive literature review was conducted
with over 40 independent reviewers (Yancy et al., 2013).  6) Was the evidence properly synthesized and
were the conclusions based on the data presented? Yes, the guideline
synthesized the data and conclusions into recommendation based on the level of
evidence and the class of recommendation. 7) Do the guidelines address
variations in medical practice and other controversial areas? Yes, the guidelines
are intended to “assist clinicians in clinical decision making by describing a
range of generally acceptable approaches to the diagnosis, management, and
prevention of specific diseases or conditions. The guidelines attempt to define
practices that meet the needs of most patients in most circumstances. The
ultimate judgment regarding care of a particular patient must be made by the
clinician and patient in light of all the circumstances presented by that
patient. As a result, situations may arise for which deviations from these
guidelines may be appropriate” (Yancy et al., 2013).   8) Are the guidelines written from the
perspective of the practicing doctor, nurse, etc.? Yes, the guidelines
specifically state that they attempt to define practices to meet the needs of
most patients but deviations from the guidelines may be appropriate in certain
clinical situations. This speaks directly to the applicability of the guidelines
to the end practitioner versus the academic or policy maker.  This addresses a major critique of guidelines
cited by Greenhalgh in chapter 1 of her book, “why do people sometimes groan
when you mention evidence-based medicine” (Greenhalgh, 2014). 9) Does the
guideline take into account what is acceptable to, affordable by, and
practically possible for patients? Yes, it specifically controlled the level of
industry involvement to reduce the likelihood of bias. 10) Does the guideline include
recommendations for its own dissemination?  Yes, “in an effort to maintain relevance at
the point of care for practicing clinicians, the Task Force continues to
oversee an ongoing process improvement initiative where several changes to
these guidelines will become apparent based on the results of ongoing pilot
projects”(Yancy et al., 2013). Based on the patient’s change in clinical status
it is recommended that the patient presenting with acute decompensated HF,
should undergo a chest x-ray to assess heart size and pulmonary congestion and
to detect alternative cardiac, pulmonary, and other diseases that may cause or
contribute to the patient’s shortness of breath. Recommended lab studies
include complete blood count, complete metabolic panel, magnesium  level, cardiac enzymes, urinalysis, thyroid-
stimulating hormone, 12- lead electrocardiogram (Level of Evidence: C) and
brain natriuretic peptide (BNP) (Level of Evidence: A). Determining BNP level
is useful for establishing prognosis or disease severity in patients chronic
HF. Also, “a repeat measurement of EF and measurement of the severity of
structural remodeling are useful to provide information in patients with HF who
have had a significant change in clinical status” (Yancy et al., 2013). The
2-dimensional echocardiogram with Doppler flow studies is the most useful
diagnostic test to assess changes to ventricular function.  Level C recommendations indicates that the
procedure or treatment is useful based on standard of care and expert
recommendations.  Diuretics are
recommended for HF patients with evidence of fluid retention unless
contraindicated to improve symptoms. Given the patient’s symptoms the Lasix
should be increased to 20 mg twice daily (standard recommendation is 20-40 once
or twice daily).  Because the patient is
presenting with symptomatic HF he should also be placed on sodium restriction
of <3g daily to reduce congestive symptoms (Level of Evidence: C) (Yancy et
al., 2013).

Qualitative
Research Paper

The qualitative paper that was selected is titled
“Improving care for heart failure patients in primary care, GP’s perceptions: a
qualitative evidence synthesis” by Smeets and colleagues published in the BMJ
in 2016. This qualitative article was interesting because like the previous
quantitative article, reflects a synthesis and meta-analysis of the qualitative
evidence related to the management of HF patients. This paper was unique
because it was one of the first papers to synthesize the qualitative data
related to the management of HF patients from 18 qualitative papers. The paper
concluded that HF was very difficult to diagnose due to lack of specificity of
symptoms, was associated with significant communication issues between the
patient and the multidisciplinary care team, and that the implementation of HF
guidelines was underutilized by primary care physicians
(Smeets et al., 2016). The paper discussed the importance of the
clinical diagnosis, use of chest x-rays, ECGs, laboratory work, and
echocardiograms to manage patients. The current treatment recommendations were
also discussed as was the difficulty of pharmacologically managing the complex
patient with multiple comorbidities such as is the case with our case scenario.
The paper concluded that there was a clear need to improve the diagnosis of HF
with the use of echocardiography and natriuretic peptides that may limit the
number of cases requiring echocardiography. There is a need to translate
existing HF guidelines into more usable local guidelines through the
intervention of local experts. Finally, the paper confirmed the need for
multidisciplinary collaboration. General practitioners admitted that they
feared losing patients to specialists if they referred them (Smeets et al.,
2016).

Similar to the first paper, Greenhalgh
(2014) cites several criteria by which to evaluate or critique the quality of
the qualitative research in question. 1) Did the paper describe an important
clinical problem? Yes, the paper synthesized 18 qualitative barriers assessing
the diagnosis, management and barriers to management of HF patients. 2) Was a
qualitative approach appropriate? Yes, the goal was to synthesize qualitative
papers to gain a deeper understanding of the barriers to care of HF patients.
3) How were the setting and the subjects selected? The authors conducted a
comprehensive literature search and selected only papers that used qualitative
data collection methods. Descriptive and opinion papers were excluded. 4) Was
the researcher’s perspective taken into consideration? Yes, the authors
approached the work specifically from a qualitative research perspective and
sought to synthesize previously conducted original studies. 5) Was the
methodology used described in detail? Yes, the authors describe their
methodology in detail including their critical appraisal methods using the
Critical Appraisal Skills Program (CASP). 6) Did the authors employ a thematic
analysis to their work? Yes, the authors utilized a thematic analysis that
“preserved an explicit and transparent link between conclusions and the text of
the primary studies” (Smeets et al., 2016). 7) Are the results credible and
clinically important? Yes, the authors cited the 18 primary papers used for
their analysis. The results are of high clinical value because it confirmed the
need for better communication of HF guidelines to the community clinician. 8) What
conclusions were drawn and are they justified by the results? Yes, the
conclusions were directly supported by the original research. The
recommendations made are of high clinical importance in my opinion. 9) Are the
findings of the study translatable to other settings? Here, it can be said that
were partially transferrable. The synthesis of qualitative data in the HF
population was a relatively new endeavor and the authors identified a new
method to ensure transparency. The results are primarily based on the UK
population which makes generalizability more challenging to the US population.
However, it can be said that the basic approach to the clinical diagnosis and
management of CHF is similar between Europe and the US with minor regional
variations.

Both a systematic review of quantitative data and a systematic analysis of qualitative data in the diagnosis and management of heart failure were reviewed. Both reviews provide valuable evidence by which to approach the given case scenario. One is very proscriptive in the steps involved in the diagnosis and management and the other highlights the challenges of diagnosis and management encountered by physicians and associated multidisciplinary teams. The qualitative review highlights how challenging the diagnosis of HF is given the presence of non-specific symptoms and the lack of awareness of treatment guidelines among the primary care practitioners. Both reviews were found to be of high quality and high clinical relevance. With respect to the given case scenario the quantitative guidelines publication applies best because it provides the evidentiary base on the differential diagnosis and the step wise management of the patient.

References

  • Collins-Bride, G. (2016).

    Clinical Guidelines for Advanced Practice Nursing

    (3rd ed.). Burlington,, MA: World Headquarters, Jones & Bartlett Learning.
  • Greenhalgh, T. (2014).

    How to read a paper: the basics of evidence-based medicine

    (5th ed.). Oxford, UK: Wiley Blackwell.
  • Kennedy-Malone, L., Fletcher, K. R., & Martin-Plank, L. (2014).

    Advanced practice nursing in the care of older adults

    . Philadelphia, PA: F.A.Davis Company.
  • Smeets, M. (2016). Improving care for heart failure patients in primary care, GPs’ perception: a qualitative evidence synthesis.

    Bmj Open, 6

    .
  • Yancy, C. W. (2013). 2013 ACCF/​AHA Guideline for the management of heart failure: A report of the American College of Cardiology Foundation/​American Heart Association Task Force on practice guidelines.

    Circulation, 128

    .

Ph.d interview questions | ph.d

WRITTEN INTERVIEW QUESTIONS

Doctoral candidates should provide an authentic personal statement to each of the five following questions/prompts reflecting on their own personal interest. In the event that any outside resources are used, resources should be cited in APA format. Submissions should be a maximum of 500 words or 125 words per question/prompt. It is best to response to each prompt/question individually for clarity of the reviewer. Writing sample should be submitted in Microsoft Word format and include candidate’s name.

Academic Carrier

1) Bachelor’s in computer Science Technology ( Jawaharlal Nehru Technological University Hyderabad)

Subjects: PROBABILITY AND STATISTICS,

MATHEMATICAL FOUNDATION OF COMPUTER SCIENCE, DATA STRUCTURES THROUGH C++,

DIGITAL LOGIC DESIGN,

ELECTRONIC DEVICES & CIRCUITS

COMPUTER ORGANIZATION,

DATA BASE MANAGEMENT SYSTEMS,

OBJECT ORIENTED PROGRAMMING,

ENVIRONMENTAL STUDIES,

FORMAL LANGUAGES & AUTOMATA THEORY, DESIGN & ANALYSIS OF ALGORITHMS

LINUX PROGRAMMING , SOFTWARE TESTING METHODOLOGIES,

DATA WAREHOUSING AND DATA MINING

COMPUTER GRAPHICS

MOBILE COMPUTING

DESIGN PATIERNS

2) Master’s in Computer Science ( Northwestern Polytechnic University,Fremont,CA, USA)

Subjects: Data Modeling and Implementation Techniques, Java and Internet Applications, Advanced Structured Programming and Algorithms, UNIX/Linux Network Programming

Network Analysis & Testing, Network Security i’undamentals and Computer Science Capstone Course

3) Master’s in Information Technology Management (Campbellsville University, Louisville,KY,USA)

Subjects: Project Management,Information System Infrastructure,Management Information Systems,Information System Security,Team Management,Negotiation and Conflict Mgt.

Current & Emerging Technology,Disaster Recovery Planning,Cyberlaw, Regulations, & Compliance, ITM Capstone

Current Job: Lead Software Engineer (Qlik)

PhD IT

Tell us about yourself and your personal journey that has lead you to University of the Cumberlands.

What are your research interests in the area of information technology? How did you become interested in this area of research?

What is your current job/career and how will this program impact your career growth?

What unique qualities do you think you have that will help you in being successful in this program?

How can obtaining a doctorate impact your contribution to the practices of information technology? Where do you see yourself after obtaining a doctorate from UC?

ADM 626 ASSIGNMENTS BUNDLE WEEK 1 TO 4

Description

ADM 626 Assignments Bundle Week 1 to 4

Below shown is the content for “ADM 626 Assignments Bundle Week 1 to 4“.


Week 1 Assignment Module Assignments

Complete all questions in the assignment section of the Module. Assignments can be completed in Word documents and/or Excel spreadsheets.

Module 2: pages 8-10 *for the Module 2 assignment you will need to use the self-checking Excel spreadsheet attached.

Module 11: page 105


Week 2 Assignment Module Assignments

Complete all questions in the assignment section of the Module. Complete the assignments in Word documents and/or Excel spreadsheets.

Module 3: pages 26

Module 10: page 82


Week 3 Assignment Module Assignments

Complete all questions in the assignment section of the Module. Assignments can be completed in Word documents and/or Excel spreadsheets.

Module 6: page 45

Module 9: page 70-73

The Module 13: page 129-134


Week 4 Assignment Module Assignment

Complete all questions in the assignment section of the Module. Assignments can be completed in Word documents and/or Excel spreadsheets.

Module 4: page 29-30

Module 12: page 120-121

The Module 25: page 250-251


 

Instructions Stock RepurchasesIn the short article Royal Dutch Shell Finally Delivers Big Stock Buyback- But Shares Break Support by Aparna Narayanan (see below)- stock repurchases may produce favor

Instructions

Stock RepurchasesIn the short article “Royal Dutch Shell Finally Delivers Big Stock Buyback, But Shares Break Support” by Aparna Narayanan (see below), stock repurchases may produce favorable effects on key financial ratios.Narayanan, A. (2018, July 26). Royal Dutch Shell finally delivers big stock buyback, but shares break support. Investors Business Daily. Retrieved from https://libraryresources.columbiasouthern.edu/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=bth&AN=131003207&site=ehost-live&scope=siteAfter reading the article, write an essay that addresses the prompts below.

  • Include an introduction that summarizes the article.
  • Analyze the importance of stable dividend policies.
  • Determine reasons behind stock repurchases.
  • Analyze how individual financial metrics are specifically affected by stock repurchase plans and returns.

Your essay should be at least two pages in length, not counting the title and reference pages. You are required to cite and reference at least your textbook and the article. Use APA format to cite in-text and reference citations.

How does Mentorship, Opportunity and positive organisational culture impact on the ability to identify and cultivate nurse leaders.

How does Mentorship, Opportunity and positive organisational culture impact on the ability to identify and cultivate nurse leaders.

 

I need support in writing the second part of an assignment. Part 1 asked me to write a 750 word outline of a journal article. Part 2 asks to extend this to a 2750 word article.

Minimum of 15 references no older than 5yrs unless historical significance is explained.
Referencing using APA 5th Ed format.
References must come from Leadership and Management literature. NO Textbooks, pop-culture books or general websites.
Must include: Introduction, Discussion with own section/sub-section headings, conclusion and reference list.

Focus on leadership theory and why it is essential we identify young leaders within the nursing profession. How does it benefit the individual, the organisation, the patient?

How does Mentorship, Opportunity and positive organisational culture impact on the ability to identify and cultivate nurse leaders.

Please use the outline essay attached as the basis to the essay. Follow the headings identified and elaborate further with academic research.
Currently 1 writers are viewing this order

Heart Disease: Symptoms- Treatments and Impacts on the Population


Abstract

The purpose of this paper is to thoroughly analyze Heart disease in the world today and how it has and currently affecting adults. Heart disease in America kills around 610,000 people each year nationwide as it is the leading cause of death in adults. But what is Heart disease? Coronary heart disease, which is often also called heart disease is the main form of heart disease. It is a disorder of the blood vessels within the heart that can lead to heart attack. When a heart attack occurs, the artery becomes blocked which prevents nutrients and oxygen from getting to the heart. Heart disease is just one of several cardiovascular diseases all of which are diseases of the blood vessel and heart system. There are other cardiovascular diseases including, high blood pressure, stroke, rheumatic heart disease, chest pain. Heart disease is a lifelong condition so unfortunately once an individual is diagnosed with it, they will have it forever in their system.


Anatomy of the Heart

The heart in an individual is one of the body’s most important organs. Essentially the heart is a pump and a muscle that is made up of four chambers separated by valves and divided into two halves. Each one of the half contains one chamber called a ventricle and one called an atrium. The atria collects the blood, and the ventricles contract in and out to push blood out of the heart. The right half of the heart pumps oxygen-poor blood which is blood that has a low amount of oxygen. This then travels to the lungs where the blood cells can obtain more oxygen. Therefore, the newly oxygenated blood travels from the lungs and into the left atrium, lastly entering the left ventricle of the heart. The left ventricle pumps the now oxygen rich blood to the organs and tissues of the body. This oxygen provides the patient’s body with energy and is essential to keep the body healthy. The general term used to determine the malfunctions of the heart is Heart Disease, or sometimes Cardiac Disease. Though there are multiple forms of heart disease, the two common forms of heart disease are a Heart Attack and Heart Failure. As both of these diseases are to some extent avoidable, there are ways and methods that an individual can take to decrease their chances of having to deal with heart disease, or to at least minimize the negative effects of existing heart disease. There are recent procedures that have been evolved such as bypass surgery and percutaneous coronary intervention this can help blood and oxygen flow to the heart more easily. But even with these procedures, the arteries still remain damaged. This most acceptably means that those individuals are more likely to have a heart attack. What’s more, the condition of someone’s blood vessels will steadily worsen unless they make changes in their daily habits. Many men and women in America have died of complications from heart disease and heart related problems and still to that day, the number is still growing. That’s why it is so vital for this nation to take action to prevent and control this disease. According to the

US national Library of Medicine

, “Half of adults have at least one cardiovascular risk factor. Not even 1% of the population attains ideal cardiovascular health. Despite falling coronary death rates for decades, coronary heart disease (CHD) death rates in US women 35 to 54 years of age may now be increasing because of the obesity epidemic.” People around the nation unfortunately has just become to accustom to the standards around us that Adults are often putting a “want” before a “need” when it comes to their health.


Symptoms of heart disease

Learning about how heart disease affects an individual has a high importance as different symptoms can relate to different heart related issues but knowing what to do in any heart situation is beneficial and valuable. Here are some of the symptoms an individual may notice if they have a heart related issue. The most common symptom of coronary artery disease is

angina

, or also known as

chest pain

. Angina is a medical term which can be described as a having discomfort, heaviness, aching, pressure, burning, squeezing, fullness, or painful feeling in a person’s chest. It can be mistaken for

indigestion

and or

heartburn

. Angina may also be felt in the shoulders, neck, arms, back throat, or jaw. Other symptoms of coronary artery disease include Shortness of breath, a faster heartbeat, palpitations,

weakness

or

dizziness

, sweating, and nausea. Unfortunately there is not much of a difference from the symptoms of heart disease, and the feeling of a heart attack. However; when a heart attack is occurring it typically will last 30 minutes or longer and have no sense of releasement of pain even when using oral medications. Initial symptoms may start as a mild discomfort in the chest and throat but will eventually progresses to significant pain that can be described as unbearable. Some people have a

heart attack

without having any symptoms at all, which is known as a silent myocardial infarction. While this is not a very common to interaction with the heart, more often than not it happens to people with

diabetes

.


Heart Disease affecting the population

The United States population in particular, among the older age groups is continuing to expand daily at an alarming rate. Because of the incidence of heart failure increasing with age, largely due to the development of heart failure risk factors such as coronary artery disease and hypertension, the epidemic of heart failure is likely to grow further into the upcoming decades. While some assert that the life expectancy is approaching its natural limit and heart related mortality’s are slowing life expectancy gains, the steady increase in Heart disease has been observed over the past century and yet in recent years it has not waived this increase in the aging population having implications with heart failure. According to

Impact on Heart Failure

, “Over the next two decades, the proportional increase in the generality of heart failure will likely exceed cardiovascular diseases and is likely going to be driven by the aging of the population nationally”. Certain minority groups also face a greater risk than others. These differences have appeared to come from an increased amount of high blood pressure, obesity, and diabetes seen in some populations that are in contrast with that of Caucasian Americans. Still, Genetic differences do exist. But diversity within different ethnic and racial groups means that genetic traits common to some groups can’t be rationalized to an entire race. For example, according to the

Office of Minority Health

, “while six percent of Caucasian American and African American adults are living with heart disease, African American men are thirty percent more likely to die from heart disease, as compared to Caucasian American men”. Alaska Natives and American Indians, on average are more likely to be diagnosed with heart disease and heart failure than their Caucasian counterparts. For people of all ethnicities, knowing and properly managing their biometric numbers such as cholesterol levels, blood pressure, and weight can prevent or delay heart disease and its complications in an individual.


Recent Advancements in Heart Disease

With Heart disease as one of the leading deaths in America researchers are always looking for recent advancements and ways to continue to better prevents heart disease in adults. Recently, Physicians and Researchers have created remarkable advancements in treating heart disease. The future has not become even more positive for adults with 200 new heart disease and stroke medications in development. Among, these medicines is a treatment for patients with coronary heart disease and low levels of high density lipoprotein. This medicine is an inhibiter of the bromodomain an extra terminal protein. It is thought the protein can reproduce specific biological effects than will be able to provide health benefits to these patients and reduce the prevalence of adverse cardiac events. Another possible treatments is a non-viral gene therapy that targets tissue repair and regeneration in the body. So many adults rely on the multiple forms of medications in the market of the nation today, this is including Beta blockers such as, Bisoprolol as well as, angiotensin-converting enzyme inhibitors Captopril and Enalapril. The majority of these medications work by blocking the effects of hormones that are released by the body during heart failure. These medications happen to work relatively well in the early to mid-stages of heart failure, but unfortunately once the patient reaches the later stages of heart failure, the effectiveness of the drops significantly. They also come with serious side effects of which includes worsening kidney function and hypotension. There are however Pacemakers, which are also known as cardiac resynchronization therapy, these devices have been around for more than half a century. These small devices consist of electrodes that are implanted into the heart and deliver electrical impulses to regulate the heartbeat within the individual. Two other main classes of devices are implantable cardiac defibrillators and ventricular assistance devices. Both of which work similar to pacemakers, using electricity to correct irregular heartbeats and supply supplementary pumps of pressure that help the heart pump blood in and out of the ventricles. Within the past decade there have been major breakthroughs in sensor and nanotechnology have made cardiac resynchronization therapy and implantable cardiac defibrillators. Now most patients now have a single device that does both the job of a CRT and ICD safer and more reliable for the patient. Previously, these devices were imprecise, occasionally causing violent hiccups. Doctors are now able to position multiple sensors more precisely on different chambers of the heart this allows for more coordination. Physicians are able to take patients who had poor responses to cardiac resynchronization therapy and allow them to have positive responses, this is all due to miniaturization technology which is the trend to manufacture smaller electronic, optical and mechanical products and devices.


Social and economic factors



Heart disease is a compound condition that is a leading cause of death worldwide. It is often seen as a disease of overflow, yet is strongly associated with a socio-economic status. It’s highly complex causality means that many different factors of social and economic life are compromised in its cause of disease, these factors are determined through such as workplace hierarchy and agricultural policy combined with other factors to together result in a pass for an individual lifestyle. The untangling of causes for heart disease thus automatically raises moral, political, and, social issues. These include the accepted role of the individual and of larger social efforts in its prevention’s and treatment. The construction of risk factors for heart disease likewise is embedded with questions of organized justice in the responsible direction of those at risk for heart disease, a debate within the medical literature that has received much attention, but less intriguing within the ethical literature. For example, prevention strategies may raise composite issues of responsibility and of judgements of what it is to exactly live well. After all if there was a true way to live well, who is to say what that definition entails? More than twenty three million adults worldwide have heart failure, an astounding number to a millennial such as myself. Even though over time the survival of life after the diagnosis of heart disease or heart related issues has improved, ephemerality from heart failure still remains high today. Approximately fifty percent of people diagnosed with heart failure will die within five years. Many of these patients will progress to advanced heart failure, this is characterized by symptoms at leisure despite the maximum medical therapy. These patients are considered obstinate, both the patient and the physician upon reaching this form of state are faced with ethical issues that can be very difficult to determine what is best for the patient. There has been consideration over advanced therapies including, left ventricular assist devices or a transplant, involvement of palliative care, transitioning into hospice care, as well as end of life issues such as advance directives and implantable cardioverter-defibrillator deactivation that have the need to be conveyed. Now, may advance therapies such as LVADs and cardiac resynchronization therapy have become more readily available to patients who are older as well as more obstinate. Expanding the indications for device therapy in heart failure are based on expert opinion regarding their effects and clinical trials in a beneficial way. However, careful consideration must come into perspective and be given to the cost to the general public, the potential to reduce the quality of life, the possibility of doing harm to the individual, and disparities in the care of acute heart failure patients.


Conclusion



Heart disease in America is a topic that is very commonly discussed in doctors’ offices everywhere in the nation and I believe needs to continue to be adamantly researched to hopefully find a prevention for this disease. There are many preventions I believe people would take part in to prevent heart disease but unfortunately just do not have the resources available to them or the knowledge and means to be able to find a cure. Factors including Race, ethical issues, financial relations, and overall health are all contributing to the number one cause of Death nationally. But as a nation, particularly America; will Adults have the drive to come together to help fight this disease one heart at a time? We can only hope so and for a cure, which starts within the everyday individual taking strides to better their overall heart health.


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