Strategies to Strengthen Memory Skills

Memory is the power or process of remembering what has been learned. It can be bunches of information that you’ve learned from school, internet, and experiences, either good or bad. Memory is like a very big storage in our head. You yourself will be shocked from the things that are in store with it. When we remember or recall something, our memory is involved to it. Our memory is an essential in our daily lives, because once our memory failed to function, we will experience difficulties in remembering faces, numbers, and even directions. Won’t it be a burden for us and for others too?

As we get older, the capability of our memory fades away. As a human being, our memory will be needed for a lifetime in every simple ways we do. Our memory is very important in order for us to get into school, university, and get a career or profession that we want. The job of our memory does in remembering wholly depends on our actions. Daily intake of healthy foods will make our memory function properly. We don’t just eat to fill our stomach. We must consider the nutrients that we get from it to become physically healthy, and mind healthy. Food isn’t just enough. It requires teamwork with vitamins that will further make us healthy. Memory also needs energy to work. Aside from food, enough sleep after a long tiring day is a must. Just like our body, it also gets tired if overused. Physical and mental exercises also contribute to a good memory. Our memory also needs to be trained so it will be in good condition. We socialize every day, every hour, and every minute. Having an active interaction with the same or opposite gender will pro-long the stored memories in our mind.

Memory is very important yet, losing it is common these days. Humans are careless about their food intake. They just eat whatever they want or whatever satisfies their tummies. They’ll stay in front of computer and manipulate their accounts in social networking sites for such a long time and forget to have an active lifestyle outside. Humans don’t mind if they sleep or not. Some don’t like analyzing or mind challenge because they are too bored to think. They don’t socialize that much because it will only be a hindrance on what they do. If this cycle continues, it wouldn’t be shocking that most of us can’t remember a single thing anymore. Before it become worse, we must enhance our memory as early as we can. Enhancing it will be a good prevention for memory loss. It will benefit not just us, but also the other people around us. Enhancing our memory will help us in every simple way as much as possible.

Memory enhancement might not matter now, but we will realize later that it is a great investment for future. Considering the factors of memory enhancement like eating healthy foods and regular intake of vitamins, doing exercises, implementing good sleeping habits, and even socializing will result to a healthy remembering. When we take an examination, we think carefully of the answers. We know the answer a while ago but we forgot it just now. We need to take down notes or a memo but the pen went missing. We keep looking for it but it is just behind our ear. Isn’t it frustrating to experience these situations? It won’t be impossible to happen if we don’t enhance our memory, now.


Review of Literature

Memory plays an important part in our daily lives. It is involve in remembering faces, numbers, directions, facts and a lot of information we gather. Just like our body, our memory also have needs in order to live and do its purpose. Memory loss is so common these days. In order to improve our memory’s performance, we must consider taking care of our health, implementing good habits and often socializing. If it is used, it will continue to improve throughout your lifetime (Buzan T., 1991).

According to (Eastway R., 1991), one thing that is fundamental to a good memory is the health of the brain in which it sits. If our body needs good diet, so does our brain. There are kinds of food that will help us in improving our memory. One example of that is fish. Oily fish is the top scorer in foods that contain Omega-3. Fish also contains a fatty acid called DHA, which increases the levels of acetylcholine, a vital carrier involved in the memory’s function. Another one is food that contains anti-oxidants. Some people are unaware of what they take. There are some toxics that we unconsciously eat that can cause fundamental damage in our bodies, including our brain which is mainly responsible for our memory. Carbohydrates from bread and cereals can help to improve alertness, and the ability to form new memories and to retrieve the old ones. We are physiology different from each other, and what benefits in one person will not necessarily be the same for each one of us. Fish, anti-oxidants and carbohydrates will boost an average memory performance. The newest or the modern way to enhance our memory nowadays is taking up drugs. It can help but we must be careful in differentiating memory boosting drug and drugs that don’t retrieve old memories.

If we were really good thinkers, (


Gordon B. & Berger L., 2003) states that we won’t neglect mental workouts. Jigsaws, crosswords and Sudoku are can be seen in the newspaper every day to entertain us. Behind those sheets are ways for an alert and smart mind. Regular mental exercises build ups the brain, same as how physical exercise builds muscles and strengthens the heart. Treating your body well can enhance your ability to process and recall information. Physical exercises reduce the risks of memory loss. Try to give your memory a workout, training it to keep it sharp (Harp T., 2003). After a long tiring day in school or office, a sleep is a must. When we sleep, we boost the capability of our brain in problem-solving and critical thinking skills. It is also an essential in learning new information.

We find it hard to remember something especially if we need to input too much information. Socializing can be one of the simplest memory techniques. According to Oscar Ybarra, a psychologist at the U-M Institute for Social Research (ISR), socializing was just as effective as more traditional kinds of mental exercise in

improving memory

and intellectual performance. Interacting with others can sharpen your memory because social interaction itself is challenging already because you have to deal with variety of people. If socializing isn’t your habit, it can’t affect you now but it will in the future.

One of the horrors of growing older is the certainty that you will lose memory and that the loss of vocabulary or incident or imagery is going to diminish your imagination (Eastway R., 2004). Memory is like a shadow. It will be always after us, but as soon as the darkness rose, it will fade away. Memory is a lifetime machine. It will continue to work for a lifetime as long as we take good care of it. Just like an ordinary machine, it needs to be maintained to function properly.

According to Matlin (2005), memory is the process of maintaining information over time

.

“Memory” came from the Latin word memorariandmemor, meaning “mindful” or “remembering”. Memory is our ability to encode, store, and recall information or past experiences with the help of the human brain. It is like a filing cabinet with a limitless capacity and speed. The work that our memory does widely depends on the owner: the humans. Scientific research has shown that the human brain starts remembering things 20 weeks after conception. In order to form new memories, information must be changed into a usable form through the process known asencoding

.

Once the information has been successfully encoded, it must bestoredin memory for later use. Most of this stored memory lies out of our awareness most of the time, except when we really need to use it. The retrieval orrecalling process allows us to bring stored memories into conscious awareness and use it in the present.

Memory relies largely on the cells in our brain, and as we get older, brain cells (neurons) die, and don’t get replaced. The number of connections between the calls (synapses) also tends to disappear with age. We typically have 100 billion neurons at the age of eighteen, but then proceed to lose them every day thereafter. Forgetting is a normal and inevitable part of the way that the brain works at any age. One benefit of forgetting is that it helps to remove unnecessary information from our minds. The brain is good at knowing how to forget information that it no longer needs. It is hard to know which would be worse- never being able to remember, or never being able to forget. Forgetting may be a natural part of how the brain works, but not all forgetting is beneficial. It’s frustrating not being able to remember all those things that you actually do want to remember. Forgetting happens most of the time for office workers, students, teacher or anyone, even those who don’t have a profession. No one wants it, but just like what is stated above, it is inevitable. Many people wish to improve it, but some of us become unconsciously careless. One thing that is important to a good memory is the health of the brain in which it sits. We want to keep our memory alive but we are the ones who are killing it. There are some factors on killing your memory. Trauma to the head can permanently damage brain cells. Players that involve their heads on a physical game are more prone to brain diseases. Another step is intoxication. Alcohol is the most available substance for this. It slows down the brain’s function when it is in the blood. The third way to decline the brain is to ignore it. The phrase ‘use it or lose it’ really does apply to the brain. Lastly, the food that you eat is very important for the brain. A diet of burgers and highly salted chips is probably the best combination for brain decay, because it avoids feeding the brain the nutrients that help it to function.

Memory improvement is significant on someone’s lifetime. What’s the use of a happy event if you can’t recall? What’s the use of reviewing for exams if you have poor memory? As we grow older, we worry about how we will remember a particular thing, if there’s something we can do to prolong it. Well, worry no more! There are plenty of things we can do to improve our ability to remember things, but of course it requires effort from the people who wants it. There are some particular foods and vitamins that are helpful for memory improvement. The nutrients we get from it are responsible for the health of our brain. Exercises, physical or mental, will train our memory to be sharp. Lastly, as we socialize, the effect it gives in our memory is positive. Most of it was done in our daily lives. Enhancing our memory is very simple right?

Eating well is good for your physical as well as your mental health. The brain requires nutrients just like your heart, lungs or muscles do. Like everything else in your body, the brain cannot work without energy. But which foods are particularly important to keep our memory happy and healthy? There’s no doubt that diet plays a major role in brain health. Omega-3 fats that can be found on oily fish as DHA (if you have higher levels of DHA in the blood, then the brain will operate more efficiently), which enables the body to use it easily. If you’re allergic to fish, you don’t need to worry because there’s a good alternative like linseed (flaxseed) oil, soya bean oil, pumpkin seeds, walnut oil and soya beans. They are good for healthy brain function, the heart, joints and general well-being. Nuts and seeds are also on the list. They all contain another important antioxidant: vitamin E. In one study, researchers found that people who consumed moderate amounts vitamin E—from food, not supplements—lowered their risk of Alzheimer’s Disease by 67%. Here’s for all the sweet lovers- chocolate. Sweeten your brain-boosting diet with the dark kind (at least 70% cocoa); it contains flavonoids, another class of antioxidants that some research links to brain health. Let us all become healthy by eating veggies. Vegetables don’t just help our body to become healthy, but also our minds. Getting adequate amount of vegetables, especially broccoli, cabbage and dark leafy greens, may help improve memory. Can your diet make you smarter? You bet. Research shows that what you eat is one of the most powerful influences on everyday brain skills. So why don’t we try switching into a good diet? You’ve become healthy not just by body, but also by mind.

Some people wonder if a tablet can really help boost a memory. Whether you suffer from Alzheimer’s disease or you just have memory problems, it’s been said that certain vitamins can help or prevent memory loss. There is no miracle cure for a bad memory, but there is still a way to improve it while it’s not yet bad. Research shows that B vitamins improve memory by creating a protective shield for the neurons in the brain. B vitamins break down homocysteine, which is an amino acid that poisons nerve cells. This vitamin also aid in the production of red blood cells, which carry oxygen, an important brain nutrient. Known for its ability to cross the blood-brain barrier, this amino acid, Acetyl L-Carnatine (also known as ALCAR) helps with energy production necessary for optimal brain function. Another thing is Gingko Biloba. This herb has been shown to improve blood flow to your organs including your brain. Research concerning its effectiveness is mixed, though some studies indicated it may improve concentration. Unfortunately, much of the evidence for the popular cures isn’t very strong.

Leaving the foods and vitamins aside, let’s check how our habits can help nor destroy our memory condition. Physical fitness and mental fitness go well together. People who get regular exercise also tend to stay mentally sharp in their 70s and 80s. A study from Case Western Reserve University School of Medicine concluded that individuals who exercised – by walking or by engaging in physically active hobbies had a lower risk for Alzheimer’s disease. So experts recommend that you build physical activity into your daily routine. Exercising in the morning before going to work not only spikes brain activity and prepares you for mental stresses for the rest of the day, but also produces increase of retention of new information, and better reaction to complex situations. Let’s just consider exercise as a drug. It can be good if is intake moderately. Most of the people believe that memory fades with age. Well, newsflash: it’s just partly true. Memory fades away because as we age, because we lower the activities in involving it. Increase our brainpower by doing mental exercises. Crosswords and Sudoku and variety of board games are proven to improve our memory’s condition. As we play these games, we’re like settling our memory in a battle field to train, and be strong. As long as we live, we must not stop learning. Although people vary widely in their individual sleep needs, research suggests that six to eight hours of sleep a night is ideal to improve our memory. Our memory gets tired too. Findings suggest that getting an average amount of sleep, may help maintain memory in later life. Both too much and too little aren’t good. Aim for the right amount.

Social interaction is a key ingredient—along with proper nutrition,

physical exercise

,

brain training

, and

lifelong learning

—in the recipe for cognitive sharpness. Socializing can be a challenge for people who live alone, but everyone must have a social life no matter where they live or how they feel. You don’t have to have numerous social events on the calendar or go to a party just to socialize. Simply talking to them is. Being with other people is good for your health and also for your memory. We’re not meant to survive alone. Relationships stimulate our brains—in fact, interacting with others may be the best kind of brain exercise. In one recent study from the Harvard School of Public Health, for example, researchers found that people with the most active social lives had the slowest rate of memory decline. This won’t be a hard thing to do since we’re talking in our everyday lives. Isn’t it simple?

discuss elements of Property Law.

discuss elements of Property Law.

 

 

Order Description Dear Australian Writings, The three questions for t5000 word assignment appear below: Question 1. John comes into your law practice for advice. He tells you of the following series of events: He states that he owns property in a town called Mermaidland, a town in Queensland. Some building and construction is occuring at the location. He is having renovations done to both the Commercial premises and the granny flat attached to it. The commercial premises is let, for a period of three years to bait and Tackle Pty Ltd under a written lease. The granny flat is let to cousin Jack. There is no written agreement in place. The Bait shop has continued to trade, with some areas roped off with signs stating Keep Out Construction Site whilst John has moved out due to Workplace Health and Safety concerns. As construction continued an amazing thing happened. Bill, a workman employed by the builder, Hard Constructions Pty Ltd found a gold bar under a concrete slab that had been removed and was to be relaid. Another gold bar (but damaged) was located behind a lose brick in the storeroom wall. Both thfinds were made in the Bait shop. Ben, a subcontractor (not employee of) Hard Constructions Pty Ltd saw Bill surprise find. Ben immediately and thoroughly searched the residence. Ben found some more gold bars sitting on the coffee table in Jacks lounge room. It appeared like the bars had been extracted from the ground under the house. The floor boards next to the coffee table had been prised up. Ben found a final lone gold bar on a steel beam above the window in the main bedroom. John was inspecting the works on the day, and upon hearing the commotion, he immediately snatched the two bars from Bens hand. Upon hearing that Bill had found something as well John took all the bars which he had collected and added them to the ones he located in an unlocked toolbox on the back of Bills work ute which he sneakily searched. John immediately dismissed everyone from the site and claimed all the bars were his. Tfind had become so news worthy in Mermaidsville that the local news service had set up a live cross, which included a mobile camera platform which could be elavated and lowered to enable a view of the property over 10 foot high colour bond fence. John wants tinvasion of privacy to stop. Further John has received letters from legal representatives of Jack, Bill, Ben, and Bait and Tackle Pty Ltd and the Queensland Government, claiming all or some of the gold bars. John gives you the gold bars for safe keeping in your safe. They are of value. He wants to keep them all. Provide a short description of the property in tscenario and its relationship to each person. In 3500 words discuss Johns position in relation to the legal claims against him. You are a property lawyer confine your answer to the law of property unless some other matter is necessary in your discussion. Question 2 Modules 1, 2, 3 and 4 of the course discuss elements of Property Law. Now consider the law under sections 10, 12, 14 and 22 (other sections may be applicable) of the Personal Securities Act 2009 (Cth). Is the Act consistent or inconsistent with the common law principles set out in the common law fundamentals in tcourse. Discuss any major differences or issues which may present. Cite case law where relevant. You must correlate the two bodies of law in relation to property in your answer. Question 3 Merle comes to you with questions about clauses in her wil. You are a new expert property lawyer and she wants a written response. Merle draws your attention specifically to Clause 10 which says: Upon my death, I Merle GwenJorgensen, direct my trustees to hold my stock market share portfolio UPON TRUST for the children of my sons in equal shaas Tennants in Common. My said grand children must agree on the operation of that stock portfolio and if they do not, then my trustees may decide any issue that shall be binding. Clause 10 of the will contains a clause called a residuary clause which provides that if any gift in the will should fail, then that gift should be paid to all of Merles children (a son and two daughters) equally. Merle tells you that she has had a falling out with her son over lack of commitment to settling down and further she does not want him to benefit from Clause 10 via clause 12. He is unmarried and has no children. Assume Merle has had independent success planning advice and you only nto advise on Property related matters. Provide statutory references for any of your opinions where relevant. I can provide additional resources for questions when requested. Paper needs to use Australian Guide to Legal Citation referencing. I do not have a home phone. Thankyou Currently 1 writers are viewing torder

Infection control

“Explain And Evaluate Whether Or Not Infection Control Can Ever Be Manageable”

This assignment will explore the importance of infection control within nursing. In order to do this, it is first necessary to determine the term ‘infection’ and ‘infection control’. Then a discussion of the chain of infection will be highlighted, making links and referring back to recent clinical practice. There are six links to the chain of infection; the infectious agent, the reservoir (the altering environment), portals of exit (wounds and bodily fluids), means of transmission (different surfaces and airborne), the portal of entry (wounds) and the susceptible host of infection (Horton & Parker, 2006). If at any stage, the chain of infection is interrupted by an opposing agent such as alcohol hang gel, the chain will become broken.

“Infection occurs when an infectious agent multiplies within the body tissues causing adverse affects” (Walsh, 1997, p.102). When an individual has an infection, micro-organisms enter the body through a susceptible host, meaning that the infection will manifest within the body.

“A pathogen is a disease producing microorganism. These organisms which cause infections in humans include bacteria, viruses, fungi, protozoa and parasitic worms” (Brettle and Thompsom, 198, p6).

A human body continuously functions throughout life. Unfortunately, it is often only noticed when it fails. The defences start at the point of contact with our environment through which organisms may invade, for example the skin. Perry states that “The first line of the immune response is protection against invasion from micro-organisms. This is achieved by the skin, mucous membranes, secretions and excretions” (Perry, 2007, p 33).. These microorganisms must overcome any resistance mounted by the host’s defences in order for them to multiply and develop. “The human body is protected from infection by an immune system that have non-specific responses, which includes a number of mechanisms that provide general protection against infection” (Perry, 2007, p 32).

Infection control is “evolving rapidly, with the quality as the main focus of the service”. (Horton and Parker,2001, p 6). In light of this, it is also important to understand how “prevention and control of infections are important concerns for all types of healthcare agencies” (Craven & Hirnle, 2009, p 465). As health care professionals, working within environments which are highly prone to infectious diseases makes us highly sustainable to contracting a number of illnesses. Whilst on clinical placements, it is important that all ongoing policies and procedures are adhered to in order to minimise the number of infectious agents contracted by patients and health care workers. With a current epidemic outbreak of the influenza A H1N1 bug, also publically known as ‘swine flu’, the department of health established a campaign called ‘catch it, bin it, kill it’. It is a campaign which aims to prevent the spread of infection by making individuals aware of what to do if they cough or sneeze in public “Always ensure everyone washes their hands regularly with soap and water, clean surfaces regularly to get rid of germs, use tissues to cover your mouth and nose when you cough or sneeze and place used tissues in a bin as soon as possible” (NHS Choices, 2009).

Perry stated that “Standard infection control principles should be applied to the care of all patients, regardless of their infection status. These principles are aimed at preventing infection both to patients and to health care workers” (Perry, 2007, p66). A way this could be successfully achieved is to use universal precautions within health care settings.

There is a possibility to intervene and break the infection cycle through infection control procedures and lessen the likelihood of a patient’s susceptibility. It is cited that “a thorough understanding of the chain of infection helps health care professionals to deliver safe care and in turn enables appropriate measures to be taken in order to prevent transmission of infection” (Wilson, 2001, p70).

As previously stated there are six links to the chain of infection. The first two, being the infectious agent and the reservoir (the source of organisms) are closely related to each other because depending on what the environment is like, an infectious agent will always be able to survive in such conditions. The next three stages of the chain of infection can also be grouped together; these are the portals of exit (source of exit for the micro-organisms), the means of transmission (how the organism is carried from the portals of exit) and the portal of entry (gaining entrance into the host). An example of these working together within a hospitalised environment would be if a patient sneezed, the organisms would be transported either on hard surfaces or airborne to a patient who has an open wound. The final stage of the chain of infection is the susceptible host (Horton & Parker, 2006). If at any stage, the chain of infection is interrupted by an opposing agent such as alcohol hang gel, the chain will become broken.

To understand the first stage of the cycle, the infectious agent, it is very important to understand about microorganisms, their microbial virulence, their transmissibility, their growth requirement and most importantly, their effects on the human body (Wilson 2001). Bacteria are usually unicellular organisms and can survive for long periods of time in certain environments. Their main responsibility is to reproduce and survive as long as possible. “Viruses are different from any other organisms in that they consist of a core of one type of nucleic acid surrounded by a protein shell called a capsid. Unlike bacteria, they don’t last very long outside of the environment. Once inside the cell, the virus takes over the nuclear control” (Horton & Parker, 2006).Infections develop because microorganisms capable of initiating an infectious reaction have found a favourable host.

After understanding the infectious cycle, the “reservoir” stage occurs. Hospitals are not the only place where groups of susceptible people congregate to receive care. Individuals in places such as nursing homes are equally compromised. Microbes are able to survive in almost every environment, meaning that these microbes can also live on the human body. This section looks at how people conduct their own hygiene routines, the cleanliness and storage of equipment and finally the water used for cleaning. “In order to break the reservoir link, routine cleaning is an integral part of hospital practice and helps to maintain a high standard of care. Not only does this mean routine cleaning of the environment, e.g. patients lockers, beds, baths and showers, but the cleaning, disinfection and sterilization of the hospital equipment” (Wright et al, 1995, cited in Horton and Parker, 2006). Relating this to clinical practice, patients should always try to conduct their own hygiene routines and if unable to, the health care professionals will do so for them. An example of this would be a patient who needed to be shaved. “Assisting your patient with shaving is an important element of caring for an individual’s personal hygiene needs” (Iggulden, 2009, p134).

If there is still no break in the chain at this stage, the chain will progress on to the ‘portals of exit’. Clinical waste could be disposed of in yellow bags, with all sharps disposed in the allocated sharps bin. “Disposal of used sharps in inappropriate places causes risks to others. These sharps should be disposed immediately, without re-sheathing. Once 75% full, these should be closed and secures off “(Wilson, 2001,p42).

The removal of urine, faeces and other bodily fluids also has to be conducted with great care. The use of linen could also cause a potential infection epidemic. Local laundering facilities are often encountered in many community elderly care units and some specialist wards usually for patients own clothes (Horton and Parker, 2006). Relating this to clinical practice, if a patient has a soiled bed, it is important to change and remove all linen appropriately in order to stop the spread of infection. “Every workplace has written policies on all aspects of waste disposal including special waste, segregation of waste and audit trails. A system of colour coding to identify segregation also exists” (Iggulden, 2009,p66).

The state of transmission (also known as direct contact acquired infections) refers to a susceptible host coming into contact with a person’s body surface or fluids who is infected. Some organisms can be transmitted by more than one route, either directly or indirectly. Direct contact involves proximity between the susceptible host and the infected person or a carrier such as touching, kissing or sexual intercourse. The indirect route requires personal contact with an intimate object, such as a contaminated instrument. Contaminated blood, food, water or inanimate objects are vehicle routes of transmission. With the use of alcohol hand gel on entrance into the ward, on walls throughout the hospital, in all of the toilets and shower rooms and at the end of the patients bed, this is one infection control step which most mobile individuals can carry out. There are also posters above every sink demonstrating the appropriate way to wash and dry hands. These posters are also placed throughout the hospital, along with informative leaflets describing all of the different types of infectious diseases that are likely to be contaminated. “In 2004, the NPSA launched the ‘clean your hands’ campaign across England and Wales. This campaign helps provide practical support to health care organisations. It also involves education and development of an organisational culture where individuals take personal responsibility for delivery of safe, clean care”. (Iggulden et al, 2009, p65).

“Hand creams are another way of preventing infection. Frequent hand washing, especially with antiseptic solutions or if hands are not properly dried, can cause damage to the skin. Cracked skin may harbour more bacteria and increase the risk of cross-infection” (Berman et al, 2009,p222).

“Protective clothing is also a key to preventing the spread of infections. Many excretions and secretions of the body are a major source of pathogenic microorganisms associated with hospital acquired infection (urine, faeces, vomit, sputum, saliva, vaginal secretion, semen, blood, blood stained body fluids, tissues and cerebrospinal fluid)” (Perry, 2007, p33). Aprons or gowns should be worn for procedures anticipated to cause significant contamination of skin or clothing with blood or body fluid. “This will protect the skin of the healthcare worker from contamination by potentially infected body fluid and reduce the risk of cross-contamination of microorganisms to other patients on the clothing.” (Wilson, 2001, p142).

Gloves are also vital in order to constrict any infections from spreading. Disposable gloves for direct contact with body fluids and moist body sites provide a reliable method of reducing the acquisition on hands of microorganisms from these sources. “Gloves should be worn for any activity where body fluid may contaminate the hands”. ( Paterson et al, 1991, cited in Walsh 1997, p101). Gloves must always be changed between patients, even if they are being used for routine procedures such as emptying urine drainage bags. “Washing gloves between patients is also not recommended; the gloves may be damaged by the soap solution and if they become punctured unknowingly, may cause body fluid to remain in direct contact with the skin for prolonged periods of time” (Olsen et al,1993 cited in Wilson, 2001, p139).

Another preventative step, although commonly not used within the health care setting, is for individuals to wear masks and eye protection. Close fitting masks are recommended for some aspects of care of patients with open tuberculosis. Eye protection and masks should be worn for any activity where there is risk of bodily fluids splashing into the face. Tolkars et al (1995) found that contact between bloods or other infective fluids and the eyes or mouth of surgical staff occurred in 2% of surgical procedures, particularly orthopaedic and gynaecology (cited in Wilson,2001, p141-42).

In order to avoid these examples being contained by patients, it is sometimes necessary to put the patient into an isolation room. To avoid such contamination, it is absolutely crucial that all equipment is sterilized.

If there is still no break in the chain, the portal of entry stage arises. This is the entry route which organisms find their access into the body. This entrance is often the same as the exit route. Some common entry routes are the urinary, respiratory and gastrointestinal tracts (Taylor et al, p504, 1993).

Intact skin protects tissue from invasion by microorganisms. Damaged skin may become infected superficially by bacteria or fungi and blood borne viruses which may enter the body through damaged skin, hence why cuts on the skins surface need to be covered.

In order to avoid organisms getting into wounds, it is essential that the correct safety equipment is used. (Horton and Parker, 2006). Whilst on a recent placement, a sterile pack including sterilized gloves, scissors and swabs were used to change a head dressing. This was to ensure that no organisms could enter the patient’s most vulnerable sight causing infection.“The susceptibility of the host is influenced by various different factors including normal PH levels of gastric secretions, age, sex, race, hereditary factors, immunization, fatigue and high stress levels’ (Taylor, Ellis et al,1992). Wilson added “the sustainable host can essentially be anyone, depending on their health and well being at that one time, whether they are patients, visitors, other health care professionals, friends or family members. It is also essential as a health care professional, to recognise that certain microbes may not be harmful to a healthy individual, but may overwhelm someone who is unwell and that the susceptibility of the host varies, depending on their immune defences” (Wilson,2001, p65). When a chemotherapy patients has treatment, their immune system lowers, making them more susceptible to infection. The immune system of a baby would be immature of that compared to an adult; similarly, an elderly patient’s immune system would be significantly lower in efficiency. “Adequate nutrition is also essential to encourage rapid wound healing and thereby reduce the possibility of wound infection” (Wilson, 2001, p191). Within a clinical placement, assisting a patient with a good nutritional intake would boost their immune system by giving the body all of the additional vitamins needed to recover from its trauma.

To conclude, everything which was touched upon in the introduction was explored throughout the text, with the main focus of the assignment exploring the chain of infection. I discovered how the six stages of the chain of infection may be applied to individuals who are susceptible to infection. In order for me to do this successfully, I related each of the stages back to clinical practice. This allowed me to develop a greater depth of knowledge as to how infection can be eradicated within hospitalised environments. In clinical areas, cross infection will always be an issue for any hospital, regardless of how many policies and procedures there are in place. It is impossible for any trust to ensure that each individual who walks into a clinical area follows the preventative measures to eradicate infection. Wilson summarises “infection is a common, but largely avoidable complication of healthcare” (Wilson, 2001, p131). With patients, health care workers and domestics all having different levels of knowledge concerning infection control, the way people conduct themselves in certain environments will always differ. Health care workers can ensure they practice professionally, for example partaking in the NHS campaign “Bare below the elbow”, and is good practice to make sure that all workers in hospitals use all forms of prevention such washing their hands correctly, and using alcohol gel.

References:

  • A.Berman, C. Jackson, S. Snyder, 2009, Skills in clinical nursing, 6th edition, New Jersey, Pearson Hall
  • C.Hirnle, R. Craven, 2009, Fundamentals of nursing, 6th edition, United States, Lippincott Williams and Wilkens
  • C. Lillis, P. Lemone, C. Taylor, 1993, fundamentals of nursing the art and science of nursing care, JB Company
  • C.Perry, 2007, Infection prevention and control, Oxford, Blackwell
  • H. Iggulden, C. MacDonald, K. Staniland, 2009, Clinical skills the essence of caring, London, Open University
  • J. Wilson, 2001, Infection control in clinical practice 3rd edition, London, Bailliere Tindall
  • L. Parker, R. Horton, 2006, informed infection control practice, London, Churchhill Livingstone
  • M. Thompson, R. Brettle, 1984, Infection and communicable disease, London, Heinemann
  • M. Walsh, 1997. Watson’s Clinical Nursing and Related Sciences 5th edition. London. Baillere Tindall
  • NHS UK [Online] [accessed 08/01/09] world wide web: < http://www.npsa.nhs.uk/cleanyourhands/the-campaign/whoglobalchallenge/>
  • NHS CHOICES UK [Online] [accessed 03/08/09] world wide web: < http://www.nhs.uk/AlertsEmergencies/Pages/Pandemicflualert.aspx>

Theories and Principles Of Leadership And Management

Leadership is said to be a way of behaving that influence others to respond, not because they want to, but because they have to, it is seen as personal interactions between group of people which aim at improving personal interactions and focus on achieving a particular goals. Catalano (2006), define leadership as the ability of and individual to influence the behavior of others. A good leadership must possess some very important skills to be effective, this includes but not limited to critical thinking, problem solving, active listening, skillful communication, acknowledgment and respect for individual difference, establishment of clear goals and outcomes, and continue personal and professional development (Tappen 2001). While Management on the other can be define a problem oriented process with a focus on the activities needed to achieve a goal, it supply the structure, resources and direction for activities of the group. Management is aimed toward influencing employees to be as productive as humanly possible Catalano (2005). There is always a relationship between leadership and management in nursing, Malby (1996) indicates that developing and fostering leadership competencies could direct nurse managers to think beyond tradition and to coordinate multidisciplinary dialogue which articulates the needs of the system and the patients whilst empowering employee. Leadership has been defined by different scholars and it has been group into theory for better understanding of its relationship to management, in this essay I will concentrate on the effect of different leadership and management theory and how it is related to nursing and healthcare system.

Leadership theories

Relationship-tasks orientation and Management theory

Leadership and management

Leadership Theory

In authoritarian leadership style, the leaders maintain strong control over all aspects of the group and its activities, provide directions by giving others that the group are expected to carry out without questions (catalano 2006). This kind of leadership style should not be used in healthcare setting because of it negative influence on care giver, since healthcare is an interdisciplinary system in which group participation provide the best care for client and promote health. The mother of Nursing, Florence Nightingale has been said to use this style of leadership during her time. Her leadership and management style permeated nursing management for decades, and continued to dominate health care settings established and managed by the religious orders. Castigatory criticism, strong overt control, an ‘I’ and ‘you’ difference in status and a complete absence of individual consideration were the epitome of nursing management (Marquis & Huston 2000, Widerquist 2000). And this was also supported by Widerquist (2000) statement that whilst Nightingale may be considered a ‘Great Woman’ of the Victorian era, the undercurrents of her theories, ideologies and management style have had deleterious consequences for subsequent nursing practice and nursing management. Carney (1999) asserts that whilst evidence suggests that this approach is still employed in some health care settings, the autocratic leadership style should only be utilized in crisis situations.

In Democratic style theory (Supportive or Participating), all aspects of the process of achieving a goal, from planning and goal setting to implementing and taking credit for the success of the project, are shared by the group (Catalano 2006). This allows members participation and control because of its freedom of expression altitude toward achievement of goals. Murphy (2005) stated that Democratic leadership is supportive of group interaction and decision-making. Staff is motivated by economic or ego awards and supported by direction and guidance.

Laissez- Faire leadership Style is also describe as permissive, non directive, or passive. The laissez-faire style leader allows the group he or she is leading to determine their own goals and the methods to achieve them. There is little planning, minimal decision making, and a lack of involvement by the leader (catalano 2006). The laissez-faire leader observes followers working from a distance and does not tend to intercede unless necessitated (Mullins 1994). Because of the leader little control and authority which can lead to variable efficiency and quality of output it is not commonly used in healthcare setting. Marquis and Huston (2000) caution that if this style of leadership is used inappropriately, it can precipitate apathy and disinterest in staff and a frenetic department.

Transformational theory recognizes that multiple intangibles exist whenever people interact. Factors such as sense of meaning, creativity, Inspiration, and vision all are involved in creating a sense of mission that exceeds good interpersonal relationships and reward. In many healthcare facilities, nursing leaders are expected to inspire excitement and commitment in nurses, who often must provide care to very ill clients in less than ideal circumstances (catalon 2006). Transformational leaders strive to elevate the needs of their followers which are congruent with their own goals and objectives through charisma, intellectual stimulation and individual consideration (Bass et al.1987a).

Leadership orientation and Management theory

In High Relationship- Low Task Orientation the leaders are usually well liked by the groups because of their acceptance of the group members as individuals, consideration of their feelings, encouragement, and promotion of good feelings among all the group members (catalano 2006). This relationship focuses more on the employee to elicit the high production ,and was supported by Human Interaction theory (management theory) in which management were required to develop a different set of management skills, including understanding human behavior, effective counseling , increase motivation using effective leadership skills and maintaining productive communication (catalano 2006). In Nursing, this relationship helps to get the best out of the health care team thereby increasing the quality of care giving to patients. These theories was also supported by the Michigan studies on the leadership behavior(Cole 1999) in which it reported that supervisors of high producing groups tended to be employee-oriented and exercised employee participation in decision making, thereby promoting team development and cohesiveness.

High Task-Low Relationship describe a leader who does all the planning with little regard to the input or feelings of the group, gives order and expect them to be carried out without questions (Catalano 2006). This can be related to Time-Motion Theory (management theory), define as planning, organizing, commanding, and controlling the work of any particular group of employee (Catalannn2006). This can create a non productive environment if use in the health care setting because of it decrease in employee satisfaction. The Michigan studies (Cole 1999) conclude that the supervisors of low producing groups were task oriented and consequently were referred to as production-oriented leaders. These leaders focused more on the tasks than on the employee needs and tended to strictly monitor and control performance.

Leadership and Management

Leadership orientation and theory are used interchangeably, since environments and situations are constantly changing in healthcare settings. Factors such as member skills, the circumstances or problem at hand, the work environment are put into considerations. Fiedler (1967) identified the leader’s power; the leader-follower relationship and the task to be accomplished as the key variables which determine the particular leadership style required to militate various problems in diverse situations. Hence, the applicability of Fiedler’s (1967) leadership theory to contemporary nursing management is conceivable, as various approaches can be employed interchangeably to manage diverse situations. For example the authoritarian leadership is mostly used in emergency situations in which saving a life and obtaining maximum health is the highest goals of any group. And this is supported by Carney (1999), who asserts that whilst evidence suggests that this approach (authoritarian theory) is still employed in some health care settings, the autocratic leadership style should only be utilized in crisis situations. Catalano (2006) stated that a nurse manager on a hospital unit may use a highly democratic style in most of the routine activities of the unit, but when a client goes into cardiac arrest, she may revert to a highly authoritarian style while directing the staff through a code. Also in quality management, where the problems are often long term and complicated, the leader tends to be a nurse who is well organized and methodically sift through a mountain of information and statistics to develop a policy that covers the widest range of possibilities.

It can be argue that to be an effective manager, it is apparent to have the quality and highly develop skills of a good leadership, especially in healthcare to achieve optimum health and increase productivity. Whilst one does not have to be a leader to manage and a manager to lead, researchers in the 1960s began to recognize how these skills can be intertwined and employed synonymously to realize organizational goals (Marquis& Huston 2000). It could also be argued that unless managers are cognisance and competent in strategic planning development, which implicates on clinical practice, their efforts may be circumvented by more senior levels. In addition, to affect successful change management in a constantly changing environment, the nurse manager must be appropriately prepared to lead and manage the complexities and contingencies of this process (Dutton et al. 1997). Management and leadership skills complement each other, it can be learned and require practice and experience.

The Heart- Hands and the Mind in Midwifery

The Art of Midwifery

Midwifery places the woman and the midwife at the centre of midwifery care. It is said that midwifery is an art that uses the heart, the hands and the mind. In relation to working with woman in childbearing this essay will discuss this statement. The essay will look at these three essential elements of midwifery, the heart, the hands and the mind, showing detail of how each are related and the importance of each element when working with women in childbearing. The ‘heart’ looks at the key values of compassion, respect for the women, the baby and oneself, and the importance of women centred care. The ‘hands’ focus on the skills, techniques and therapeutic touch of the midwife and the ‘mind’ highlights reflective and ethical practice, and the knowledge required to practice safely and competently.

The Heart

At the heart of midwifery practice is the relationship between the midwife and the woman. This involves a relationship of trust. The women, relies on the midwife to give her confidence. The midwife is trusted by the woman to know what is best for herself and her body. The midwife benefits the childbearing woman with clinical knowledge, skills and recommendations, forming a relationship of mutual trust and respect (Alef Thorstenson, 2004). The mother and the baby are the central focus for the midwife.

Pelvin (2006) describes the midwife’s role as one of privilege. The intimate relationship between the midwife and the women exists, through a personal and momentous event in the life of a woman. The physiological procedure of birth and the post natal relationship between mother and baby is facilitated by the midwife however the midwife’s influence does not end there, the role attempts to assist the women to have a deeper understanding of herself and of her family relationships. A fundamental value of midwives as stated in the (Australian Nursing and Midwifery council [ANMC] Code of ethics, 2005) is the value of kindness and compassion to others and self, by respecting the fundamental rights and choices of the mother and ensuring that practice is ethically and culturally appropriate. Acts of kindness such as being gentle, considerate and caring should be a constant approach to midwifery care.

The art of midwifery involves achieving a balance between being competent and professional whilst showing heart by still demonstrating emotion. Hunter (as quoted in Jacob and Lavender, 2008, p. 78), says that “…expressing emotion and sharing feelings with others is immensely valuable, both for enhancing relationships and also for developing a type of practice that is open-hearted and genuine.” This relationship is extremely valuable with pregnancy outcomes which may involve unexpected miscarriage, where supporting women and their families can be difficult.

The Hands

The ‘hands’ in the art of midwifery looks at the benefit of therapeutic touch. Therapeutic touch can reassure the woman of her safety with the knowledge that her midwife is confident in her actions and sensitive to her needs. When situations do not allow words, the hands can convey reassurance and express confidence, compassion and care (Ernst, 2009). Touch can be used in many forms including close contact for physical support, helping the women to maintain her posture or just being there as a shoulder to lean on. Touch can provoke different responses by different women. While massage can be good for relieving pain for some, others find a simple light touch to the forehead is all that’s needed to reassure a woman she is not alone and that the midwife is there for her (Page & McCandish, 2007).

Another important ‘hands on’ skill for the Midwife is the ability to use palpitation and touch examination of the mother’s abdomen to assess and determine the baby’s growth, position, size and wellbeing (Grigg, C. 2006). Other skills utilizing the hands can include, teaching breastfeeding, blood pressure measurement, supporting the women through labour and birth, baby assessments and supporting the newborn infant and the use of interventions such as epidurals.

The (Australian Nursing and Midwifery council [ANMC], Code of Professional Conduct for Midwives in Australia, 2006) describes many other midwifery skills not only relating to the care of the woman but also her family and the community. It is the duty of the midwife to provide antenatal and parenthood education. The midwife is committed to working with the women, providing support and advice during her pregnancy/birth and through the postpartum period. The midwives responsibilities also extend to preventative care, detections of complications, promotion of normal birth and accessing the need for medical intervention and the carrying out of emergency procedures should an emergency occur.

Creating a positive atmosphere and environment for the birth is an important factor for many women. Most women have their babies in the unfamiliar and unwelcoming environment of the hospital, a positive attitude assists in reducing anxiety and stress, allays fears and allows the woman to feel secure in her surroundings. Page & McCandish (2007) suggest that simply by making more space and moving furniture in the room offers the woman more area to move and by providing different props such as benches, pillows, and cushions give the women more choices so as for example she can lean or rock when experiencing the intense pain of contractions. The skills of the midwife are many and varied and the hands are vital in conveying messages to the woman.

The Mind

As the Australian College of Midwives, ACM Philosophy for Midwifery (2004) states midwifery is informed by scientific evidence, by intuition and by experiences. This involves the midwife using knowledge gained from research evidence, individual values and preferences, seeking out evidence to support decisions and discussions with the woman to decide on her individual birthing plan. Page & McCandish, (2007) describe evidence based clinical practice as “the judicious use of the best evidence available, so that the clinician and the patient arrive at the best decision, taking into account the needs and values of the individual patient.”(p.205)

Birth is a normal life event and not a disease process thus making health promotion the basis for midwifery care. Health promotion and education involves more than the provision of information to woman in antenatal classes lead by a midwife, where the midwife discusses topics the professional deems relevant. Education needs to move to a more client-led agenda (Beldon & Crozier, 2005).

When working with women it is important to always focus on women centred language and effective communication. Thinking and imagining how the woman is feeling assists in providing comfort and reassurance to the woman. Giving women information about the progress of the labour in positive terms that the woman will understand is most valuable. Knowing when to be quiet is also important. The midwife has to be mindful of her own facial expressions as these can have a huge impact on the woman’s feelings, a smile conveys reassurance that everything is ok and going well (Page & McCandish, 2007).

The midwife’s mind needs to be aware of the changes occurring in maternity care and know that the traditional medical model that once served the doctors and the hospital, is antiquated. As we move towards emerging midwifery models of care which favour continuity of mother and baby care by the same midwife throughout the women’s pregnancy, birth and beyond (Barlow, 2008). A midwife’s autonomy is increasing in maternity care. The Australian Nursing and Midwifery Council, Code of Ethics for Midwives in Australia (2005) also states midwifery care includes the promotion of ‘normal’ birth, prevention and detection of complications in the mother and baby, medical care access and the carrying out of emergency measures as important responsibilities of the midwife.

Conclusion

The heart, hands and the mind all play important roles in the midwifery model of care. Each area can be difficult to explain as separate components of midwifery as the three areas are intertwined and each just as valuable as the other in providing women with women centred care throughout the life changing experience of childbirth. It is evident from research into the art and science of midwifery that midwives are essential in providing care to the childbearing women that supports and guides women through healthy pregnancy, labour and the postpartum period. Midwifery care involves the promotion of ‘normal’ birth, prevention and detection of complications in the mother and baby, medical care access and the carrying out of emergency measures. Our role is to work in partnerships with women and their families by helping them to explore their options and make informed decisions.

WORD COUNT: 1440 words with in-text referencing.

Benefits of Birth Defects Research: Case for Studying Environmental Factors

Introduction

Most human diseases have a genetic component. For some, a genetic alteration is the primary or direct cause. In this category fall chromosomal conditions, which are due to a change in the number or structure of chromosomes, affecting many genes (e.g., trisomy 21) and monogenic or Mendelian diseases, due to the presence of pathogenic variants in a single gene (e.g., cystic fibrosis).

In other conditions, genetic components play either a predisposing or protective role which, whereby interaction with each other and with environmental factors, give origin to what are known as complex or multifactorial diseases (examples include congenital heart disease, obesity, diabetes, etc.)

It is estimated that approximately 6% of all live births have a serious birth defect. (Christianson, 2006) If this is the case, then diagnostic and treatment interventions (e.g., diet supplementation, antiviral treatments or gene editing techniques) could benefit almost 8 million children worldwide every year (Savulescu, 2015).

An argument used against Birth Defects research is that

in vitro

fertilization, pre-implantation genetic diagnosis (PGD) or termination of pregnancy can ensure that only healthy children are born: You just need to create multiple embryos, do PGD and select disease-free embryos for implantation. However, the argument does not hold. PGD cannot rule out complex multi-genic diseases or common dispositions, even radically increasing the numbers of embryos a couple produces (Bourne, 2012).

Another flaw in the argument is that it lacks to consider the role of environmental factors and infections acquired

in-utero

or during the birth process, a significant cause of foetal and neonatal mortality and a known contributor to birth defects. Unfortunately, the affected newborn infant may not show any signs until later in life, making the diagnosis even harder.

In the following essay, I will exemplify how the study of environmental factors that can lead to birth defects has furthered our understanding of normal human embryonic development and of the pathogenesis of congenital anomalies, while it has helped to improve clinical diagnosis, prognosis and the development of preventive and therapeutic strategies.

Environmental factors

Discrete environmental factors that can have an effect over the intrauterine environment and the human embryo development are sometimes referred to as “maternal” factors, to differentiate them from genetic aetiologies. The impact these factors can have over foetal or neonatal morbidity and mortality will depend very much on the specific period of the development in which they present (Moreau, 2019).

Bacteria, viruses and parasites can be transmitted from the mother to the foetus or newborn, what is known as “vertical” transmission, and can cause serious to both mother and child. The acronym “TORCH” (

Toxoplasma gondii

, other, Rubella virus, Cytomegalovirus and Herpes simplex virus) is still misleadingly been used to refer to a foetus or newborn who presented clinical features compatible with a perinatal infection (Schleiss, 2018).

The contribution of infectious diseases and teratogens to birth defects is well recognized (Figure 1.). Hence, many screening recommendations using serology or PCR tests during pregnancy have been published. Less than 1% of birth defects attributed to teratogens seams negligible.  However, almost 80% of birth defects still do not have a known aetiology. Congenital infections and teratogens research might shed a light on these cases with non-recognised origin.

It has been shown that prenatal exposures to teratogens and microorganisms can affect the epigenetic machinery (histone modifications, DNA methylation and non-coding RNA expression) responsible for gene and protein expression. These dysregulations can result in foetal death, dysmorphic features or developmental delays. (Aref-Eshghi, 2018).


Figure 1


.

Known and unknown aetiologies of birth defects. Modified from Marcia L Feldkamp et al. BMJ 2017; 357.

Shepard’s Criteria

Historically, two approaches have been used to identify potential teratogens, defined as “exposures to a mother during pregnancy that have a harmful effect on her embryo or foetus” (Rasmussen, 2011):

a)   The ‘rare exposure – rare defect’ combination (also referred to as the “astute clinician approach” (Rasmussen, 2011).

b)  Epidemiologic studies data

Congenital Rubella Syndrome and Foetal Alcohol Syndrome are examples of the ‘rare exposure – rare defect’ approach, identified respectively after an ophthalmologist noted cataracts in an infant whose mother had had rubella during pregnancy (Dudgeon, 1967) and after heavy alcohol use during pregnancy was linked to a characteristic pattern of malformations (Hanson, 1978).

On the other hand, Valproic Acid was identified as a teratogen after a case – control study showed an odds ratio of 20 for the association of

Spina bifida

and the use of Valproic Acid during pregnancy) (Tomson,  2016).

In 1994, a set of seven criteria that incorporated both approaches was proposed for “proof” of teratogenicity (Table 1.). These criteria are still in use to guide teratology – related litigations and to assess new potential teratogens (Schachtman, 2016).


Table 1.

Criteria for Proof of Human Teratogenicity. Adapted from Shepard, T.H. (1994) “Proof” of human Teratogenicity. Teratology 50: 97-8.



Understanding human embryonic development: Organoids to study teratogens.

The study of compounds that can cause foetal toxicity have provided valuable information related to embryogenesis and pushed forward the development of new technologies. Specifically, the technical and ethical problems that apply to human development modelling led to the creation of organoids (3D organ-specific models).

The recent Zika virus outbreak dramatically increased the prevalence in microcephaly, particularly in Latin America (Wheeler, 2018). Since the outbreak, many groups have used neural organoids to examine the effect of the Zika virus on neural development. To evaluate the differences of the organoids to

in vivo

neural tissues required the assessment of organoid size (Cugola, 2016), apoptosis markers (Cui, 2016), immunostaining (Xu, 2016) and transcriptional analysis (Di Lullo, 2017).


Figure 2.

Cortical alterations in human brain organoids infected with ZIKV. From Cugola et al.

Nature

534, 267–271 (2016)

In the process, human iPSCs were shown to be able to generate motor and glutamatergic neuron-specific organoids (Farkhondeh, 2019). At the same time discrepancies in the organoids assessment results led to the acknowledgement of hESC derived cell types pertinent to neural development (Srinivasan, 2019).

Teratogenicity studies have also contributed to the progress in heart, kidney and retinal organoids development. Cardiomyocytes derived from hPSCs have been used to evaluate the effect of different drugs on contractibility and to visualize markers by immunostaining (e.g., MLC2v, Ki-67, and a-actinin) (Friedman, 2017). Using organoids as a testing platform helped to ascertain that the metabolic switch to fatty acid oxidation that happens

in vivo

when using palmitate “facilitated metabolic, transcriptional and cell cycle maturation” (Mills, 2017).

Organoids allow evaluating and mimicking the later stages of development. It is pending yet the evaluation of a) the accuracy of these systems in mirroring organ development, b) the uniformity in organoid formation, relevant for high-throughput applications and c) performance of multiple organoids simultaneously (Nio, 2019).

Unfortunately, the most damaging effects of infections and teratogenic compounds are seen when the exposure occurs early during the first trimester of pregnancy. Since organoids do not adequately replicate early embryonic events, more recent studies have looked at culturing human embryos and have observed, among other thing, human amniogenesis when using hPSCs (Shao, 2017).

Embryo cultures brings up ethical questions, since toxicity studies require a large number of human embryos and the current 14-day rule gives no space for long-term studies.

Understanding the pathogenesis of congenital anomalies: Valproic acid (VPA)

VPA, a commonly used anticonvulsant drug, can cause major congenital anomalies in as much as 10% among the offsprings of women treated with the drug during pregnancy (Ornoy, 2017). The teratogenic mechanisms of action of VPA are multiple: Folic acid depletion, arene oxide toxic intermediates, enhanced oxidative stress and induction of gene expression changes (Volmar, 2015).

Folic acid deficiency may trigger changes in gene expression and protein synthesis and can increase oxidative stress (Ornoy, 2018). These changes can explain the wide range of congenital anomalies, including neural tube defects (NTD) and neurodevelopmental delay. VPA treatment in mice was used to show that during organogenesis changes in folate metabolism induced NTD (Akimova, 2017) and that homocysteine augments VPA induced exencephaly (Cabrera, 2018).

VPA can reduce Superoxide Dismutase (SOD) activity and glutathione levels (Ornoy, 2019a). It is suspected that VPA – induced oxidative stress is related to nitrous oxide (NO) production (Fathe, 2014). Sildenafil citrate, which inhibits the 5-phosphodiesterase that increases the action of NO, was found to reduce the rate of VPA – induced NTD in foetal mice (Tiboni, 2015).

Antiepileptic drugs like VPA generate toxic intermediates when metabolised by cytochrome P450 (Johannessen, 2010). Arene oxide, one of the toxic intermediates, can bind to macromolecules and damage embryonic cells. Epoxide hydrolase inactivates arene oxide. Therefore, a lower activity of the enzyme leads to higher concentrations of arene oxide, damaging the developing embryo and foetus (Kelly, 2018).

VPA can inhibit histone deacetylase (Göttlicher, 2001). Both, up and down regulation of gene expression has been described after VPA induced DNA methylation changes. Again, this can also explain the wide range of VPA-induced congenital anomalies, including an increase in autism rate (Eshraghi, 2018). Table 2 shows different developmental and regulation molecular pathways affected by VPA and Carbamazepine (CBZ), another antiepileptic drug.


Table 2.

Pathways significantly enriched after VPA exposure and/or after CBZ exposure, involved in neurogenesis or pharmaceutical mechanism of action, showing the total number of genes described within the pathway and the number statistically significantly regulated after exposure. From Schulpen, Pennings, and Piersma,

Toxicological Sciences

146 (2): 311–320 (2015).




Contributions to clinical diagnosis and prognosis. The case of “TORCH”.

Evaluation of a child with a suspected birth defect is usually triggered by the presence of congenital anomalies, sought pre or post-birth, growth abnormalities (high or low stature, body segments disproportion or unexplained obesity), mental retardation or developmental delay, loss of vision, hearing loss, a family history of consanguinity or a known inheritable condition running in the family.

In infants with a birth defect, many times clinicians need to rule out a congenital infection. The diagnostic algorithm must include an exhaustive review of the maternal and perinatal history, but more laboratory diagnostic tools have become available. This has led to an increased sensitivity and specificity in the diagnosis of congenital infections and an increase in the observed prevalence of perinatal infections. But it has also uncovered a wider spectrum of these diseases (Boppana, 2017), what relates back to the 80% of birth defects with unknown aetiology

A “TORCH” diagnosis can be difficult, since many of the infectious and non-infectious clinical syndromes that present in the immediate neonatal period overlap in their semiology. Furthermore, sometimes there is no evidence of the infection until years later, when it is too late for an intervention. Hence, early recognition, including prenatal screening, is key. Fortunately for many of the pathogens associated to congenital infections, like Herpes simplex and Cytomegalovirus, treatment or prevention strategies and national and international standards and protocols are already available.

In the case of Toxoplasmosis, most clinicians would take a ‘risk-based’ approach and test the newborn based on ultrasound described findings (i.e., hydrocephalus and cerebral, hepatic or splenic calcifications). Maternal screening includes serology and molecular biology testing. PCR of the amniotic fluid obtained by amniocentesis at 18 weeks’ gestation can confirm foetal infection and guide medical therapy.  Observational data suggest maternal therapy decreases foetal infection and the incidence of serious neurologic sequelae in the newborn (El Bissati, 2018).

There is no routine screening protocol for Parvovirus in pregnant women. Maternal symptoms, suspicious finding (i.e.,

Hydrops fetalis

) on routine or screening ultrasound or a known maternal exposure might trigger testing for the infection. Monitoring for

Hydrops fetalis

and anaemia is recommended for at least 12 and up to 20 weeks after exposure (Crane, 2014).

In utero

foetal transfusion is the treatment of choice. It targets the anaemia and subsequent foetal hydrops, reducing foetal death.

In the case of HIV, testing algorithms and prevention protocols have had a significant impact on perinatal HIV thanks to  the identification of maternal infection. Similarly, in the past women were screened for hepatitis B surface antigen (HBsAg) only if they fell into a high-risk group based on immunization status, history of exposure to blood products, intravenous drug use, etc. However, less than 60% of HBsAg carriers were identified using the screening criteria. Currently it is recommended that all pregnant women be screened for HBsAg at the first prenatal visit.


Teratogens and development of preventive or therapeutic strategies

.

Once the teratogenic mechanism of action of an environmental factor is known, different means of prevention may be elucidated.

There are some very effective examples of teratogenesis prevention strategies in humans:

  1. Rubella immunization before childbearing age – it has practically eradicated the Congenital Rubella Syndrome (Bouthry, 2014).
  2. Supplementation of folic acid can prevent a large proportion of neural tube defects. The Prevention of Neural Tube Defects by Inositol (PONTI) pilot study should provide evidence to further evaluate inositol for primary prevention of NTD (Greene, 2016).
  3. Prevention of mental retardation by table salt supplementation with iodine in iodine-depleted regions (Syed, 2015).
  4. Glycaemic control during pregnancy.
  5. Avoiding alcohol drinking during pregnancy.

Prevention of teratogenesis in experimental animals include:

  1. Folinic acid pre-treatment of VPA-exposed mice. It reduced foetal resorptions and skeletal malformations. Pre-treatment with vitamins B6 and B12 protected mice against VPA – induced exencephaly and kidney malformations (Ornoy, 2018).
  2. Prevention of Autism Spectrum Disorders (ASD) like behaviour in mice postnatally injected with VPA, using piperine and green tea extracts (Ornoy, 2019b).
  3. Positive results in hyperglycaemic rodents models by feeding them arachidonic acid, myo-inositol and other nutritional agents (Dong, 2016).
  4. Foetal Alcohol Spectrum Disorder (FASD) prevention, using nutritional supplementation, VIP related peptides, antioxidants and folic acid (Zhang, 2018).

Conclusions

I believe the role of environmental factors on birth defects might be underestimated, considering the proportion of cases without a known aetiology. The study of teratogens still relies primarily on the use of

in vivo

animal-based assays, which are limited in their capacity to mimic human development.

As reviewed, recent work has focused on simulating organ development with organoid cultures. The use of organoids for teratogen evaluation is not widely extended yet, but advances in simulating the development of the brain, heart, kidneys, and eyes indicate a wider use may not be far.

Advances in human embryo culture and eventually the development of artificial embryos will provide models that can more accurately resemble early

in-vivo

development. The goal is to have a prototype to create an assay that reliable, high-throughput and consistent.  However, human embryo models raise many ethical concerns.

I have tried to show that the study of certain environmental factors linked to birth defects has contributed to our current understanding of human embryonic development and the pathogenesis of congenital anomalies, while at the same time it has helped to improve the clinical diagnosis and prognosis of congenital diseases and the development of therapeutic strategies.

Nevertheless, research can reduce the global burden of birth defects even further by generating new preventive strategies against congenital infection, teratogens and other environmental factors, and potentially benefit millions worldwide.  No disease is so rare as to deserve none of our attention.

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Professional Philosophy And Occupational Therapy

The definition of occupational therapy as gradually metamorphosis from its genesis till date, yet it has gradually evolved from its first definition in 1914 by George Barton who stated that ‘if there is an occupational disease, why not an occupational therapy’. While in 1919, he further postulated that ‘occupational therapy is the science of instructing and encouraging the sick in such labours as will involve those energies and activities producing a beneficial therapeutic effect. Over the years, the definition of occupational therapy had transited and in 1923, Herbert J. Hall define occupational therapy as that which provide light work under medical; supervision for the benefit of patients convalescing in hospital and homes, using handicraft not with the aim of making craftsmen of the patients but for the purpose of developing physics and mental effectiveness. American occupational therapy Association (AOTA) proposed the definition that occupational therapy is the ‘art and science of directing man’s involvement in selected task to reinstate, reinforce and enhance performance, to facilitate learning of the skills and functions essential for adaptation and productivity, diminish or correct pathology and to promote and maintain health. In 1994 AOTA mmrevised the definition and stated that occupational therapy is the use of purposeful activity or interventions to promote health and achieve functional out come to develop, improve or restore the highest possible level of independence with person who is limited by a physical injury or illness.

The goal of occupational therapy is to assist the individual in achieving an independent, productive and satisfying life style. Occupational therapist use adaptive activities to increase the individual’s functioning and productivity in view of achieving independence and satisfaction.

Occupational therapy is a health discipline concerned with enabling function and well-being (Baum, 1997)

Occupation in Occupational Therapy

(Polatakjo 2007, Wilcock 2000), states that the ultimate impact of occupational therapy in multidisciplinary health care service must be a profound understanding of enabling occupation (Pollock and McColl 2003) also stresses that the knowledge of occupation is employed as a means to enhance the development of health in people. Occupational therapists also aspire to the goal of facilitating occupational engagement and performance as the end or outcome of therapy. Occupation is “the purposeful or meaningful activities in which human beings engage as part of their normal daily lives…… all aspects of daily living that contribute to health and fulfilment for an individual”(McColl 2003 p1)

Schwammle (1996) encourage occupational therapists to focus on enabling clients achieve a sense of well being via occupation.

In contrast, (Wilcock 2006) de-emphasises occupation in favour of established concepts that are more consistent with a medical model. He also stressed that medical focus, rather than an occupational focused may have resulted in therapists looking at remedying performance components rather than addressing occupation itself, but (Molineux, 2004) said it will be highly problematic as it will lead to issues of role blurring, role overlap and role ambiguity.

A different dimension to core philosophy of occupational therapy is functional independence or activity of daily living as the ultimate goal of occupational therapy (Thornton and Rennie 1998). Chavalier (1997) concurred that occupational therapists experience difficulty agreeing on what occupational therapy is, and also that the diverse opinion is a strength to the occupational therapy profession.

There seems to be an overall conclusion by occupational therapy experts that occupational therapy as a profession should mainly focus and emphasis on occupation as the core centre of the profession.

(Baum and Baptiste 2007, Law et al 2002, Wilcock 2000, Asmundsottir and Kaplan 2001) all stress that occupation should be central in occupational practices. Various authors also gave reasons why occupation should be the epicentre of occupational therapy:

It will provide an exclusive perspective that will ensure the professional survival of OT in health service (Pierce 2001)

It will unite OT and ensure its continued survival (Nelson 1996).

It will enable OT to achieve its full potential (Crabtree 2000)

Occupation-focused practice may result in more satisfying practice for individual occupational therapists (Molineux 2004, Wilding 2008)

Occupation focused may assist therapists’ intervention s to be more meaningful when dealing with complex issues (Persson et al 2001)

It makes OT to be a true, self-defining profession.

Metamorphosis Of Occupational Therapy

Right from the inception of occupational therapy. the concepts of occupation is the foundation upon which the profession is built. The founders of occupational therapy the likes of George Barton, Fleanor Clarke Slage, Adolph Meyer etc based the new profession on their own personal experiences of the health enhancing effects of engagement in purposeful and meaningful activities (Peloquin, 1991a), Kielhofner (1992) noted for the early part of twentieth century how occupation is seen to play an essential role in human life and lack of it could result in poor health and dysfunction, occupation is also seen as the link between the mind and soul. Occupational therapy

There was a shift of focus to mechanistic paradigm in the (1960s). These emphases the ability to perform depend on the integrity of body systems, and functional performance can be restored by improving or compensating for system limitations.

KIELHOFNER (1992) saw a growing dissatisfaction among occupational therapist with the mechanistic approach whiled Reilly (1992) called for therapist in the early 1960s to focus on occupational nature of humans and also the ability of the profession to emphasize on the occupation needs of people contemporary paradigm (1980- present day).(Molineux 2009)

Relationship between professional philosophy and occupational therapy

A professional philosophy helps set values, beliefs truths and focuses the therapist on the principles that governs his actions. It gives credence to the profession existence and substantiates reasons for practitioner’s therapeutics processes.

In studying the philosophical basis of a profession, it is essential to look at it from its three components as it relates to occupational therapy

Metaphysical component. This bothers on what the nature of humankind is. -active being, occupation performance, Reductive approach and Holistic approach.

Epistemology component. This relates to the development of a professional philosophy. It analyse the nature, origin and limits of human knowledge.(Adaptation, Thinking, feeling and doing)

Axiology component. It concerns with the values of the profession. Quality of life, client catered approach, code of ethics

Man is an active being whose development is influenced by the use of purposeful activities, using their capacity for intrinsic motivation; human beings are able to influence the physical and mental health and their physical environments through purposeful activity. Adaptation is a change in function that promotes survival and self-actualisation, it is also described as the satisfactory adjustment of individual s within their environment over time. . Dysfunction may occur when adaptation is impaired, while purposeful activity enhances the adaptive process.

Health care system has been developed from a reductionistic approach where man is viewed as separate body function and each part treated separately and focuses on specific problem for greater efficiency. However, medicine has metamorphosis into addressing all the bodily functions of the client, this is a holistic approach by occupational therapy traced to Adolf Meyer. He sees the human body as a live organism acting. The holistic approach emphasises organic and fundamental relationship between the parts and the whole being, an interaction of biological, psychological, socio-cultural and spiritual elements. Occupational therapy trend is shifting away from holistic practice to specialised (reductionistic) approach again. For example, occupational therapy practitioners working in hand rehabilitation refers to themselves as hand therapists or those in psychiatry call themselves psychiatric therapists.

Critical analysis of model and frame of reference

MODEL AND FOR

In advancing the theoretical foundation of occupational therapy, a model is defined as a theoretical simplification of a complex reality (Frolitch, 1993) and consists of several explicitly defined concepts. Conceptual models are schematic or graphic representation of concepts and assumptions that act as a guide for theory development.

The frame of reference is based on philosophy or a paradigm and attempts to describe or explain what we believe or value. Models are developed within a frame of reference. Hence, FOR are viewpoints, beliefs or values. FOR are connected sets of ideas that form the basis for action. (Duncan, 2006)

Reed and Sanderson (1999) states that no perfect or ideal model for health, functioning and disability exists for occupational therapists. Rather, they suggest that occupational therapists should select the aspects from those health models that most closely fit the belief and values of occupational therapy.

According to Townsend (2002), Occupational performance is defined as the result of the dynamic relationship between the person, the environment and the occupation. It refers to the ability to choose and satisfactorily perform meaningful occupations that are culturally defined and appropriate for looking after one’s self, enjoying life and contributing to the social and economic fabric in the community. Occupations are groups of activities and tasks of everyday life.

Activities of Daily Living (ADL)

The initial process of occupational therapy assessment involves interviews with the patient and the carer to establish previously held life roles and the tasks and activities that were completed within these roles. Observational assessment is undertaken of personal self-care tasks, including showering, dressing, toileting, grooming, and eating, and domestic or instrumental tasks, including meal preparation, shopping, cleaning, laundry, and management of finances and medications. Standardized measures may include the Functional Independence Measure (FIM), [6

MODELS

Model of human occupation (MOHO)

The model emphasis that occupational behaviour is a result of the human system, the

subsystem, the habitation subsystem and the environment.

MOHO is a behavioural model. He defines occupational performance from a behavioural perspective. The model sees occupational performance as a result of mind-brain-body performance subsystem.

Haglund and Kjellberg (1999) argue that the MOHO lacks the influence of the environment on human behaviour. Though it includes the environmental factor, he does not explain the interaction and relationship between the person and the environment.

Canadian Model of Occupational Performance (CMOP).

See in occupational performance terms of dynamic relation between occupation, environment and a person, the key elements of environment are cultural, institutional, physical and social. While the purpose of occupation can be leisure, productivity or self-care. The CMOP presents the person as an integrated whole, incorporates spiritual, affective, cognitive and physical need (Townsend, 2002) The CMOP defines occupational performance as the result of dynamic relationship between the person, the environment and the occupation.

OCCUPATIONAL PERFORMANCE MODEL (Australia)

In contrast to the ICF where ‘rest’ is a body function, ‘rest’ has an activity perspective in the OPM.

CORE PROCESS (HAGEDORN 2006)

The first extensive presentation of occupational therapy core competencies was produced by Mosey (1986) she based her domains of concern of the profession as performance components, occupational performances, the life cycle and the environment. While (Neistadt and Crepeau 1998) give a list at entry level to be development of skills, socialization in the expectation related to organisation, peers and the profession, acceptance of responsibility and accountability in relevant active-ties. In 1994,the college of occupational therapist published a position on ‘core skills and conceptual framework for practice’. Core skill is defined as the ‘expert knowledge at the hearth of the Professional’.

The unique core skills of occupational therapy are

Engage in purposeful activity and meaningful occupation as therapeutic tools to enhance health and wellbeing.

Enable people to explore, achieve and maintain balance in their daily living tasks.

Evaluate the effects of manipulate, physical and psycho-social environments, maximise function and social integration.

Ability to analyse, select and apply occupation to focused therapeutic media to enable dysfunction in daily living tasks and occupational roles.

For a therapist to be able to display core professionalism via the above listed core skills. The therapist needs to use four core processes.

Therapeutic Use of Self

In the heart of therapeutic intervention is the ability of the therapist to communicate with the client and establish a therapeutic relationship or alliance. Mosey (1986) described ‘conscience use of self’ as one of the legitimate tools of practice.

ASSESSMENT OF INDIVIDUAL POTENTIAL, ABILITY AND NEEDS

For an effective therapeutic intervention, there must be a clear and accurate evaluation of the potential and abilities of the clients in view of the client’s needs and goals. This is achieved through the array of tests, checklists and other assessment tools. Assessment may require detailed observation, measurement and repeated testing in relation to ADL which the individual engages.

OT is concerned with the whole spectrum of human skills through all ages: past, present and future. Possibilities and probabilities need careful evaluation which requires experience and indepth clinical reasoning.

ANALYSIS AND ADAPTATION OF OCCUPATION

A fundamental assumption of occupational therapy is that engagement in occupation promotes health and well being. Hence, occupational analysis seeks to break down the tasks into smallest units of which performance is composed. The client skill components can be identified and the therapist can map how this can be built into competence. To achieve this, the therapist must observe, record and analyse elements of performance via work, leisure and self care activities. The therapist also employs analytical methods to determine client interaction between occupational role and social life relationships.

ANALYSIS AND ADAPTATION OF ENVIRONMENT

Therapists acknowledge that the environment has an effect on behaviour. It facilitates interaction, reduce stress and promote engagement. Hence, adapting to the environment can enhance occupational performance or impede engagement in task. The analysis of the environment should be at an holistic level and not limited to the physical aspects alone, but also socio-cultural aspects, emotional and financier environment.

CODE OF ETHICS AND PROFESSIONAL CONDUCT COT 2010

On a daily basis, occupational therapists are confronted with situations that requires decisions. Moral and ethics have the potential to affect the clinician’s decision making practice. Ethics are philosophical stands on the rightness or appropriateness of various voluntary actions. The adoption of ethical principles is one characteristic often used to distinguish professions from other occupations (Vollmer & Mills, 1966).

The code of ethics and professional conduct produced by the college of occupational therapists (COT) and NPC are formulated to guide O. T in their professional conduct in terms of competent combination of knowledge, skills and behavior’s.

The code of ethics and professional conduct are sub – divided into major sections:

Service user welfare and autonomy, this includes: Duty of care, welfare, mental capacity and informed consent and confidentiality.

Service provision: Equality, Resourses, the occupational process, risk management and record keeping.

Personal professional integrity: Personal integrity relationships with service users, professional integrity, fitness to practice, substance misuse, personal profit or gain, and information representation.

Professional competence and lifelong learning: professional competence, delegation, collaborative working, combining professional development, and occupational therapy practice education.

Developing and using the profession’s evidence base.

The code of ethics and professional conduct enacted various laws upon which an occupational therapist base his/her practice, these include:

Health Act 1999 ‘Occupational therapist’ is protected by law and can only be used by persons who are registered with the health professions council (HPC)

O.T personnel must respect the right of all people under the Human Right Act 1998.

Mental Capacity Act 2005 code of practice states that: A person must be assumed to have capacity unless it is established otherwise.

Data protection Act 1998: gives individual the right to know what information is held about them and that personal information is handled properly.

Roles of COT and HPC (Code of ethics and professional conduct.COT,2010)

Arguements For and Against Obesity as a Disease

Obesity: Disease or Not

Over time there have been many debates on the topic of obesity, and whether it is classified as a disease or not. It has been very difficult to actually pinpoint the main reason for obesity occurring in people and the justification for what exactly causes a person to become obese. Obesity is a condition that has been sweeping over the world for many of years. Percentages including not only adults but children too have been increasing like never before.  Obesity is a disease that is connected to the improper nutrition that in a way the amount of fatty tissue in the body stored from  food taken starts to completely become unhealthy. Doctors talk about obesity when the BMI (body Mass Index)  is over 30 kilograms for every square meter. Obesity is most common when the total amount of food exceeds the total amount of exercises. Obesity is known as a diet-related chronic disease that requires many longtime medical treatments that help reduce the frequency of related  diseases and death rate.

Obesity does not leave any untouched organ in the person as it primarily affects the vessels in the body and therefore since all organs have vessels and they experience certain difficulties that depend on the amount of exceeding weight. As a result, most people that have obesity tend to suffer from either hypertension, high blood cholesterol and high blood pressure. People with obesity can also suffer from both types of diabetes. The dysfunction of the obesity-caused body organs may not be considered fatal at first, but altogether they create a strong base of the probability of a fatal outcome. The dysfunctions connected with the inability of obesity in patients are sometimes reproduce, plus there are all types of respiratory dysfunctions when the patients lungs do not manage with the tension of the body mass and the musculoskeletal depending on the given situation. Fatal illnesses that obese patients suffer from are sometimes faced with the following: cancer diseases, the gallbladder disease and others. It has shown in some results that because of this some obesity patients may die early from the different cardiovascular diseases.

For many years obesity has been a serious condition that has been generally discussed on whether it is a disease or not. Society has been facing obesity as a challenge as it has resulted in several diseases. Some people thought that if they classified obesity as a disease then their aim was to maximize both the researches and funding. This was to focus on obesity from a different medical and health approach. The National Heart, Lung, and Blood Institute had based their argument on which obesity is a complicated multifactorial chronic disease that is developed from multiple collective influences from countless factors. If people are not fully and properly informed and educated on obesity, then many people are at a higher risk of developing the condition. Obesity is a multifactorial condition that can be resulted from the environment, genetics, family history, behavior, habits and etc.

There have been case studies from the OMIM (Online Mendelian Inheritance in Man) databases and the PPI (Protein-Protein Interaction) network that have investigated the relationship between obesity and diseases. Both genes of obesity and the OMIM disease were gathered onto the network and the scores of their interactions were analyzed on the PPI gene pairs. The results of the experiments have concluded that diseases who are related to endocrine and nutrition are the top diseases related with obesity. Countless obesity-related disease associations were identified to confirm the relationship between obesity and the diseases. The results could help understand the mechanism of obesity and provide convenient insight of the prevention of the disease. This study also helps researchers emphasize the complicated characteristics on declaring obesity as a disease while also exposing a new course of research.

The World Obesity Federation had once argued in a position paper that other countries should recognize obesity as a disease. Their main reason being that obesity had fit the characteristic of a chronic, relapsing, progressive disease, and how it described the similarity on how diseases are caused by any agent that can or may adversely affect the host. There have been countries that agreed with what the World Obesity Federation was stating, like Portugal who had officially recognized obesity as a disease in 2004. As time went on many other organizations and countries started to recognize obesity as a disease including the Scottish Intercollegiate Guidelines Network in 2010, the American Medical Association in 2013, and the Canadian Medical Association in 2015. Although, there are still some people in Canada who still have to pay for obesity treatment because both the local and federal Canadian government do not officially recognize the standpoint on where the Canadian Medical Association is.

A common statement that many people assume about people who are obese is that it is a lifestyle choice that is caused by individual greed. Pushing the recognition of obesity that is sometimes caused by disease agents could help promote change to the way others perceive obesity and reverse the epidemic of obesity. Until obesity can be fully recognized as a chronic disease and not a lifestyle choice, it will unlikely decrease. People have been trying to get the government to help reduce obesity by influencing the build of the environment that could help promote physical activity as a population. There are also some institutions around the country that have been trying to push the government to invest in the reduction of obesogenic agents that would help decrease the so-called disease.

Scott Kahan, Director of the National Center of Weight and Wellness, also put in his opinion that many diseases are lifestyle related, but those who are classified as being obese are blamed and shamed unlike those who suffer from diabetes and heart disease. He states that obese people are not eating worse or moving less than those who are considered healthy  and while normal people who carry some type of chronic disease, diabetes, or hypertension are being supported or cared for, even though lack of physical activity or an unhealthy diet were probably the cause of developing the disease in the first place, obese people are made a joke. With such prejudice that gets in the way when discussing the topic of obesity, it can prevent fully understanding and finding a way to actually treat the disease. Also with many health researchers and physicians supporting his statement expressing themselves that entertaining obesity as a personal failing is not only getting nowhere but as medically inaccurate.

Many organizations claimed that labeling obesity as a disease it is supposed to help doctors and medical researchers find a plan that will help manage the growing obesity problem throughout the world. The most common answer people have suggested to decrease the problem with obesity would be to eat less, but there are much more complicated factors that can make it hard for a person to change their behavior. Medical researchers have expressed that across the country there are many food and fast food industries that are intertwined with the United States broken government and also how Congress does not have this country’s best interest in its’ citizen’s health. Even with their declaration about Congress, organizations do give credit to the programs that have been introduced to help the problem, like the WIC ( women, infant, and children) program, that provide strict guidelines that only allow certain healthy foods from specific lists.

A member of the association’s board, Dr. Patrice Harris, had commented on how recognizing

obesity

as a disease could help change the way many medical communities tackle the complex issue that has affected roughly about one third of Americans in the United States.  This change would fight against many obesity-related diseases, such as type 2 diabetes and heart disease. It would also help improve fundings for all obesity drugs, counseling and surgery. Although, the Council of Science and Public Health had claimed that obesity should not be identified as a disease because the Body Mass Index (BMI) measurement is not considered to be completely accurate, given that it does not measure a person’s overall content of fat or muscle tissue. The council had continued to prove their argument by expressing the given limitations of BMI to diagnose obesity in a clinical practice and how it is unpredictable that recognizing obesity as a disease, rather than a disorder or condition, will result in improved health outcomes.

Even with the council’s claim that obesity was not to be classified as a disease, they still had to agree that obesity did fit some parts of the medical disease criteria, like the different impairing body function. Even with their shared agreement on the previous statement there are still those who will just not accept the consideration of obesity being categorized as a disease. Many people did not agree with this change in classification in claiming obesity a disease, which had been later stated that it would classify approximately 78 million adults and 12 million children of Americans in the United States as sick and would lead to more medical attention that could be expensive, instead of improving one’s lifestyle changes. The resolution that the council had came to was that obesity is not a disease but instead a consequence of an individual’s lifestyle built by overeating and inactivity. The council also tried to support their conclusion by comparing obesity being the same as

lung cancer

in which it was developed because of the person’s choice to smoke cigarettes.

Those who have disagreed with obesity being a disease say that it is less a matter of a person’s weight rather than their body fat. Like a person with a high BMI may be very fit, and a person with a low BMI can be in a very unhealthy shape. They used examples like college or professional football players who qualify as being obese, but have a very low percentage of body fat. Also according to the BMI measurement, Dwayne Johnson is also classified as obese. To them a person with a small frame may have more body fat but a normal BMI and vice-versa. There are people who are not harmed by having extra weight on them and sometimes they actually benefit from it. Examples like these are reasons to why some medical researchers think twice before considering obesity a disease and labeling people who are obese diseased.

The council announced that the relationship between morality and being overweight is complicated and people are far from understanding the countless ways in which the weight and health of someone is connected. Additionally, if they were to incorrectly categorize the people who can control their way of life by simply increasing their physical activities or change their diet as being sick and in need of medical assistance it could lead to many drug treatments and unnecessary surgery that could result in many complications and side effects for the individual. By informing the individuals who are considered to be obese that they carry a disease could decrease their sense of control over their ability to make the changes that need to be made in order to get them back into a healthy behaviorism. Council had went along the lines on which it could be very self-defeating to someone who is told that they have a disease that is out of their control. They believe that there is little evidence in which identifying obesity as a disease will cause it to become achievable in reducing the problem.

The individuals who side with the council have stated that political and economic changes should be made in order to reduce the obesity problem and stop performing unnecessary surgeries for those who are not able to pay for it. Increasing the availability of good quality foods that are affordable for everyone and safe neighborhoods that provide all types of physical opportunities for people of all ages would be more effective than having people seek medical attention for being obese. The workplace could also help provide encouragement of the health and fitness of their employees which would make it easier for them to choose a more healthy decision. With easy and reasonable solutions like the ones mentioned before, council believes that it does not take the recognition of obesity as being a disease to change the way it could prevent the issue. It does not only spare the price of having to pay hundreds or sometimes thousands on medical treatment, but also helps guide the individual away from entering a path so drastic.

Discussing the expense of medical treatments for obesity would be expensive to not only the patient but to the nation itself. Obesity has added 9.1% to the United States health funds and accounts for $222 billion of both Medicaid and private health insurance spendings. Depending on the transformation from overweight to minimal obesity or from minimal obesity to second-rate obesity, the expenses from trying to find effective medical treatments for the issue would increase the annual cost from around $13 per year for every male and $45 per year for every female. But by providing easy and basic lifestyle treatments for obesity it could help reduce the annual expense by saving $90 for every male and $300 for every female per year. By categorizing obesity as a disease it would only increase the nation’s spending on trying to provide different medical remedies and surgeries that would not only be unnecessary but also leave the country further into debt.

Also by trying to perceive obesity as a disease based only on an individual’s BMI would make no sense medical wise because physicians need to examine the patient’s history, cholesterol, blood insulin, and etc. Decisions need to be based on the individual’s complete profile not on an unpredictable variable. The most common cause of obesity are the dysfunctions in the patient’s body. Medicine is always an option for the treatment of obesity and the most beneficial type of therapy is lifestyle medicine. Cultural medicine when being compared to clinical medicine is the best type of treatment when discussing the topic on obesity. The surroundings in which individuals populate could also be a cause in how obesity has went from being a rare subject to a universal concern through the decades. Fundamental changes around the environment will provide better opportunities for people to use their feet and forks and not having to rely on pharmacological treatments.

While reviewing the perspectives of the two-sided discussion there is really no way to determine if obesity is truly considered to be a disease or not, considering how both sides provide factual and valid reasons for their conclusions. The issue on obesity will continue to be explored around the globe as the years continue, no matter how much medical information the health community has retained. Not knowing if obesity will eventually be classified as a disease or simply a negative lifestyle choice it is a matter that should neither be avoided or ignored but faced head-on. The nation’s consideration towards every individual who is to be considered obese needs to continue to improve and advance until the problem at hand is at its lowest it has ever been.


Works Cited

  • Ata, Rheanna N., et al. “Obesity as a Disease: Effects on Weight-Biased Attitudes and Beliefs.”

    Stigma and Health

    , vol. 3, no. 4, Nov. 2018, pp. 406–416.
  • Braveman, Paula.

    A Health Disparities Perspective on Obesity Research

    . 2009.
  • Eileen Beal. “AJN REPORTS: The Pros and Cons of Designating Obesity as a Disease.”

    The American Journal of Nursing

    , vol. 113, no. 11, 2013, p. 18.
  • Fitzgerald, Kelly. “Obesity Is Now A Disease, American Medical Association Decides.”

    Medical News Today

    . MediLexicon, Intl., 17 Aug. 2013.
  • Lei Chen, et al. “Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective.”

    Genes

    , vol. 8, no. 12, Dec. 2017, p. 392.
  • Nutter, Sarah, et al. “Framing Obesity a Disease: Indirect Effects of Affect and      Controllability Beliefs on Weight Bias.”

    INTERNATIONAL JOURNAL OF OBESITY

    , vol. 42, no. 10, pp. 1804–1811.

Psoriasis Case Study


Case Study


B. Trimble


Case Study

P.D. a twenty-three-year-old female presents with symptoms of psoriasis. She has several thick scaly, well defined, erythematous plaques, which are silvery in color. The patient reports that she has just returned from a twelve-day trip to southern Louisiana to work the ecosystem as part of her education as an environmental engineer. During the trip, she had significant solar exposure, although she wore sunscreen. The expanded and prominent plaques cover her elbows and thighs, and there is a patch on her scalp. Her lesions cover about fifteen percent of her body. She occasionally applies moisturizing lotion or witch hazel if it becomes too irritating. All other body systems are normal.

Patient states “I have always had some rashes, although usually not this bad.”


Past Medical History

“Some rashes

,”

otherwise non-contributory


Social History

Recent trip to southern Louisiana for ecosystem work related to studies as an environmental engineer.


Physical Examination

Several thick scaly, well define, erythematous plagues, silver in color.

Expanded plague and prominent plagues cover elbows and thighs, with an area on the scalp. Plague coverage is fifteen percent of the body.

Significant sun exposure

All other body systems are within normal limits.

Reviewing the symptoms, the primary diagnosis is plague psoriasis. Psoriasis is a chronic inflammatory disease of the skin in which the production of epidermal cells occurs at a rate that is faster than normal. The cells in the basal layer of the skin divide too quickly, and the newly formed cells move rapidly to the skin surface and become evident as profuse scales or plagues of epidermal tissue. The psoriatic epidermal cell may travel from the basal cell layer to the stratum corneum and be cast off in three to four days, which is in sharp contrast to the normal twenty-six to twenty-eight days. As a result of the increased number of basal cells and rapid cell passage, the normal events of cell maturation and growth cannot take place. This abnormal process does not allow the formation of the protective layers of the skin (PubMed Health, 2012).

Psoriasis, one of the most common skin diseases, affects approximately two percent of the population. There appears to be a hereditary defect that causes overpopulation of keratin. The primary defect is unknown. A combination of specific genetic makeup and environmental stimuli may trigger the onset of the disease. There is evidence that the cell proliferation is mediated by the immune system. Periods of emotional stress and anxiety aggravate the condition, and trauma, infections, and seasonal and hormonal changes are trigger factors. The onset may occur at any age, but is most common between the ages of ten and thirty-five years. Psoriasis has a tendency to improve and then recur throughout life (PubMed Health, 2012).


The clinical manifestation

The lesions appear as red, raised patches of skin covered with silvery scales. The scaly patches are formed by the buildup of living and dead skin that results from the vast increase in the rate of skin-cell growth and turnover. If the scales are scraped away, the dark red base of the lesion is exposed, producing multiple bleeding points. These patches are not moist and may or may not itch. The lesions may remain small, giving rise to the term “guttate psoriasis.” Usually, the lesions enlarge slowly, but after many months they coalesce, forming extensive irregular shaped patches (PubMed Health, 2012). Psoriasis may range from a cosmetic source of annoyance to a physically disabling and disfiguring affliction. Particular sites of the body tend to be affected by this ailment; they include the scalp, the area over the elbows and knees, the lower part of the back, and the genitalia. Psoriasis also appears on the extensor surfaces of the arms and legs, on the scalp and ears, and over the sacrum and intergluteal fold. Bilateral symmetry is a feature of Psoriasis (Brunton, Chabner, & Knollman, 2011). The disease may be associated with arthritis of multiple joints, causing crippling disability. The relationship between arthritis and psoriasis is not understood. Another complication is an exfoliative psoritic state in which the disease progresses to involve the total body surface (Brunton, Chabner, & Knollman, 2011).


Management

The goals of management are to reduce the rapid turnover of the epidermis and to promote resolution of the psoriatic lesions. Thus, the goal is limited to control of the problem, because there is no cure (Brunton, Chabner, & Knollman, 2011).

The therapeutic approach should be one that the patient understands; it should be cosmetically acceptable and not too disruptive of life-style. It will involve a commitment of time and effort by the patient.

First, any precipitating or aggravating factors are removed. Then as assessment is made of life-style, since psoriasis is significantly affected by stress. The patient must also be advised that treatment of severe psoriasis can be time-consuming, expensive, and esthetically unappealing at times. Treatment will begin with Vectical ointment (calcitriol) 3mcg/g, topical use only. Apply twice daily, once in the morning and once in the evening, the maximum weekly dose should not exceed 200 gram (National Institute of Health, 2012). Treatment will extend to eight weeks, with follow up in office at that time. Each gram contains 3 micrograms of calcitriol. Vectical should not be applied to the face, eyes, or lips. It should be used with caution in patients receiving medications known to increase calcium serum levels, such as calcium supplements, vitamin D supplements, and thiazide diuretics. Vectical may cause sunburn more easily, avoid the sun, sunlamps, or tanning beds while using Vectical ointment. Use a sunscreen or wear protective clothing when having to be outside for more than a short time (National Institute of Health, 2012).

Vectical ointment is indicated for the topical treatment of mild to moderate plague psoriasis in adults eighteen years and older. Calcitriol (Vectical) contains 1,25-dihydroxycholecalciferol, the hormone active form of vitamin D3. Calcitriol 3-mcg/g ointment is similar in efficacy to calcipotriene 0.005-% ointment for the treatment of plague type psoriasis on the body and is better tolerated in intertriginous and sensitive areas of the skin (Katzung, Mastes, & Trevor, 2012). Vectical contains calcitriol, which studies have shown to be fetotoxic, and should be used in pregnancy only if the potential benefits justify the potential risk to the fetus. It is not known if calcitriol is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Vectical ointment is used by nursing women. If the patient thinks she may be pregnant, they will need to discuss the benefits and risks of using Vectical ointment while pregnant (Katzung, Mastes, & Trevor, 2012).


Patient Education


Use only as directed, for external use only. Vectical is to be applied only to areas of skin affected by psoriasis.

Vectical should be gently rubbed into the skin so that no medication remains visible. As you may sunburn more easily, avoid the sun, sunlamps, or suntan beds/booths while using Vectical ointment. Use a sunscreen with an SPF of 30 or greater; wear protective clothing when you must be outside for more than a short time (Brunton, Chabner, & Knollman, 2011).

All medications may cause side effects, but many have no, or minor, side effects. Minor skin discomfort at the application site is the most common side effect of Vectical ointment. Notify the medical provider if these side effects occur; rash, hives, itching, difficulty breathing, chest tightness, swelling of the face, mouth or lips, new or worsening skin irritation ( blistering, flushing, burning, severe discomfort, or redness), symptoms of hypercalcemia (weakness, nausea, confusion, constipation, excessive thirst, fast, slow or irregular heartbeat) (National Institute of Health, 2012).


Treatment Plan

Vectical (calcitriol) 3mcg/g, 100 G tube; twice daily.

Follow up appointment in eight weeks.

Laboratory testing to include calcium serum levels and hCG testing now and at followup visit. Additional laboratory testing to include skin biopsy for fungal infection. Patient education on use and precautions of medications, and supplements

.

Referral to psoriasis support group for emotional support and education.


Differential Diagnosis

Review of symptoms and history of working in the environment leads to questioning if the patient presentation is a case of Tine Corporis and Tina Capitis. As the patient was in an environmental area that is subject to large fungal growth and exposure to a wet climate increases the risks for fungal infestation, this is the differential diagnosis (Brunton, Chabner, & Knollman, 2011).

Tina capitis is a contagious fungal infection of the hair shafts. Microsporum and Trichophyton species are dermatophytes that infect hair. Clinically, one or several round patches of redness and scaling are present. Tinea Corporis or Tina circinata begins as an erythematous macule advancing to rings of vesicles with central clearing. The lesions appear in clusters, usually on exposed areas of the body. These may extend to the scalp, hair, or nails. As a rule, there is an elevated border consisting of small papules or vesicles. Coalescence of individual rings may result in large patches with bizarre scalloped borders. Use of a woods lamp will help in the diagnosis. The fungal infection will glow under the light. Skin biopsy will confirm the presence of fungal infestation (Katzung, Mastes, & Trevor, 2012).


References

Brunton, L., Chabner, B., & Knollman, B. (2011).

Goodman & Gilman’s: The pharmacological basis of therapeutics

(12 ed.). McGraw-Hill.

Katzung, B., Mastes, S., & Trevor, A. (2012).

Basic & Clinical Pharmacology

(12 ed.). McGraw-Hill.

National Institute of Health. (2012, January).

Vectical ointment

. Retrieved from U.S. National Library of Medicine:

http://www.dailymed.nlm.nih.gov/dailymed/druginfo.cfm

PubMed Health. (2012, November).

Psoriasis

. Retrieved from PubMed Health:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001470

Effects of Sunlight on DNA and the Immune System



Sunlight: Friend or Foe?

(With reference to the effects of sunlight upon DNA and the immune system discuss the involvement of sunlight in disease.)

  • Is sunlight harmful or beneficial to health?

Most of the positive effects of sunlight are due to the UVB induced production of vitamin D in the skin which acts in aiding the immune system in several different ways that I will discuss later on in this assignment. Some other positive effects include increased UVR resistance of skin after prolonged sunlight exposure, and the uses of phototherapy to treat several skin diseases. There are some negative effects of sunlight that I will go into more detail on, such as sunburn increasing the risk of malignant melanoma by twofold, and the rare disease vitamin D toxification, which can be extremely harmful to health.




Evidence for sunlight aiding in disease prevention:

  • Vitamin D deficiency and how vitamin D is derived from cholesterol as a result of exposure to UVB light.

In this modern era, it may seem as though vitamin D is easily accessible to people through sunlight, or through our dietary intake, however, vitamin D deficiency is very common. Vitamin D deficiency is defined as circulating 25D levels of less than 20ng/ml (Bischoff-Ferrari et al. 2006) and a vitamin D sufficient individual is defined as having circulating 25D levels greater than 30ng/ml. There are especially high levels of vitamin D deficiency in European and North American populations

, (Holick, M. F. 2006)

shown by a survey of healthy females across Northern Europe, showing that there was widespread vitamin D insufficiency, (Andersen, R. 2005) and another study which found that 42% of African-American women in the US had circulating 25D concentrations of less than 15ng/ml. (White, J. 2019) This trend could be explained by the fact that vitamin D synthesis is strongly influenced by skin colour. Atmospheric ozone absorbs solar UVB irradiation, meaning that the surface intensity of UVB varies with latitude and the time of year. In temperate regions, vitamin D

3

synthesis doesn’t take place during the winter months as surface solar UVB irradiation levels aren’t high enough to induce vitamin D

3

synthesis. (Holick, M. F. 2006). These factors, as well as inadequate vitamin D intake in most people’s diets, means that vitamin D insufficiency increases with increasing latitude. (Holick, M. F. 2007).


Fig.1, formation of vitamin D



3.


Vitamin D is derived from the steroid 7-dehydrocholesterol, which is derived from cholesterol, and stored in the sebaceous glands of the skin. 7-dehydrocholesterol will absorb UVB light (~280-315nm) when exposed to sunlight and form previtamin D



3



, which is isomerised into vitamin D



3



by thermal conversion.( figure 1)


(

3)

Humans obtain most of their vitamin D through the action of sunlight on their skin, with the photolytic conversion of 7-dehydrocholesterol to vitamin D in the skin. This vitamin D then undergoes other metabolic conversions, such as the enzyme cytochrome P450,CYP2R1 catalysing 25-hydroxylation to form 25OHD in the liver, which is the main circulating form of vitamin D. (1)[11]. Then, in the proximal convoluted tubules of the kidney, 25OHD-1ahydroxylase converts the 25OHD to 1,25-dihydroxyvitamin D (2,25(OH)2D). this compound acts as a hormone to regulate mineral homeostasis and bone metabolism. (1)[12].

  • How vitamin D can aid in innate antibacterial immunity (using TB as an example).

Connections between infectious disease and vitamin D deficiency were recognised in the 19

th

century when it was discovered that patients suffering from tuberculosis (TB) were greatly benefitted by solar radiation.(5)[22]. Around 20 years ago, associations between vitamin D deficiency and TB susceptibility were discovered, and how 1,25D suppresses the proliferation of

Mycobacterium tuberculosis

in human macrophages. (5). It has been shown in a recent study of a genetically homogeneous immigration population of Gujarati Asians in London with high TB rates that there was an association between 25D deficiency and active disease.(5)[101].

Studies have shown that increasing the serum levels of 25OHD, lead to enhanced bacterial killing, leading to a proposition that variations in vitamin D status could enhance or impair monocyte innate immune responses to infections.(1)[45]. The potential positive effects of vitamin D against TB infection are not the only benefit of the ‘sunshine vitamin’, as vitamin D may also be helpful in fighting other bacterial or viral infectious agents. For example, one small study found that elderly women undergoing long-term osteoporosis treatment with vitamin D had a significantly lower rate of

Helicobacter pylori

infections than women in an untreated control group. (5)[44]. Scientists such as Cannell have argued that cutaneous vitamin D production provides the “seasonal stimulus” associated with solar radiation that causes the seasonality of influenza epidemics.(5)

  • How dendritic cells express vitamin D receptors and are a likely target for vitamin D-mediated immunoregulation.

The VDR is a nuclear receptor and ligand-activated transcription factor made of a highly conserved DNA binding domain and an α-helical ligand binding domain (5)[72]. It has been recognised that dendritic cells express vitamin D receptors (VDR), showing that they are a likely target for vitamin-D regulated immunoregulation. (1)[64]. The VDR is present in most immune cells, such as T lymphocytes, neutrophils as well as dendritic cells.(5)[3]. A mechanism is present whereby VDR-rich immature dendritic cells respond to 1,25(OH)2D produced by VDR-depleted mature dendritic cells. It inhibits some dendritic cells from maturing, allowing activation of normal immune responses, while preventing exaggeration of this response and the possible negative effects. Therefore it is seen that vitamin D acts as a modulator of dendritic cell function, and therefore the function of the immune system.(1). 1,25D acts directly on T lymphocytes to inhibit T-cell proliferation (5)[92] , and represses the transcription of genes coding for important T helper 1 (Th1) cytokines, eg: gamma interferon and interleukin-2. 1,25D therefore acts as a suppressor of antigen presentation and Th1 activation, which supresses Th1-driven autoimmune responses by polarizing T-helper responses towards a more regulatory Th2 phenotype. (5). Impaired vitamin D signalling (caused by VDR polymorphisms) and/or environmental factors (insufficient sunlight exposure) may contribute to the onset and progression of autoimmunity. (3).

  • How studies have shown the ability of 25OHD to stimulate antibacterial activity in monocytes, with reference to Niels Finsen’s (1903) demonstration of curing Lupus Vulgaris with exposure to light.

The earliest record of a link between sun exposure and skin disease is from the ancient Egyptians 5000 years ago. Modern medical light therapy for skin diseases started in 1877 when it was reported that exposure to light inhibited fungal growth in test tubes (Downs and Blunt).(6). In 1903, Niels Finsen received the Nobel Prize for Medicine after demonstrating that he could cure Lupus Vularis with light exposure from an electric arc lamp. Cod liver oil (a rich source of dietary vitamin D) was also used as a treatment for TB.(1)[72].

From the late 1800s, phototherapy became key to TB treatment regimes, as prolonged exposure to sunlight can kill the bacteria that cause the TB. Infected children were often encouraged to spend more time outdoors, as they had often come from dark and polluted city slums, so exposing their skin to sunlight raised their vitamin D levels, helping their immune system to fight the bacteria. Due to the nature of sunlight (namely it not being available at all times), artificial alternatives were developed such as the Finsen lamp, which used UV rays to target the worst affected areas of a patient in all seasons. (7).

  • How supplementation with vitamin D has reported to protect against type 1 diabetes as an autoimmune disease.

Vitamin D deficiency has been linked to an increased risk or severity of autoimmune diseases such as type 1 diabetes. (1) [134]. And supplementation with vitamin D has been shown to protects against this. (1)[136]. Under dietary vitamin D restriction, the NOD mouse (a type 1 diabetes model) has shown increased disease severity (1) [137]. Certain VDR gene haplotypes appear to protect against diabetes, and polymorphisms in the CYP27B1 gene have been seen to affect a person’s diabetes susceptibility (1) [139].




Evidence for sunlight causing disease:


  • How CPDs produced by UV light cause mutations in sunlight-induced melanomas.


Fig.2, formation of CPDs after UVR exposure


Formation of T5mC dimeric photoproducts. CPD, cyclobutane pyrimidine dimers, pyrimidine (6-4) pyrimidone photoproducts, sugars are represented by triangles, phosphate groups by a circle.


(10)

Cyclobutene pyrimidine dimers (CPDs), are DNA photoproducts created after a UV photon is absorbed by thymine or cytosine. These CPDs can cause sunlight induced melanoma mutations . In melanocytes, CPDs can be generated for more than 3 hours after UVA exposure from sunlight or tanning beds. UVB is also known to induce DNA damage through creation of CPDs. (4)[20] Oxidative damage by creation of free radicals, such as singlet oxygen and hydrogen peroxide, occurs at all ultra violet radiation frequencies. Cytosine containing CPDs initiate UV-signature C to T mutations in DNA. ‘Dark CPDs’ occur when UV-induced nitrogen and oxygen species combine to excite an electron in melanin (a skin pigment) fragments. This means that melanin may be both carcinogenic and protective against cancer. (2)

  • How sunburns are associated with a doubling of the risk of melanoma due to UVB inducing DNA damage by creation of CPDs and creation of free radicals

The causes of melanoma are unknown, but there are believed to be links with genetic factors. The main non-genetic cause is exposure ultra violet radiation. Sunburns are associated with increasing the risk of melanoma by twofold, whereas non-burning UV exposure is associated with a reduced risk of melanoma. (4)[12]. Studies have found that outdoor workers have a lower incidence of melanoma than indoor workers. (4)[13]. With respect to sunburns, melanocytes are not replicating cells, so once DNA damage has occurred cellular replication need to occur because of the possibility of unrepaired or mis-repaired melanocytes to develop into malignant melanoma.(4)[20]. It is thought that chronic non-burning sun exposure protects against sunburn and melanoma development due to increased melanisation and epidermal thickening, or from higher vitamin D levels. (4)[25].

  • Vitamin D Toxicity

Although not directly caused by sunlight, vitamin D toxicity (VDT) and its clinical manifestation, severe hypercalcemia, are caused by excessive long-term intake of vitamin D, existence of a disease that produces the active vitamin D metabolite, or a defect of the vitamin D metabolic pathway. The most common symptoms include confusion, recurrent vomiting, abdominal pain, and dehydration. VDT is rare but can have serious health effects is it is not identified quickly. (9)

  • Conclusion

My research has shown the effects of vitamin D (obtained through the action of sunlight on the skin) on both innate and adaptive immune responses, and supports the hypothesis that vitamin D may be able to prevent proliferation of pathogens like

M.tuberculosis

, while helping to prevent autoimmune diseases by supressing the damaging effects of prolonged inflammation. Studies have shown a clear link between vitamin D deficiency and several common immune health problems, however, the innate antibacterial activity of vitamin D seems to be restricted to primates which express the VDR, which poses the question of how valid the studies conducted on mice are in relation to the VDR. I have also described the negative effects of sunlight, such as the production of CPDs through UVR exposure, which leads to the formation of malignant melanomas in some cases. I also touched on the positive effects of prolonged non-burning sun exposure such as increased resistance to sunburn and melanoma development. Overall, it can be seen that there are many health benefits of prolonged sunlight exposure, and no real health risks of sunlight as long as no sunburn occurs.



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